Hypertrophic Pyloric Stenosis



Hypertrophic pyloric stenosis (HPS) is an acquired disorder that presents in infants between 3 and 8 weeks of age. The radial smooth muscle of the pylorus undergoes concentric hypertrophy, which causes narrowing of the pyloric channel and produces a gastric outlet obstruction. The obstruction results in progressive, projectile, nonbilious emesis, which can lead to dehydration, metabolic alkalosis, weight loss, and hypoglycemia.


Muscle Thickness Pyloric Stenosis Metabolic Alkalosis Gastric Outlet Obstruction Hypertrophic Pyloric Stenosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

Suggested Reading

  1. Everett KV, Chioza BA, Georgoula C, Reece A, Capon F, Parker KA, et al. Genome-wide high-density SNP-based linkage analysis of infantile hypertrophic pyloric stenosis identifies loci on chromosomes 11q14-q22 and Xq23. Am J Hum Gen. 2008;82(3):756–62.CrossRefGoogle Scholar
  2. Hulka F, Harrison MW, Campbell TJ, Campbell JR. Complications of pyloromyotomy for infantile hypertrophic pyloric stenosis. Am J Surg. 1997;173(5):450–2.CrossRefPubMedGoogle Scholar
  3. Kim SS, Lau ST, Lee SL, Schaller R, Healey PJ, Ledbetter DJ, et al. Pyloromyotomy: A comparison of laparoscopic, circumbilical, and right upper quadrant operative techniques. J Am Coll Surg. 2005;201(1):66–9.CrossRefPubMedGoogle Scholar
  4. Ly DP, Liao JG, Burd RS. Effect of surgeon and hospital charac­teristics on outcome after pyloromyotomy. Arch Surg. 2005;140:1191–7.CrossRefPubMedGoogle Scholar
  5. MacMahon B. The continuing enigma of pyloric stenosis of infancy. Epidemiology. 2006;17(2):195–201.CrossRefPubMedGoogle Scholar
  6. Muramori K, Nagasake A, Kawanami T. Ultrasonographic serial ­measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric ­stenosis. J Ultrasound Med. 2007;26(12):1681–7.PubMedGoogle Scholar
  7. St Peter SD, Holcomb III GW, Calkins CM, Murphy JP, Andrews WS, Sharp RJ, et al. Open versus laparoscopic pyloromyotomy for pyloric stenosis: A prospective, randomized trial. Ann Surg. 2006;244:363–70.PubMedGoogle Scholar
  8. Vegunta RK, Woodland JH, Rawlings AL, Wallace LJ, Pearl RH. Practice makes perfect: Progressive improvement of laparoscopic pyloromyotomy results, with experience. J Laparoendoc Adv Surg Tech. 2008;18(1):152–6.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of SurgeryMedical College of Wisconsin, Children’s Hospital of WisconsinMilwaukeeUSA

Personalised recommendations