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Perspective and Direction for Future Developments on Neurotraumatic and Neurodegenerative Diseases

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Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

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Abstract

Neurotraumatic and neurodegenerative diseases are mediated by synergistic action of excitotoxicity, oxidative stress, neuroinflammation, and misfolding and deposition of specific proteins in the brain tissue (Fig. 10.1) (Farooqui, 2009a). Among neurotraumatic diseases, the onset of stroke may be modulated by age, genes, diet, and lifestyle. Spinal cord injury (SCI) and traumatic brain injury (TBI) are caused by mechanical insults to the spinal cord and brain tissues (Farooqui and Horrocks, 2007), whereas stroke is a metabolic insult induced by severe reduction or blockade in cerebral blood flow. In contrast, neurodegenerative diseases occur in familial and sporadic forms. Familial mutations play an important role in protein misfolding and aggregation, but the majority of cases of neurodegenerative diseases are sporadic, indicating that other factors namely age, diet, lifestyle may also contribute to the pathogenesis of neurodegenerative diseases (Farooqui and Horrocks, 2007).

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References

  • Bass SD, Chen WK, Mulkem RV, Bakshi R (2006) Magnetic resonance imaging of iron deposition in neurological disorders. Top Magn Reson Imaging 17:31–40

    Article  Google Scholar 

  • Block ML, Hong J-S (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77–98

    Article  PubMed  CAS  Google Scholar 

  • Bray GA, Nielsen SJ, Popkin BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79:537–543

    PubMed  CAS  Google Scholar 

  • Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer’s disease in the United State and public health impact of delaying disease onset. Am J Public Health 88:1337–1342

    Article  PubMed  CAS  Google Scholar 

  • Caroli A, Frisoni GB (2009) Quantitative evaluation of Alzheimer’s disease. Expert Rev Med Devices 6:569–588

    Article  PubMed  Google Scholar 

  • Chen L, Wei Y, Wang X, He R (2009) D-Ribosylated Tau forms globular aggregates with high cytotoxicity. Cell Mol Life Sci 66:2559–2571

    Article  PubMed  CAS  Google Scholar 

  • Chen L, Wei Y, Wang X, He R (2010) Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS One 5(2):e9052

    Article  PubMed  Google Scholar 

  • Cogan JF, Mitchell OS (2003) Perspective from the President’s commission on Social Security Reform. J Econ Perspect 7:149–172

    Article  Google Scholar 

  • Cohen AD, Price JC, Weissfeld LA, James J, Rosario BL, Bi W, Nebes RD, Saxton JA, Snitz BE, Aizenstein HA, Wolk DA, Dekosky ST, Mathis CA, Klunk WE (2009) Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. J Neurosci 29:14770–14778

    Article  PubMed  CAS  Google Scholar 

  • Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O‘Keefe JH, Brand-Miller J (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81:341–354

    PubMed  CAS  Google Scholar 

  • Culmsee C, Landshamer S (2006) Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders. Curr Alzheimer Res 3:269–283

    Article  PubMed  CAS  Google Scholar 

  • de Leon MJ, DeSante S, Zinkowski R, Kerkman D, DeBermadis J, Li J, Lair L, Reiberg B, Tsui W, Rusinnek H (2004) MRI and CSF studies in the early diagnosis of Alzheimer’s disease. J Intern Med 256:205–223

    Article  PubMed  Google Scholar 

  • Eaton SB (2006) The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition? Proc Nutr Soc 65:1–6

    Article  PubMed  CAS  Google Scholar 

  • Farooqui AA, Horrocks LA (2007) Glycerophospholipids in brain. Springer, New York, NY

    Book  Google Scholar 

  • Farooqui AA, Horrocks LA, Farooqui T (2007a) Modulation of inflammation in brain: a matter of fat. J Neurochem 101:577–599

    Article  PubMed  CAS  Google Scholar 

  • Farooqui AA, Ong WY, Horrocks LA, Chen P, Farooqui T (2007b) Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. Brain Res Rev 56:443–471

    Article  PubMed  CAS  Google Scholar 

  • Farooqui AA, Ong WY, Horrocks LA (2008) Neurochemical aspects of excitotoxicity. Springer, New York, NY

    Google Scholar 

  • Farooqui T, Farooqui AA (2009) Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech Aging Dev 130:203–215

    Article  PubMed  CAS  Google Scholar 

  • Farooqui AA (2009a) Hot topics in neural membrane lipidology. Springer, New York, NY

