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Molecular Genetics of Familial Adenomatous Polyposis

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Hereditary Colorectal Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA,volume 5))

Abstract

With the advances in molecular genetics, the function of the APC gene has been and still is being described. In this chapter, a description of the APC protein, function, its relation to tumorigenesis, Familial Adenomatous Polyposis and other colorectal cancer syndromes will be discussed. Finally animal models which have been proven invaluable in the discovery of the APC protein function, will be described.

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Authors and Affiliations

  1. Molecular and Population Genetics Laboratory, Cancer Research UK London Research Institute, London, UK

    Ian P. Tomlinson

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  1. Luis G. Carvajal-Carmona
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  2. Andrew Silver
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  3. Ian P. Tomlinson
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Correspondence to Ian P. Tomlinson .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Surgical Oncology, The University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Miguel A. Rodriguez-Bigas

  2. Associate Professor of Surgery, Brazilian Registry of Inherited, Colorec, University of São Paulo Medical School, Sao Paulo, Brazil

    Raul Cutait

  3. M.D. Anderson Cancer Center, Gastroenterology, The University of Texas, Houston, 77030, Texas, USA

    Patrick M. Lynch

  4. Cancer Research UK London Research Insti, Molecular and Population Genetics Labora, London, United Kingdom

    Ian Tomlinson

  5. Medical Center, Gastroenterology, Leiden University, Leiden, 2333 AA, Netherlands

    Hans F.A. Vasen

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Carvajal-Carmona, L.G., Silver, A., Tomlinson, I.P. (2010). Molecular Genetics of Familial Adenomatous Polyposis. In: Rodriguez-Bigas, M., Cutait, R., Lynch, P., Tomlinson, I., Vasen, H. (eds) Hereditary Colorectal Cancer. M.D. Anderson Solid Tumor Oncology Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6603-2_3

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