Sperm Chromatin Structure Assay (SCSA®): 30 Years of Experience with the SCSA®



The SCSA® is one of the most widely utilized tests of sperm DNA damage. There are now a number of commercial kits available for testing of sperm DNA fragmentation in which great variations of clinical thresholds exist both within the same test and between tests. This presents a real problem for the clinics in providing a correct diagnosis and prognosis to patients. The greatest utility of the SCSA® has been to suggest when the %DFI is >25% to do changes in lifestyle and/or medical intervention to reduce this value. In addition, such couples should avoid spending time in unsuccessful IUI treatment but instead move on to IVF and preferably ICSI for the greatest success.


Sperm chromatin structure assay Sperm DNA damage 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.SCSA DiagnosticsVolgaUSA
  2. 2.EmeritusSouth Dakota State UniversityBrookingsUSA
  3. 3.Department of Obstetrics and Gynecology, Sanford Medical SchoolUniversity of South DakotaSioux FallsUSA

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