MUTYH-Associated Polyposis

  • N. Jones
  • M. Nielsen
  • S. Vogt
  • C. M. Tops
  • H. F. A. Vasen
  • F. J. Hes
  • S. Aretz
  • J. R. Sampson
Chapter
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)

Abstract

MUTYH-associated polyposis is an autosomal recessive syndrome predisposing to colorectal cancer. The syndrome was described in the last decade and is characterized by an inherited deficiency in base excision repair. The natural history of the syndrome is still being described. This chapter will address the advances made in MUTYH-associated polyposis.

Keywords

MAP MUTYH Base excision repair 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • N. Jones
    • 1
  • M. Nielsen
    • 2
  • S. Vogt
    • 3
  • C. M. Tops
    • 2
  • H. F. A. Vasen
    • 4
  • F. J. Hes
    • 2
  • S. Aretz
    • 3
  • J. R. Sampson
    • 1
  1. 1.Institute of Medical Genetics, School of MedicineHealth ParkCardiffUK
  2. 2.Department of Clinical GeneticsLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Institute of Human GeneticsUniversity of BonnBonnGermany
  4. 4.Department of Gastroenterology & Medical OncologyLeiden University Medical CenterLeidenThe Netherlands

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