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The Interplay between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis

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BCL-2 Protein Family

Part of the book series: Advances in Experimental Medicine and Biology ((volume 687))

Abstract

Apoptosis is a highly regulated process where key players such as BCL-2 family members control the recruitment of the mitochondrial subroutine. This culminates in the release of cytochrome c from the organelle in the cytoplasm, where it is required for the activation of effector caspases. The complete release of cytochrome c is the result of the combined action of proapoptotic BCL-2 family members and of changes in the complex morphology and ultrastructure of the organelle, controlled by the balance between fusion and fission processes. Here we discuss recent findings pointing to a role for changes in mitochondrial morphology during apoptosis and how these might be regulated by members of the BCL-2 family.

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Authors and Affiliations

  1. Department of Cell Physiology and Metabolism, University of Geneva Medical School, 1 Rue M. Servet, 1211, Genève, Switzerland

    Luca Scorrano

  2. Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy

    Maria Eugenia Soriano

Authors
  1. Maria Eugenia Soriano
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  2. Luca Scorrano
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Correspondence to Luca Scorrano .

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Editors and Affiliations

  1. Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile

    Claudio Hetz PhD

  2. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Claudio Hetz PhD

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Soriano, M.E., Scorrano, L. (2010). The Interplay between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis. In: Hetz, C. (eds) BCL-2 Protein Family. Advances in Experimental Medicine and Biology, vol 687. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6706-0_6

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