Abstract
The diversification of the TNF superfamily in regulating lymphocyte function is astounding. This diversity of function is reflected in genetic expansion and linkage of several TNFR within conserved immune response loci. Several TNFR, including TNFR2, HVEM, OX40, 41BB, and DR3 reside on Chromosome 1p36, and their ligands retained as functional paralogs of the MHC gene complex on Chromosome 6. These TNF superfamily genes encode the molecules that control intercellular communication pathways involved primarily in regulating cellular immunity. In this session, the science presented underscored the diversity of roles played by the TNF superfamily in regulating lymphocyte function.
2009 TNF Conference Proceedings
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Ware, C.F., Browning, J.L. (2011). Workshop Summary: Control of Lymphocyte Function and Repertoire by the TNF Superfamily. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_35
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DOI: https://doi.org/10.1007/978-1-4419-6612-4_35
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