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Sperm Chromatin Structure Assay (SCSA®): 30 Years of Experience with the SCSA®

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Sperm Chromatin

Abstract

The SCSA® is one of the most widely utilized tests of sperm DNA damage. There are now a number of commercial kits available for testing of sperm DNA fragmentation in which great variations of clinical thresholds exist both within the same test and between tests. This presents a real problem for the clinics in providing a correct diagnosis and prognosis to patients. The greatest utility of the SCSA® has been to suggest when the %DFI is >25% to do changes in lifestyle and/or medical intervention to reduce this value. In addition, such couples should avoid spending time in unsuccessful IUI treatment but instead move on to IVF and preferably ICSI for the greatest success.

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Author information

Authors and Affiliations

  1. SCSA Diagnostics, 107, 219 Kasan Ave, Volga, SD, 57071, USA

    Donald P. Evenson PhD, HCLD

  2. Emeritus, South Dakota State University, Brookings, SD, USA

    Donald P. Evenson PhD, HCLD

  3. Department of Obstetrics and Gynecology, Sanford Medical School, University of South Dakota, Sioux Falls, SD, USA

    Donald P. Evenson PhD, HCLD

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  1. Donald P. Evenson PhD, HCLD
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Correspondence to Donald P. Evenson PhD, HCLD .

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Editors and Affiliations

  1. St. Mary's Hospital, Div. Urology, McGill University, Lacombe Avenue 3830, Montreal, H3T 1M5, Québec, Canada

    Armand Zini

  2. Lerner College of Medicine, Center for Reproductive Medicine, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Evenson, D.P. (2011). Sperm Chromatin Structure Assay (SCSA®): 30 Years of Experience with the SCSA® . In: Zini, A., Agarwal, A. (eds) Sperm Chromatin. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6857-9_9

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  • DOI: https://doi.org/10.1007/978-1-4419-6857-9_9

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  • Online ISBN: 978-1-4419-6857-9

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