MUTYH-Associated Polyposis

  • Jeremy P. CheadleEmail author
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)


MUTYH-associated polyposis (MAP) is an autosomal recessive disorder characterised by multiple colorectal adenomas and carcinoma. It is caused by inherited mutations in the human MutY homologue gene (MUTYH). MUTYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2’-deoxyguanosine, one of the most stable products of oxidative DNA damage. The failure to correct this mispair is thought to cause the characteristic signature of G:C to T:A mutations found in MAP-associated tumours.


MUTYH MYH MAP Colorectal cancer APC FAP 



Professor Cheadle is supported by Cancer Research UK, Cancer Research Wales and the Wales Gene Park.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Institute of Medical GeneticsCardiff UniversityCardiffUK

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