Statistics for Testing Gene–Environment Interaction
This chapter introduces a number of new gene–environment interaction measures and develop novel statistics that are based on these new gene–environment interaction measures. These new statistics are simple, less computationally intensive and easy to implement. It is hoped that these developments may open a new avenue for large-scale genome-wide gene–environment interaction analysis, deciphering the genetic and physiological meaning of gene–environment interactions and developing sophisticated statistical methods for unraveling gene–gene and gene–environment interactions leading to the development of human cancers.
KeywordsStatistics Testing interaction between gene and binary or continuous environment Cancer
M. Xiong are supported by grants from the National Institutes of Health NIAMS P01 AR052915-01A1 and NIAMS R01AR057120-01.
- Anderson TW (1984) An introduction to multivariate statistical analysis, 2nd Edition. John Wiley & Sons, New York.Google Scholar
- Andrew AS, Mason RA, Kelsey KT, Schned AR, Marsit CJ, Nelson HH, Karagas MR (2009) DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicol Lett. 187(1):10–4.Google Scholar
- Brillinger DR (2004) Some data analyses using mutual information. Braz J Probab Stat. 18:163–83.Google Scholar
- Goodman M, Dana Flanders W (2007) Study design options in evaluating gene–environment interactions: practical considerations for a planned case-control study of pediatric leukemia. Pediatr Blood Cancer. 48(4):375–9.Google Scholar
- Jakulin A (2005) Machine learning based on attribute interaction. Ph.D. Dissertation, University of Ljubljana, Sezana.Google Scholar
- Johnson RA, Wichern DW (2002) Applied multivariate statistical analysis, 5th Edition. Prentice Hall, Upper Saddle River, NJ.Google Scholar
- Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC (2009). Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis. 30:472–9.PubMedCrossRefGoogle Scholar