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Reviews of Environmental Contamination and Toxicology Volume 208 pp 111–160Cite as

Isomer Profiling of Perfluorinated Substances as a Tool for Source Tracking: A Review of Early Findings and Future Applications

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Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 208))

Abstract

The ubiquitous detection of perfluorinated acids (PFAs) and their precursors (PFA precursors) in the global environment has led to concern over their effects in humans and wildlife. This is exacerbated by evidence of developmental toxicity (Lau et al. 2007; Apelberg et al. 2007; Fei et al. 2008), along with persistence, chain length-dependent bioaccumulation potential (Houde et al. 2006), and long-range transport potential (Wallington et al. 2006; Wania 2007; Armitage et al. 2006, 2009a, b). In the over half-century of global perfluorochemical manufacturing, the two most commonly used synthetic methods have produced products with very different isomeric purities. Despite the fact that both branched and linear PFA and PFA-precursor isomers exist in the environment, quantitative analysis of these chemicals is, for the most part, still conducted by eluting all isomers together and integrating them as a single peak. This practice has continued despite the fact that emerging literature suggests that more accurate and informative data can be generated by isomer-specific analysis.

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Acknowledgments

The 3 M Co. is thanked for providing a generous donation of ECF FOSA, PFOS, and PFOA. Funding for NSERC VF (ADS) was provided by Chemicals Management Plan, Science and Risk Assessment Directorate to Derek Muir, EC Burlington. Funding for materials, supplies, and instrument time was provided through an NSERC Discovery Grant, an Alberta Ingenuity New Faculty Grant (JWM), and an Alberta Ingenuity graduate student scholarship (JPB). Alberta Health and Wellness is thanked for support of laboratory activities.

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  1. Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2G3, Canada

    Jonathan P. Benskin & Jonathan W. Martin

  2. Environment Canada, Water Science and Technology Directorate, Burlington, ON, L7R 4A6, Canada

    Amila O. De Silva

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  1. Jonathan P. Benskin
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  2. Amila O. De Silva
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  3. Jonathan W. Martin
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Correspondence to Jonathan W. Martin .

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    Pim De Voogt

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Benskin, J.P., De Silva, A.O., Martin, J.W. (2010). Isomer Profiling of Perfluorinated Substances as a Tool for Source Tracking: A Review of Early Findings and Future Applications. In: De Voogt, P. (eds) Reviews of Environmental Contamination and Toxicology Volume 208. Reviews of Environmental Contamination and Toxicology, vol 208. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6880-7_2

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