    Book  Google Scholar 

  • Farooqui AA (2009b) Beneficial effects of fish oil on human brain. Springer, New York, NY

    Book  Google Scholar 

  • Finch CE, Sapolsky RM (1999) The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiol Aging 20:407–428

    Article  PubMed  CAS  Google Scholar 

  • Fleming JJ, England PM (2010) AMPA receptors and synaptic plasticity: a chemist’s perspective. Nat Chem Biol 6:89–97

    Article  PubMed  CAS  Google Scholar 

  • Gilgun-Sherki Y, Melamed E, Offen D (2006) Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state. Curr Pharmaceut Des 12:3509–3519

    Article  CAS  Google Scholar 

  • Gomez-Pinilla F (2008) Brain foods: the effects of nutrients on brain function. Nat Neurosci Rev 9:568–578

    Article  CAS  Google Scholar 

  • Hampel H, Burger K, Teipel SJ, Bokde AL, Zetterberg H, Blennow K (2008) Core candidate neurochemical and imaging biomarkers of Alzheimer’s disease. Alzheimers Dement 4:38–48

    Article  PubMed  CAS  Google Scholar 

  • Handley OJ, Naji JJ, Dunnett SB, Rosser AE (2006) Pharmaceutical, cellular and genetic therapies for Huntington’s disease. Clin Sci (Lond) 110:73–88

    Article  CAS  Google Scholar 

  • Hayashi T, Shoji M, Abe K (2006) Molecular mechanisms of ischemic neuronal cell death–with relevance to Alzheimer’s disease. Curr Alzheimer Disease 3:351–358

    Article  CAS  Google Scholar 

  • Henley SM, Bates GP, Tabrizi SJ (2005) Biomarkers for neurodegenerative diseases. Curr Opin Neurol 18:698–705

    Article  PubMed  Google Scholar 

  • Hodes RJ (2006) Public funding for Alzheimer’s disease research in United States. Nat Med 12:770–773

    Article  PubMed  CAS  Google Scholar 

  • Jin H, Randazzo J, Zhang P, Kador PF (2010) Multifunctional antioxidants for the treatment of age-related diseases. J Med Chem 53:1117–1127

    Article  PubMed  CAS  Google Scholar 

  • Kamphuis PJ, Wurtman RJ (2009) Nutrition and Alzheimer’s disease: pre-clinical concepts. Eur J Neurol 16(Suppl 1):12–18

    Article  PubMed  Google Scholar 

  • Langstrom B, Andren PE, Lindhe O, Svedberg M, Hall H (2007) In vitro imaging techniques in neurodegenerative diseases. Mol Imaging Biol 9:161–175

    Article  PubMed  Google Scholar 

  • Lu Y, Hong S, Gotlinger K, Serhan CN (2006) Lipid mediator informatics and proteomics in inflammation-resolution. Sci World J 6:589–614

    Article  CAS  Google Scholar 

  • Mattson MP, Duan W, Pedersen WA, Culmsee C (2001) Neurodegenerative disorders and ischemic brain diseases. Apoptosis 6:69–81

    Article  PubMed  CAS  Google Scholar 

  • Migliore L, Fontana I, Colognato R, Coppede F, Siciliano G, Murri L (2005) Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer’s disease and in other neurodegenerative diseases. Neurobiol Aging 26:587–595

    Article  PubMed  CAS  Google Scholar 

  • Miranda HV, Outerio TF (2009) The sour side of neurodegenerative disorders: the effects of protein glycation. J Pathol Dec 31 [Epub ahead of print]

    Google Scholar 

  • Molteni R, Bernard RJ, Ying Z, Roberts CK, Gomez-Pinilla F (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112:803–814

    Article  PubMed  CAS  Google Scholar 

  • Naigai Y, Fujikake N, Popiel HA, Wada K (2010) Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases. Curr Pharm Biotechnol Fab 16 [Epub ahead of print]

    Google Scholar 

  • Nile DY, Xu G, Ahmed S, Xiao ZC (2007) DNA vaccine and the CNS axonal regeneration. Curr Pharm Des 13:2500–2506

    Google Scholar 

  • Ono M (2007) Molecular imaging of beta-amyloid plaques in the brain. Brain Nerve 59:233–240

