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Introductory Words About TL1A/DR3

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Advances in TNF Family Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

TL1A, a protein member of the tumor necrosis factor superfamily 15 (TNFSF15), signaling through its receptor DR3, has been defined as a master regulatory cytokine that plays a key role in human intestinal inflammation. Recent studies have also defined a critical role for TL1A in the pathogenesis of mouse experimental autoimmune encephalomyelitis (EAE), models of allergic lung inflammation and human rheumatoid arthritis. The initial discovery of TL1A has given way to subsequent genetic, human, and animal investigation at the bench and will reach the bedside in the form of a clinical trial in 2011–2012. Furthermore, TNFSF15 and TL1A fit superbly into the personalized medicine paradigm, in which the combination of genetic, biologic, and micro-environmental information may well combine to inform the design of a therapeutic for the subgroup of Crohn’s disease patients that will be uniquely likely to benefit.

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Author information

Authors and Affiliations

  1. Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Suite D4063, Los Angeles, CA, 90048, USA

    Stephan R. Targan

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  1. Stephan R. Targan
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Correspondence to Stephan R. Targan .

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Editors and Affiliations

  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Targan, S.R. (2011). Introductory Words About TL1A/DR3. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_27

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