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Glycolytic Pathway as a Target for Tumor Inhibition

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Book cover The Tumor Microenvironment

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

It has been known for decades that cancer cells exhibit elevated aerobic glycolysis, a phenomenon first observed by Otto Warburg. The imaging technique 18fluoro-deoxyglucose-positron emission tomography (FDG-PET) widely used in clinical diagnosis of cancer is based on the increased glucose uptake by cancer cells, likely due to a significant increase in glucose flow into the glycolytic pathway to generate ATP and conversion to other metabolic intermediates and building blocks for cell growth and proliferation. Furthermore, the increased glucose uptake in cancer tissues seems correlated with tumor aggressiveness and poor prognosis. Such profound metabolic alterations suggest that cancer cells may prefer to use glycolysis for their proliferative and survival advantage. Recent studies have begun to elucidate the molecular mechanisms underlying these metabolic alterations, and provide important new insights into the mechanistic links between oncogenic signals and metabolic regulation. Importantly, targeted inhibition of glycolysis and its regulatory pathways may provide exciting opportunities for the development of therapeutic strategies to preferentially kill cancer cells. This chapter will summarize our current understanding of glycolytic alterations in cancer cells and the relevant regulatory mechanisms, and discuss possible therapeutic strategies that exploit the metabolic abnormalities in cancer to preferentially kill malignant cells.

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  1. Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Peng Huang

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  1. Weiqin Lu
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    Rebecca G. Bagley

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Lu, W., Huang, P. (2010). Glycolytic Pathway as a Target for Tumor Inhibition. In: Bagley, R. (eds) The Tumor Microenvironment. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6615-5_5

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