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Advances in TNF Family Research pp 231–249Cite as

Lymphotoxin’s Link to Carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

Tumor necrosis factor alpha (TNFα) was initially discovered due to its tumor necrotizing activity in mice, leading to the death of vascular endothelial cells. Today, pro- and anti-tumorigenic effects of TNF are discussed and TNF as well as other members of the TNF superfamily (TNFSF) were described to play an important role in the development and maintenance of lymphoid tissue and inflammatory reactions. Notably, recent reports indicate a pivotal role of lymphotoxin (LT), a closely related cytokine, in controlling the development of liver and prostate cancer or nasopharyngeal carcinoma – however by distinct mechanisms. Here, we review the pleiotropic functions attributed to LT, the effects of its deregulation and discuss recent literature on LT’s link to cancer.

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Acknowledgments

We thank Dr. Johannes Haybaeck and Barbara Stecher as well as Jay Tracy for critically reading this chapter. MH is supported by grants of the Oncosuisse Foundation OCS 02113-08-2007, the Novartis Stiftung für Biologisch-Medizinische Forschung (no. 09C62), the “Stiftung zur Schweizerischen Krebsbekämpfung,” the research foundation at the Medical Faculty Zurich, and the “Kurt und Senta Hermann Stiftung.” MJW was supported by a grant of the Roche Research Foundation. MH is a fellow of the Prof. Dr. Max Cloëtta Foundation.

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Authors and Affiliations

  1. Department of Pathology, Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

    Monika Julia Wolf & Gitta Maria Seleznik

  2. Department of Pathology, University Hospital Zurich, CH 8091, Zurich, Switzerland

    Mathias Heikenwalder

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  1. Monika Julia Wolf
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Correspondence to Mathias Heikenwalder .

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  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Wolf, M.J., Seleznik, G.M., Heikenwalder, M. (2011). Lymphotoxin’s Link to Carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_24

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