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Conjugation and Deconjugation of Ubiquitin Family Modifiers pp 158–169Cite as

Sumo Control

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 54))

Abstract

Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled. Sumoylation is a highly dynamic regulatory mechanism, involving an energy dependent enzyme cascade for conjugation and another set of enzymes for deconjugation. In this chapter we will highlight the different mechanisms controlling the SUMO system.

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Authors and Affiliations

  1. Max-Planck-Institute of Immunobiology, Stuebeweg 51, 79108, Freiburg, Germany

    Katharina Maderböck & Andrea Pichler

  2. Max F. Perutz Laboratories, Medical University Vienna, Dr. Bohrgasse 9, 1030, Wien, Austria

    Katharina Maderböck & Andrea Pichler

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  1. Katharina Maderböck
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  2. Andrea Pichler
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Correspondence to Andrea Pichler .

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  1. Department of Biology, Division of Immunology, University of Konstanz, Konstanz, Germany

    Marcus Groettrup PhD

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Maderböck, K., Pichler, A. (2010). Sumo Control. In: Groettrup, M. (eds) Conjugation and Deconjugation of Ubiquitin Family Modifiers. Subcellular Biochemistry, vol 54. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6676-6_13

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