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Molecular Genetics of Familial Adenomatous Polyposis

  • Luis G. Carvajal-Carmona
  • Andrew Silver
  • Ian P. TomlinsonEmail author
Chapter
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)

Abstract

With the advances in molecular genetics, the function of the APC gene has been and still is being described. In this chapter, a description of the APC protein, function, its relation to tumorigenesis, Familial Adenomatous Polyposis and other colorectal cancer syndromes will be discussed. Finally animal models which have been proven invaluable in the discovery of the APC protein function, will be described.

Keywords

Molecular Genetics Familial Adenomatous Wnt signalling 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Luis G. Carvajal-Carmona
  • Andrew Silver
  • Ian P. Tomlinson
    • 1
    Email author
  1. 1.Molecular and Population Genetics LaboratoryCancer Research UK London Research InstituteLondonUK

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