    PubMed  CAS  Google Scholar 

  • Palop JJ, Chin J, Mucke L (2006) A network dysfunction perspective on neurodegenerative diseases. Nature 443:768–773

    Article  PubMed  CAS  Google Scholar 

  • Pettegrew JW, Klunk WE, Kanal E, Panchalingam K, McClure RJ (1995) Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia. Neurobiol Aging 16:973–975

    Article  PubMed  CAS  Google Scholar 

  • Revill P, Moral MA, Prous JR (2006) Impaired insulin signaling and the pathogenesis of Alzheimer’s disease. Drug Today 42:785–790

    Article  CAS  Google Scholar 

  • Schmitt HP (2006) epsilon-Glycation, APP and Abeta in ageing and Alzheimer disease: a hypothesis. Med Hypotheses 66:698–906

    Article  Google Scholar 

  • Schneider P, Hampel H, Buerger K (2009) Biological marker candidates of Alzheimer’s disease in blood, plasma, and serum. CNS Neurosci Ther 15:358–374

    Article  PubMed  CAS  Google Scholar 

  • Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56:365–379

    Article  PubMed  CAS  Google Scholar 

  • Simopoulos AP (2006) Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 60:502–507

    Article  PubMed  CAS  Google Scholar 

  • Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, Barrio JR (2008) Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol 7:161–172

    Article  PubMed  Google Scholar 

  • Stranahan RS, Normal ED, Lee K, Cutler RG, Telljohan RS, Egan JM, Mattson MP (2008) Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 18:1085–1088

    Article  PubMed  Google Scholar 

  • Takeuchi M, Yamagishi S, Iwaki M, Nakamura K, Imaizumi T (2004) Advanced glycation end product (age) inhibitors and their therapeutic implications in diseases. Int J Clin Pharmacol 24:95–101

    CAS  Google Scholar 

  • Tan DX, Manchester LC, Sainz R, Mayo JC, Alvares FL, Reiter RJ (2003) Antioxidant strategies in protection against neurodegenerative disorders. Expert Opin Ther Patents 13:1513–1543

    Article  CAS  Google Scholar 

  • Thobois S, Guillouet S, Bronssolle E (2001) Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson’s disease. Neurophysiol Clin 31:321–340

    Article  PubMed  CAS  Google Scholar 

  • Trojanowski JQ (2008) PENN neurodegenerative disease research – in the spirit of Benjamin Franklin. Neurosignals 16:5–10

    Article  PubMed  CAS  Google Scholar 

  • Vemuri P, Wiste HJ, Weigand SD, Shaw LM, Trojanowski JQ, Weiner MW, Knopman DS, Petersen RC, Jack CR Jr Alzheimer’s Disease Neuroimaging Initiative (2009) MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change. Neurology 73:294–301

    Article  PubMed  CAS  Google Scholar 

  • Wang JY, Wen LL, Huang YN, Chen YT, Ku MC (2006) Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharmaceut Des 12:3521–3533

    Article  CAS  Google Scholar 

  • Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G (2006) Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein. J Mol Med 84:635–646

    Article  PubMed  CAS  Google Scholar 

  • Wood PL (1998) Neuroinflammation: mechanisms and management. Humana Press, Totowa, NJ

    Google Scholar 

  • Wurtman RJ, Cancev W, Sakamoto T, Ulus IH (2009) Use of phosphatide precursors to promote synaptogenesis. Annu Rev Nutri 29:59–87

    Article  CAS  Google Scholar 

  • Xie CW (2004) Calcium-regulated signaling pathways: role in amyloid β-induced synaptic dysfunction. Neuromolecular Med 6:53–64

    Article  PubMed  CAS  Google Scholar 

  • Xu G, Nie DY, Chen JT, Wang CY, Yu FG, Sun L, Luo XG, Ahmed S, Xiao ZC (2004) Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: a potential strategy for axonal regeneration. J Neurochem 91:1018–1023

    Article  PubMed  CAS  Google Scholar 

  • Yan SD, Bierhaus A, Nawroth PP, Stern DM (2009) RAGE and Alzheimer’s disease: a progression factor for amyloid-beta-induced cellular perturbation? J Alzheimer Res 16:833–843

    Google Scholar 

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  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Avenue, Columbus, OH, 43210, USA

    Akhlaq A. Farooqui

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Farooqui, A.A. (2010). Perspective and Direction for Future Developments on Neurotraumatic and Neurodegenerative Diseases. In: Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6652-0_10

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