Statistics for Testing Gene–Environment Interaction

Chapter

Abstract

This chapter introduces a number of new gene–environment interaction measures and develop novel statistics that are based on these new gene–environment interaction measures. These new statistics are simple, less computationally intensive and easy to implement. It is hoped that these developments may open a new avenue for large-scale genome-wide gene–environment interaction analysis, deciphering the genetic and physiological meaning of gene–environment interactions and developing sophisticated statistical methods for unraveling gene–gene and gene–environment interactions leading to the development of human cancers.

Keywords

Statistics Testing interaction between gene and binary or continuous environment Cancer 

Notes

Acknowledgments

M. Xiong are supported by grants from the National Institutes of Health NIAMS P01 AR052915-01A1 and NIAMS R01AR057120-01.

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Copyright information

© Springer Science+ Business Media, LLC 2010

Authors and Affiliations

  1. 1.School of Public HealthHuman Genetics Center, The University of Texas Health Science Center at HoustonHoustonUSA
  2. 2.Department of Epidemiology and StatisticsBengbu Medical CollegeBengbuChina

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