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MUTYH-Associated Polyposis

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Hereditary Colorectal Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA,volume 5))

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Abstract

MUTYH-associated polyposis is an autosomal recessive syndrome predisposing to colorectal cancer. The syndrome was described in the last decade and is characterized by an inherited deficiency in base excision repair. The natural history of the syndrome is still being described. This chapter will address the advances made in MUTYH-associated polyposis.

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Author information

Authors and Affiliations

  1. Institute of Medical Genetics, School of Medicine, Health Park, Cardiff, CF14 4XN, UK

    N. Jones & J. R. Sampson

  2. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

    M. Nielsen, C. M. Tops & F. J. Hes

  3. Institute of Human Genetics, University of Bonn, Bonn, Germany

    S. Vogt & S. Aretz

  4. Department of Gastroenterology & Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands

    H. F. A. Vasen

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  1. N. Jones
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  2. M. Nielsen
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  3. S. Vogt
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  4. C. M. Tops
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  5. H. F. A. Vasen
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  6. F. J. Hes
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  7. S. Aretz
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  8. J. R. Sampson
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Correspondence to J. R. Sampson .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Surgical Oncology, The University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Miguel A. Rodriguez-Bigas

  2. Associate Professor of Surgery, Brazilian Registry of Inherited, Colorec, University of São Paulo Medical School, Sao Paulo, Brazil

    Raul Cutait

  3. M.D. Anderson Cancer Center, Gastroenterology, The University of Texas, Houston, 77030, Texas, USA

    Patrick M. Lynch

  4. Cancer Research UK London Research Insti, Molecular and Population Genetics Labora, London, United Kingdom

    Ian Tomlinson

  5. Medical Center, Gastroenterology, Leiden University, Leiden, 2333 AA, Netherlands

    Hans F.A. Vasen

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Jones, N. et al. (2010). MUTYH-Associated Polyposis. In: Rodriguez-Bigas, M., Cutait, R., Lynch, P., Tomlinson, I., Vasen, H. (eds) Hereditary Colorectal Cancer. M.D. Anderson Solid Tumor Oncology Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6603-2_19

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