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Familial Colorectal Cancer Type X

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Abstract

Three to four percent of colon cancers occur in the setting of inherited or familial cancer syndrome. Currently approximately half of these are currently attributed to hereditary nonpolyposis colorectal cancer (HNPCC) [1, 2].

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References

  1. Brand, R.M., et al. Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: influence of smoking. World J Gastroenterol 2006. 12(28):4485–91.

    PubMed  Google Scholar 

  2. Boland, C.R. Decoding hereditary colorectal cancer. N Engl J Med 2006. 354(26):2815–7.

    Article  PubMed  CAS  Google Scholar 

  3. Lynch, H.T., Lynch, P.M., Albano, W.A., Lynch, J.F. The cancer family syndrome: a status report. Dis Colon Rectum 1981. 24:311–22.

    Article  PubMed  CAS  Google Scholar 

  4. Lynch, H.T., et al. Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies. Cancer 1985. 56:939–51.

    Article  PubMed  CAS  Google Scholar 

  5. Muir, G.G., Bell, A.Y., Barlow, K.A. Multiple primary carcinomata of the colon, duodenum, and larynx associated with keratoacanthomata of the face. Br J Surg 1967. 54:191–5.

    Article  PubMed  CAS  Google Scholar 

  6. Torre, D. Multiple sebaceous tumors. Arch Derm 1968. 98:549–51.

    Article  PubMed  CAS  Google Scholar 

  7. Jass, J.R. Hereditary non-polyposis colorectal cancer: the rise and fall of a confusing term. World J Gastroenterol 2006. 12(31):4943–50.

    PubMed  CAS  Google Scholar 

  8. Jass, J.R., et al. Pathology of hereditary non-polyposis colorectal cancer. Anticancer Res 1994. 14(4B):1631–4.

    PubMed  CAS  Google Scholar 

  9. Sarroca, C., et al. Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay. Cancer Genet Cytogenet 2003. 142(1):13–20.

    Article  PubMed  CAS  Google Scholar 

  10. Wagner, A., et al. Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet 2003. 72(5):1088–100.

    Article  PubMed  CAS  Google Scholar 

  11. Wijnen, J., et al. MSH2 genomic deletions are a frequent cause of HNPCC. Nat Genet 1998. 20(4):326–8.

    Article  PubMed  CAS  Google Scholar 

  12. Vasen, H.F., Mecklin, J.P., Khan, P.M., Lynch, H.T. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991. 34:424–5.

    Article  PubMed  CAS  Google Scholar 

  13. Vasen, H.F., Watson, P., Mecklin, J.P., Lynch, H.T. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the INternaltional Collaborative group on HNPCC. Gastroenterology 1999. 116:1453–6.

    Article  PubMed  CAS  Google Scholar 

  14. Umar, A., et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004. 96(4):261–8.

    Article  PubMed  CAS  Google Scholar 

  15. Lindor, N.M., et al. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 2005. 293(16):1979–85.

    Article  PubMed  CAS  Google Scholar 

  16. Wijnen, J.T., et al. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. N Engl J Med 1998. 339(8):511–8.

    Article  PubMed  CAS  Google Scholar 

  17. Mueller-Koch, Y., et al. Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer. Gut 2005. 54(12):1733–40.

    Article  PubMed  CAS  Google Scholar 

  18. Lindor, N.M., et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA 2006. 296(12):1507–17.

    Article  PubMed  CAS  Google Scholar 

  19. Smith, R.A. et al. American Cancer Society. American Cancer Society guidelines for the early detection of cancer. Cancer J Clin 2004. 54:41–52.

    Article  Google Scholar 

  20. National Comprehensive Cancer Network. National Comprehensive Cancer Network Practice Guidelines in Oncology, 2004.

    Google Scholar 

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Correspondence to Deborah A. Nagle .

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Nagle, D.A., Poylin, V. (2011). Familial Colorectal Cancer Type X. In: Ellis, C. (eds) Inherited Cancer Syndromes. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6821-0_6

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  • DOI: https://doi.org/10.1007/978-1-4419-6821-0_6

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