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Across Culture and Health Systems: Korea

  • Duck-Woo Kim
  • Jae-Gahb ParkEmail author
Chapter
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)

Abstract

Hereditary colorectal cancer in Korea will be described in this chapter. Particular emphasis on the establishment and activities of the Korean Hereditary Tumor Registry will be given. The Korean Health Insurance System including support for genetic testing and the National Cancer Screening Program will also be discussed.

Keywords

Across Culture Health System Hereditary Colorectal Cancer Korea 

References

  1. 1.
    Park JG, editor. Cancer incidence in Korea: 1999–2001. Goyang: National Cancer Center; 2005.Google Scholar
  2. 2.
    Korea Central Cancer Registry. 2002 Annual report of the Korea Central Cancer Registry, based-on registered data from 139 hospitals. Goyang: National Cancer Center; 2003.Google Scholar
  3. 3.
    Bussey HJR. Historical development in familial adenomatous polyposis. In: Herera L, editor. Familial adenomatous polyposis. New York: Alan R. Liss Inc.; 1990. p. 1–7.Google Scholar
  4. 4.
    Vasen HFA, den Harrog Jager FCA, Nagengast FM, et al. Screening for hereditary non-polyposis colorectal cancer in the Netherlands. In: Utsunomiya J, Lynch HT, editors. Hereditary colorectal cancer. Tokyo: Springer; 1995. p. 143–9.Google Scholar
  5. 5.
    Park JG, Han HJ, Won YJ, et al. Familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer in Korea. In: Baba S, editor. New strategies for treatment of hereditary colorectal cancer. Tokyo: Churchill Livingstone; 1996. p. 213–28.Google Scholar
  6. 6.
    Park JG, Park KJ, Won CK, et al. Polyposis coli syndrome in Koreans. J Korean Soc Coloproctol. 1991;7:1–13.Google Scholar
  7. 7.
    Vasen HFA, Mecklin J-P, Meera Khan P, et al. The international collaboratory group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum. 1991;34:424–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Seo JM, Park JG, Kim SJ, et al. Hereditary nonpolyposis colorectal cancer: report of one case. J Korean Soc Coloproctol. 1991;7:155–62.Google Scholar
  9. 9.
    Kang HC, Kim IJ, Park JG, et al. Germline mutations of BRCA1 and BRCA2 in Korean breast and/or ovarian cancer families. Hum Mutat. 2002;20:235.PubMedCrossRefGoogle Scholar
  10. 10.
    Won YJ, Oh JH, Park JG, et al. Germline mutation of BRCA2 gene in Korean breast/ovarian cancer families. J Korean Cancer Assoc. 1998;30:242–52.Google Scholar
  11. 11.
    Kang SB, Kweon JH, Park JG, et al. Hereditary ovarian cancer: report of 6 families. Korean J Gynecol Oncol Colposc. 1995;6:204–13.Google Scholar
  12. 12.
    Grady WM, Willis J, Park JG, et al. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nat Genet. 2000;26:16–7.PubMedCrossRefGoogle Scholar
  13. 13.
    Park JG, Yang HK, Kim WH, et al. Report on the first meeting of the international collaborative group on herediatry gastric cancer. J Natl Cancer Inst. 2000;92:1781–2.PubMedCrossRefGoogle Scholar
  14. 14.
    Kim IJ, Park JH, Park JG, et al. A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer. J Med Genet. 2003;40:e97.PubMedCrossRefGoogle Scholar
  15. 15.
    Kim IJ, Kang HC, Park JG, et al. A TP53-truncating germline mutation (E287X) in a family with characteristics of both hereditary diffuse gastric cancer and Li-Fraumeni syndrome. J Hum Genet. 2004;49:591–5.PubMedCrossRefGoogle Scholar
  16. 16.
    Ku JL, Yu YS, Park JG. Germline mutation of Rb1 gene in Korean retinoblastoma patients. J Korean Cancer Assoc. 1997;29:291–8.Google Scholar
  17. 17.
    Yu YS, Kim IJ, Park JG, et al. Identification of four novel RB1 germline mutations in Korean retinoblastoma patients. Hum Mutat. 2001;18:252.PubMedCrossRefGoogle Scholar
  18. 18.
    Yang HJ, Won YJ, Park JG, et al. Germline mutations of the NF2 gene in Korean neurofibromatosis 2 patient. J Korean Cancer Assoc. 1998;30:790–9.Google Scholar
  19. 19.
    Park KJ, Shin KH, Park JG, et al. Germline mutations in the EXT1 and EXT2 genes in Korean patients with hereditary multiple exostoses. J Hum Genet. 1999;44:230–4.PubMedCrossRefGoogle Scholar
  20. 20.
    Park JH, Kim IJ, Park JG, et al. Germline mutations of MEN1 gene in Korean families with multiple endocrine neoplasia type1(MEN1) or MEN1-related disorders. Clin Genet. 2003;64:48–53.PubMedCrossRefGoogle Scholar
