In Lynch syndrome surveillance aims at prevention of early detection of cancer types observed to occur in significant excess. At present, regular prophylactic examinations have been shown beneficial for colorectal and endometrial cancer, i.e. repeated colonoscopy and endometrial biopsy combined with ultrasonograpy. For other less common cancer types involved, no proven benefit has been shown. The guidelines of identifying Lynch syndrome, the principles of genetic testing, and arranging surveillance are reviewed in this article, also shortly dealing with prophylactic surgery and possible chemoprevention in future.
KeywordsColonoscopy Colorectal carcinoma Endometrial carcinoma Lynch syndrome Cancer prevention Polypectomy Endometrial biopsy Prophylactic surgery
- 4.Wilson JMG, Junger G. Principles and practice of screening for disease. Public Health Papers 34. WHO, Geneva; 1968Google Scholar
- 28.Myrhoj T, Andersen M-B, Bernstein I. Screening for urinary tract cancer with urine cytology in HNPCC-families. Fam Cancer. 2007;6:346 (abstr).Google Scholar
- 33.Lu K, Loose D, Lynch H, et al. Preliminary analysis of a prospective, multi-center endometrial cancer chemoprevention study in women with Lynch syndrome. Fam Cancer. 2007;6:347 (abstr).Google Scholar