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Kernicterus pp 51-64 | Cite as

The Gunn Rat Model

  • David W. McCandless
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

In 1938, an important paper appeared in The Journal of Heredity, which described for the first time a genetic mutation in Wistar rats resulting in neonatal jaundice (Gunn, C. 1938). The significance of this can hardly be overstated, as nearly all features of this murine model of hyperbilirubinemia correlate exactly with those of the human disorder known as the Crigler–Najjar syndrome. This has permitted extensive and meaningful data to be derived from animal studies. Because of this, knowledge of hyperbilirubinemia has been advanced at a rapid rate. This chapter will detail with some of the pertinent findings from the Gunn rat model.

Keywords

Purkinje Cell Brain Mitochondrion Littermate Control Unconjugated Bilirubin Krebs Cycle Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology & AnatomyRosalind Franklin University of Medicine & Science, Chicago Medical SchoolNorth ChicagoUSA

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