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The Genetic Bases of Asthma

  • Carlo Selmi
  • Maria De Santis
  • M. Eric Gershwin
Chapter

Abstract

Asthma is characterized by acute clinical symptoms such as bronchoconstriction, bronchial inflammation and cough due to increased smooth muscle contractility, epithelial secretion, and tissue remodeling ultimately leading to airway thickening. Numerous genetic, environmental, and hormonal factors underlie the pathological antigen–antibody reaction inducing a vago-vagal axon reflex. The biochemical mechanisms involved in asthma exacerbations include a disequilibrium between two opposite second messenger systems in the airways, favoring the PLC–PKC over the cAMP cascade.

Keywords

Atopic Dermatitis Allergic Rhinitis Airway Smooth Muscle Cell Candidate Gene Association Study Asthma Susceptibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Carlo Selmi
    • 1
    • 2
  • Maria De Santis
    • 3
  • M. Eric Gershwin
    • 1
  1. 1.Division of Rheumatology, Allergy and Clinical Immunology, Department of Internal MedicineUniversity of California at DavisDavisUSA
  2. 2.Autoimmunity and Metabolism Unit, Department of MedicineIRCCS Istituto Clinico HumanitasMilanItaly
  3. 3.Clinica Medica, Studio Medici ESTIRCCS Istituto Clinico HumanitasMilanItaly

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