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Crosstalks Between Myelinating Cells and the Axonal Cytoskeleton

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Cytoskeleton of the Nervous System

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 3))

Abstract

A constant and dynamic communication between axons and myelinating cells is necessary for the correct development, function, and maintenance of myelinated fibers. Recently, several studies highlighted the pivotal role of the axonal cytoskeleton in this reciprocal communication. In particular, myelinating cells control the radial axonal growth by regulating the expression, transport, and organization of the axonal cytoskeleton. Conversely, this latter modulates dimensions of the myelin sheath by controlling the axonal caliber. Here, we will review the main investigations contributing to a better understanding of how the axoskeleton and myelinating cells influence each other to optimize conduction properties of myelinated fibers.

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  1. Department of Psychiatry and Neuroscience, Laval University, Research Centre of CHUQ, 2705, boulevard Laurier, T-2-50, G1V 4G2, Québec (Québec), Canada

    Rodolphe Perrot

  2. Laboratoire Neurobiologie et Transgenèse, UPRES-EA3143, INSERM, Bâtiment Monteclair, CHU, 49033, Angers, France

    Joël Eyer

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  1. Rodolphe Perrot
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  2. Joël Eyer
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Correspondence to Joël Eyer .

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  1. Psychiatric Research, Nathan S. Kline Institute for, 140 Old Orangeburg Road, Orangeburg, 10962, New York, USA

    Ralph A. Nixon

  2. Psychiatric Research, Nathan S. Kline Institute for, 140 Old Orangeburg Road, Orangeburg, 10962, New York, USA

    Aidong Yuan

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Perrot, R., Eyer, J. (2011). Crosstalks Between Myelinating Cells and the Axonal Cytoskeleton. In: Nixon, R., Yuan, A. (eds) Cytoskeleton of the Nervous System. Advances in Neurobiology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6787-9_25

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