Intestinal Transplantation

  • Thomas M. Fishbein


Intestinal transplantation is increasingly accepted as standard therapy for patients who develop intestinal and parenteral nutrition failure. While early attempts at intestinal transplantation more than 40 years ago met with limited success, progress has led to clinical success that parallels other solid-organ transplants. Intestinal transplants are now performed for children who suffer a failure of gut function from a variety of causes. In such cases, the state of nutritional failure is irreversible and no other therapy can guarantee long-term survival. In rare instances, gut function can be preserved, but anatomical defects, such as congenital malformation or mesenteric tumors require exenteration in order to preserve life. Thus, candidates fail parenteral nutrition, cannot adapt to life on parenteral nutrition, or require removal of the native gut in order to survive.


Parenteral Nutrition Superior Mesenteric Artery Short Bowel Syndrome Intestinal Transplantation Intestinal Failure 
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Suggested Reading

  1. Abu-Elmagd K, Fung J, Bueno J, et al. Logistics and technique for ­procurement of intestinal, pancreatic, and hepatic grafts from the same donor. Ann Surg. 2000;232:680–7.CrossRefPubMedGoogle Scholar
  2. Fishbein TM, Gondolesi GE, Kaufman SS. Intestinal transplantation for gut failure. Gastroenterology. 2003a;124:1615–28.CrossRefPubMedGoogle Scholar
  3. Fishbein TM, Kaufman SS, Florman S, et al. Isolated intestinal transplantation: proof of efficacy. Transplantation. 2003b;76:636–40.CrossRefPubMedGoogle Scholar
  4. Reyes J, Mazariegos GV, Bond GM, et al. Pediatric intestinal transplantation: historical notes, principles and controversies. Pediatr Transplant. 2002;6:193–207.CrossRefPubMedGoogle Scholar
  5. Starzl TE, Todo S, Tzakis AG, et al. The many faces of multivisceral transplantation. Surg Gynecol Obstet. 1991;172:335–44.PubMedGoogle Scholar
  6. Sudan D. Cost and quality of life after intestinal transplantation. Gastroenterology. 2006;130:S158–62.CrossRefPubMedGoogle Scholar
  7. Todo S, Tzakis AG, Abu-Elmagd K, et al. Intestinal transplantation in composite visceral grafts or alone. Ann Surg. 1992;216:223–34.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Transplant InstituteGeorgetown University HospitalWashingtonUSA

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