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Fungal Infections Among Patients with AIDS

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Essentials of Clinical Mycology

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Abstract

Fungal infections are the most frequent opportunistic ­diseases occurring during the course of HIV infection. Those mycoses that are usually controlled by cellular immunity are most commonly observed. However, in patients with AIDS, the immune deficit is complex and worsens with time in untreated patients, allowing mycotic diseases to develop [1–3]. Pneumocystis jiroveci and Candida albicans, which are responsible for mucosal candidiasis, and Cryptococcus neoformans, the most frequent cause of meningitis, are the three major fungal pathogens in patients with AIDS [4, 5]. In endemic areas, infections due to dimorphic fungi also ­represent an important group. Histoplasma capsulatum, Coccidioides species, and Penicillium marneffei are the most important endemic pathogens. In some AIDS patients, mycotic disease is often the consequence of reactivation ­several years after a primary infection [6].

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Authors and Affiliations

  1. Infectious and Tropical Diseases Departement, Centre d’ Infectiologie Necker-Pasteur, Université Paris Descartes, Hôpital Necker Enfants malades, Paris, France

    Olivier Lortholary

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  1. Olivier Lortholary
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  2. Bertrand Dupont
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Correspondence to Olivier Lortholary .

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Editors and Affiliations

  1. Veterans Affairs Ann Arbor Healthcare, Professor of Internal Medicine, University of Michigan Medical School, 2215 Fuller Road, Ann Arbor, 48105, Michigan, USA

    Carol A. Kauffman

  2. Division of Infectious Diseases, University of Alabama at Birmingham, 1900 University Blvd., Birmingham, 35294, Alabama, USA

    Peter G. Pappas

  3. Division of Infectious Diseases, Wayne State University School of Medicin, 3990 John R Street, Detroit, 48201, Michigan, USA

    Jack D. Sobel

  4. School of Medicine, Professor Emeritus of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, 35294, Alabama, USA

    William E. Dismukes

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Lortholary, O., Dupont, B. (2011). Fungal Infections Among Patients with AIDS. In: Kauffman, C., Pappas, P., Sobel, J., Dismukes, W. (eds) Essentials of Clinical Mycology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6640-7_31

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