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Statistics for Testing Gene–Environment Interaction

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Environmental Factors, Genes, and the Development of Human Cancers

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Abstract

This chapter introduces a number of new gene–environment interaction measures and develop novel statistics that are based on these new gene–environment interaction measures. These new statistics are simple, less computationally intensive and easy to implement. It is hoped that these developments may open a new avenue for large-scale genome-wide gene–environment interaction analysis, deciphering the genetic and physiological meaning of gene–environment interactions and developing sophisticated statistical methods for unraveling gene–gene and gene–environment interactions leading to the development of human cancers.

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Acknowledgments

M. Xiong are supported by grants from the National Institutes of Health NIAMS P01 AR052915-01A1 and NIAMS R01AR057120-01.

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Authors and Affiliations

  1. School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 77225, USA

    Momiao Xiong

  2. Department of Epidemiology and Statistics, Bengbu Medical College, Bengbu, Anhui, 233030, China

    Xuesen Wu

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  1. Momiao Xiong
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  2. Xuesen Wu
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Correspondence to Momiao Xiong .

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Editors and Affiliations

  1. Robert Stempel School of Public Health, Dept. Environmental & Occupational Healt, Florida International University, SW. 8th Street 11200, Miami, 33199-0001, Florida, USA

    Deodutta Roy

  2. Robert Stempel College of Public Health, Department of Environmental and Occupati, Florida International University, Miami, 33199-0001, Florida, USA

    M. Tevfik Dorak

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Xiong, M., Wu, X. (2010). Statistics for Testing Gene–Environment Interaction. In: Roy, D., Dorak, M. (eds) Environmental Factors, Genes, and the Development of Human Cancers. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6752-7_3

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