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Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment

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The Tumor Microenvironment

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Majority of cancer patients will die of metastases that develop from disseminated tumor cells (DTCs), months, years, or even decades after treatment. This pause in cancer progression suggests that, during these disease-free periods, DTCs may stop proliferating and survive in a dormant state. The mechanisms that determine whether tumor cells, after disseminating to target organs, will continue to proliferate, die or enter a protracted state of dormancy are poorly understood. Here, we review the different manifestations of dormancy and the experimental and clinical evidence supporting that the target organ microenvironment where DTCs lodge might influence the choice to enter dormancy. We also review the available animal models to study DTCs dormancy. This information is important to design strategies to maintain dormancy of DTCs or eradicate DTCs before they progress to overt metastasis. Such information would lead to anti-metastatic and/or metastasis preventive therapies which are urgently needed.

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Acknowledgments

This work was supported by grants from the Samuel Waxman Cancer Research Foundation Tumor Dormancy Program (to JAG), NIH/NCI (CA109182 to JAG), NIEHS (ES017146 to JAG), New York State Stem Cell Science – NYSTEM (to JAG) and NIDCR (DE020121 to AR).

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  1. Division of Hematology and Oncology, Departments of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, 1079, New York, NY, 10029, USA

    Julio A. Aguirre-Ghiso

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  1. Paloma Bragado
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  2. Aparna C. Ranganathan
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  3. Julio A. Aguirre-Ghiso
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Correspondence to Julio A. Aguirre-Ghiso .

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  1. Genzyme Corporation, Mountain Rd. 1, Framingham, 01701-9322, Massachusetts, USA

    Rebecca G. Bagley

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Bragado, P., Ranganathan, A.C., Aguirre-Ghiso, J.A. (2010). Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment. In: Bagley, R. (eds) The Tumor Microenvironment. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6615-5_11

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