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The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse

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Book cover Advances in TNF Family Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

Tissues subjected to stress, for example due to mechanical injury, environmental exposures, or endogenous signals, possess a remarkable ability to respond, adapting to limit stress, protect the tissue from further injury, and promote normal tissue recovery. This involves the coordinated activation and regulation of multiple processes, including infiltration by inflammatory cells to remove damaged cells and debris, angiogenesis, extracellular matrix turnover, and progenitor cell expansion and differentiation to regenerate normal tissue. However, in some circumstances inappropriate tissue responses occur, for example acute or prolonged overreactions, wherein the underlying processes are exaggerated and dysregulated, resulting in maladaptive tissue remodeling. A prominent feature of such pathological tissue responses is robust inflammation, as occurs in chronic autoimmune and inflammatory diseases, leading to cell death, progressive damage, and pathological remodeling of the disease target tissue. In the past decade, the ctokine TWEAK and its receptor FN14 have emerged as a ligand/receptor pair of the TNF superfamily that is prominently featured in normal and pathological tissue remodeling. TWEAK/Fn14-induced activities contribute to progressive local tissue damage, maladaptive remodeling, and worsened outcomes in animal models of inflammatory disease.

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Author information

Authors and Affiliations

  1. Biogen Idec, Inc., Cambridge, MA, USA

    Linda C. Burkly

  2. Research Institute, National Center of Global Health and Medicine, Tokyo, Japan

    Taeko Dohi

Authors
  1. Linda C. Burkly
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  2. Taeko Dohi
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Correspondence to Linda C. Burkly .

Editor information

Editors and Affiliations

  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Burkly, L.C., Dohi, T. (2011). The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_32

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