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Cancer and Genetic Counseling

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Inherited Cancer Syndromes

Abstract

All cancer is genetic. Cancer is a disease caused by an accumulation of genetic damage that interferes with the regulation of cell growth, differentiation, and death. Most cancer-causing genetic damage is acquired either due to environmental exposures, carcinogens, or chance.

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References

  1. Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet Med 11, 35–41 (2009).

    Google Scholar 

  2. Khatcheressian, J.L. et al. American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting. J Clin Oncol 24, 5091–7 (2006).

    Article  PubMed  Google Scholar 

  3. Lancaster, J.M. et al. Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol 107, 159–62 (2007).

    Article  PubMed  Google Scholar 

  4. Murphy, C.D. et al. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 113, 3116–20 (2008).

    Article  PubMed  Google Scholar 

  5. Winawer, S. et al. Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology 124, 544–60 (2003).

    Article  PubMed  Google Scholar 

  6. Trepanier, A. et al. Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors. J Genet Couns 13, 83–114 (2004).

    Article  PubMed  Google Scholar 

  7. Dudley-Brown, S. & Freivogel, M. Hereditary colorectal cancer in the gastroenterology clinic: how common are at-risk patients and how do we find them? Gastroenterol Nurs 32, 8–16 (2009).

    Article  PubMed  Google Scholar 

  8. Mitchell, R.J. et al. Accuracy of reporting of family history of colorectal cancer. Gut 53, 291–5 (2004).

    Article  PubMed  CAS  Google Scholar 

  9. Church, J. & McGannon, E. Family history of colorectal cancer: how often and how accurately is it recorded? Dis Colon Rectum 43, 1540–4 (2000).

    Article  PubMed  CAS  Google Scholar 

  10. Lynch, H.T. et al. Who should be sent for genetic testing in hereditary colorectal cancer syndromes? J Clin Oncol 25, 3534–42 (2007).

    Article  PubMed  Google Scholar 

  11. Murff, H.J., Spigel, D.R. & Syngal, S. Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 292, 1480–9 (2004).

    Article  PubMed  CAS  Google Scholar 

  12. Tyler, C.V., Jr. & Snyder, C.W. Cancer risk assessment: examining the family physician’s role. J Am Board Fam Med 19, 468–77 (2006).

    Article  PubMed  Google Scholar 

  13. Mitchell, R.J. et al. Prevalence of family history of colorectal cancer in the general population. Br J Surg 92, 1161–4 (2005).

    Article  PubMed  CAS  Google Scholar 

  14. Schneider, K.A. Counseling About Cancer: Strategies for Genetic Counseling, 333 (Wiley-Liss, Inc., New York, 2002).

    Google Scholar 

  15. Young, S.R. et al. The prevalence of BRCA mutations among young women with triple-negative breast cancer. BMC Cancer 9, 86 (2009).

    Article  PubMed  CAS  Google Scholar 

  16. Berry, D.A., Parmigiani, G., Sanchez, J., Schildkraut, J. & Winer, E. Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst 89, 227–38 (1997).

    Article  PubMed  CAS  Google Scholar 

  17. Couch, F.J. et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer. N Engl J Med 336, 1409–15 (1997).

    Article  PubMed  CAS  Google Scholar 

  18. Frank, T.S. et al. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 20, 1480–90 (2002).

    Article  PubMed  CAS  Google Scholar 

  19. Shattuck-Eidens, D. et al. BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing. JAMA 278, 1242–50 (1997).

    Article  PubMed  CAS  Google Scholar 

  20. Stoppa-Lyonnet, D. et al. BRCA1 sequence variations in 160 individuals referred to a breast/ovarian family cancer clinic. Institut Curie Breast Cancer Group. Am J Hum Genet 60, 1021–30 (1997).

    PubMed  CAS  Google Scholar 

  21. Tyrer, J., Duffy, S.W. & Cuzick, J. A breast cancer prediction model incorporating familial and personal risk factors. Stat Med 23, 1111–30 (2004).

    Article  PubMed  Google Scholar 

  22. Balmana, J. et al. Prediction of MLH1 and MSH2 mutations in Lynch syndrome. JAMA 296, 1469–78 (2006).

    Article  PubMed  CAS  Google Scholar 

  23. Barnetson, R.A. et al. Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. N Engl J Med 354, 2751–63 (2006).

    Article  PubMed  CAS  Google Scholar 

  24. Chen, S. et al. Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA 296, 1479–87 (2006).

    Article  PubMed  CAS  Google Scholar 

  25. Marroni, F. et al. A genetic model for determining MSH2 and MLH1 carrier probabilities based on family history and tumor microsatellite instability. Clin Genet 69, 254–62 (2006).

    Article  PubMed  CAS  Google Scholar 

  26. Wijnen, J.T. et al. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. N Engl J Med 339, 511–8 (1998).

    Article  PubMed  CAS  Google Scholar 

  27. Giardiello, F.M. et al. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med 336, 823–7 (1997).

    Article  PubMed  CAS  Google Scholar 

  28. GeneTests. Medical Genetics Information Resource. (University of Seattle, Washington, 1993–2009).

    Google Scholar 

  29. Brandi, M.L. et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86, 5658–71 (2001).

    Article  PubMed  CAS  Google Scholar 

  30. Aretz, S. et al. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. Hum Mutat 26, 513–9 (2005).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Brandie Heald .

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Heald, B., Church, J.M. (2011). Cancer and Genetic Counseling. In: Ellis, C. (eds) Inherited Cancer Syndromes. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6821-0_2

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  • DOI: https://doi.org/10.1007/978-1-4419-6821-0_2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-6820-3

  • Online ISBN: 978-1-4419-6821-0

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