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TWEAK and the Kidney: the Dual Role of a Multifunctional Cytokine

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Book cover Advances in TNF Family Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

Acute kidney injury (AKI) is a syndrome characterized by an acute loss of renal function. The incidence of AKI is 208 per million population in Europe. There is no established therapy to accelerate the recovery and attempts at preventing AKI are not universally effective. The treatment of most forms of AKI is symptomatic and consists in substitution of renal function by dialysis if renal failure is severe. Despite the reversibility of the loss of renal function in most patients that survive, the mortality of AKI remains high (over 50%) [41].The tubular epithelium is a key cell in the renal injury. Indeed, tubular cell death plays an important role in the AKI and is the main histological correlation with the degree of renal failure [37, 51]. The tubular epithelium also contributes to renal failure by secreting pro-inflammatory cytokines and by the epithelium–mesenchymal differentiation originating fibroblasts and promoting tubular atrophy and interstitial fibrosis [40, 54]. These events are important contributors to progression of chronic kidney disease.

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Acknowledgments

Grant support: FIS CP04/00060, 06/0046, SAF03/884, SAF2005-03378, SAF2007/60896, Sociedad Española de Nefrologia, ISCIII-RETIC REDinREN/RD06/0016, Comunidad de Madrid/FRACM/S-BIO0283/2006, and SAF 2007-60896. Salary support: FIS to MCI and AS, MEC to MDSN, and Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to AO.

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Authors and Affiliations

  1. Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain

    Ana Ortiz, M.D. Sanchez-Niño, M.C. Izquierdo, L.M. Blanco-Colio, M. Ruiz-Ortega & J. Egido

  2. Servicio de Nefrologia, Fundación para la Investigación Biomédica del Hospital Universitario La Paz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain

    R. Selgas

  3. Laboratory of Nephrology, Fundación para la Investigación Biomédica del Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain

    Ana B. Sanz

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  1. Ana Ortiz
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  2. M.D. Sanchez-Niño
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  3. M.C. Izquierdo
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  4. L.M. Blanco-Colio
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  6. M. Ruiz-Ortega
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  8. Ana B. Sanz
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Correspondence to Ana B. Sanz .

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Editors and Affiliations

  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Ortiz, A. et al. (2011). TWEAK and the Kidney: the Dual Role of a Multifunctional Cytokine. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_33

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