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Perspective and Direction for Future Developments on Neurotraumatic and Neurodegenerative Diseases

  • Akhlaq A. Farooqui
Chapter

Abstract

Neurotraumatic and neurodegenerative diseases are mediated by synergistic action of excitotoxicity, oxidative stress, neuroinflammation, and misfolding and deposition of specific proteins in the brain tissue (Fig. 10.1) (Farooqui, 2009a). Among neurotraumatic diseases, the onset of stroke may be modulated by age, genes, diet, and lifestyle. Spinal cord injury (SCI) and traumatic brain injury (TBI) are caused by mechanical insults to the spinal cord and brain tissues (Farooqui and Horrocks, 2007), whereas stroke is a metabolic insult induced by severe reduction or blockade in cerebral blood flow. In contrast, neurodegenerative diseases occur in familial and sporadic forms. Familial mutations play an important role in protein misfolding and aggregation, but the majority of cases of neurodegenerative diseases are sporadic, indicating that other factors namely age, diet, lifestyle may also contribute to the pathogenesis of neurodegenerative diseases (Farooqui and Horrocks, 2007).

Keywords

Traumatic Brain Injury Spinal Cord Injury Single Photon Emission Compute Tomography Neurodegenerative Disease Alzheimer Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA

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