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Ceramide Synthases: Roles in Cell Physiology and Signaling

  • Johnny Stiban
  • Rotem Tidhar
  • Anthony H. Futerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 688)

Abstract

Ceramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum. Six mammalian CerS have been described, with each utilizing fatty acyl CoAs of relatively defined chain lengths for N-acylation of the sphingoid long chain base. In this chapter, we review the main functional features of the CerS proteins, discuss their fatty acid specificity, kinetics, tissue distribution and mode of inhibition, as well as possible posttranslational modifications. We then address the reason that mammals contain six distinct CerS, whereas most other enzymes in the sphingolipid biosynthetic pathway only occur in one or two isoforms. Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease.

Keywords

Acyl Chain Arsenic Trioxide Ceramide Synthesis CerS Activity Ulatory Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Johnny Stiban
    • 1
  • Rotem Tidhar
    • 1
  • Anthony H. Futerman
    • 1
  1. 1.Department of Biological ChemistryWeizmann Institute of ScienceRehovotIsrael

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