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DNA Mismatch Repair

  • C. Richard BolandEmail author
Chapter
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)

Abstract

The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of cells. These systems are essential for the faithful replication of the genome, and germline defects in these systems give rise to familial cancer syndromes, each with a unique spectrum of neoplasia.

Keywords

DNA mismatch repair Mutation Microsatellite instability MSH2 MLH1 MSH6 PMS2 Lynch syndrome Exonuclease 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.GastroenterologyBaylor University Medical CenterDallasUSA

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