  21. 21.
    Kang HC, Kim IJ, Park JG, et al. Three novel VHL germline mutations in Korean patients with von Hippel–Lindau disease and pheochromocytomas. Oncol Rep. 2005;14:879–83.PubMedGoogle Scholar
  22. 22.
    Park JG, Han HJ, Kang MS, et al. Presymptomatic diagnosis of familial adenomatous polyposis coli. Dis Colon Rectum. 1994;37:700–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Won YJ, Park KJ, Park JG, et al. Germline mutations of the APC gene in Korean familial adenomatous polyposis patients. J Hum Genet. 1999;44:103–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Kim DW, Kim IJ, Park JG, et al. Mutation spectrum of the APC gene in 83 Korean FAP families. Hum Mutat. 2005;26:281.PubMedCrossRefGoogle Scholar
  25. 25.
    Shin YK, Heo SC, Park JG, et al. Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families. Hum Mutat. 2004;24:351.PubMedCrossRefGoogle Scholar
  26. 26.
    Han HJ, Maruyama M, Park JG, et al. Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC). Hum Mol Genet. 1995;4:237–42.PubMedCrossRefGoogle Scholar
  27. 27.
    Han HJ, Yuan Y, Park JG, et al. Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst. 1996;88:1317–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Yuan Y, Han HJ, Park JG, et al. Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer. Dis Colon Rectum. 1998;41:434–40.PubMedCrossRefGoogle Scholar
  29. 29.
    Shin KH, Ku JL, Park JG. Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. J Hum Genet. 1999;44:18–21.PubMedCrossRefGoogle Scholar
  30. 30.
    Shin KH, Shin JH, Park JG, et al. Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. Cancer Res. 2002;62:38–42.PubMedGoogle Scholar
  31. 31.
    Park JG, Vasen HF, Park KJ, et al. Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. Dis Colon Rectum. 1999;42:710–5.PubMedCrossRefGoogle Scholar
  32. 32.
    Park JG, Vasen HF, Park YJ, et al. Suspected HNPCC and Amsterdam criteria II: evaluation of mutation detection rate, an international collaborative study. Int J Colorectal Dis. 2002;17:109–14.PubMedCrossRefGoogle Scholar
  33. 33.
    Lee EJ, Park YJ, Park JG, et al. Clinical aspects of suspected HNPCC in Korea. J Korean Soc Coloproctol. 1998;14:331–9.Google Scholar
  34. 34.
    Park JG, Park KJ, Ahn YO, et al. Risk of gastric cancer among Korean familial adenomatous polyposis patients. Reports of three cases. Dis Colon Rectum. 1992;35:996–8.PubMedCrossRefGoogle Scholar
  35. 35.
    Park YJ, Shin KH, Park JG. Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea. Clin Cancer Res. 2000;6:2994–8.PubMedGoogle Scholar
  36. 36.
    Choi HS, Park YJ, Park JG, et al. Clinical characteristics of Peutz–Jeghers syndrome in Korean polyposis patients. Int J Colorectal Dis. 2000;15:35–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Yoon KA, Ku JL, Park JG, et al. Germline mutations of the STK11 gene in Korean Peutz–Jeghers syndrome patients. Br J Cancer. 2000;82:1403–6.PubMedGoogle Scholar
  38. 38.
    Kim IJ, Ku JL, Park JG, et al. Germline mutations of the dpc4 gene in Korean juvenile polyposis patients. Int J Cancer. 2000;86:529–32.PubMedCrossRefGoogle Scholar
  39. 39.
    Kim IJ, Park JH, Park JG, et al. Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation. Clin Genet. 2003;63:126–30.PubMedCrossRefGoogle Scholar
  40. 40.
    Al-Tassan N, Chmiel NH, Maynard J, et al. Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors. Nat Genet. 2002;30:227–32.PubMedCrossRefGoogle Scholar
  41. 41.
    Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med. 2003;348:791–9.PubMedCrossRefGoogle Scholar
  42. 42.
    Wang L, Baudhuin LM, Boardman LA, et al. MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. Gastroenterology. 2004;127:9–16.PubMedCrossRefGoogle Scholar
  43. 43.
    Venesio T, Molatore S, Cattaneo F, et al. High frequency of MYH gene mutations in a subset of patients with familial adenomatous polyposis. Gastroenterology. 2004;126:1681–5.PubMedCrossRefGoogle Scholar
  44. 44.
    Kim DW, Kim IJ, Park JG, et al. Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas. Int J Colorectal Dis. 2007;22(10):1173–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research CenterSeoul National University College of MedicineSeoulKorea

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