Extracellular and Intracellular Actions of Sphingosine-1-Phosphate

  • Graham M. Strub
  • Michael Maceyka
  • Nitai C. Hait
  • Sheldon Milstien
  • Sarah Spiegel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 688)

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator with crucial roles in a wide variety of cellular functions across a broad range of organisms. Though a simple molecule in structure, S1P functions are complex. The formation of S1P is catalyzed by one of two sphingosine kinases that have differential cellular distributions as well as both overlapping and opposing functions and which are activated by many different stimuli. S1P can act on a family of G protein-coupled receptors (S1PRs) that are also differentially expressed in different cell types, which influences the cellular responses to S1P. In addition to acting on receptors located on the plasma membrane, S1P can also function inside the cell, independently of S1PRs. It also appears that both the intracellular location and the isotype of sphingosine kinase involved are major determinants of inside-out signaling of S1P in response to many extracellular stimuli. This chapter is focused on the current literature on extracellular and intracellular actions of S1P.

Keywords

PGE2 Saccharomyces Inositol Mast Mycobacterium 

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Graham M. Strub
    • 1
  • Michael Maceyka
    • 1
  • Nitai C. Hait
    • 1
  • Sheldon Milstien
    • 2
  • Sarah Spiegel
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyVCU School of MedicineRichmondUSA
  2. 2.National Institute of Mental HealthBethesdaUSA

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