Abstract
Numerous neurological sequelae result from exposure of the newborn infant to hyperbilirubinemia. These range from severe kernicterus and cerebral palsy to mild behavioral and/or intelligence quotient loss. Frequently, the findings in newborns exposed to high serum bilirubin levels depend in some measure on the sophistication of those examining the infants, or later, children who have recovered. Many manuscripts have been published describing studies aimed at elucidating the possible effects of bilirubin on neurodevelopment, with conflicting results.
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References
Day, R., and Haines, M. (1954) Intelligence quotients of children recovered from erythroblastosis fetalis since the introduction of exchange transfusion. Pediatr. 13:333–338
Hyman, C., et al. (1969) CNS abnormalities after neonatal hemolytic disease or hyperbilirubinemia. Am. J. Dis. Child. 117:395–405
Jangaard, K., et al. (2008) Outcomes in a population of healthy term and near term infants with serum bilirubin levels of 325 micromolar who were born in Nova Scotia, Canada, between 1994 and 2000. Pediatr. 122:119–124
Johnston, W., et al. (1967) Erythroblastosis fetalis and hyperbilirubinemia. Pediatrics, 39:88–92
McCandless, D. (2010a) Thiamine deficiency in mammals. In Thiamine deficiency and associated clinical disorders. McCandless, D. ed. Springer, New York, NY
Newman, T., and Klebanoff, M. (1993) Neonatal hyperbilirubinemia and longterm outcome: another look at the collaborative perinatal project. Pediatr. 92:651–657
Rubaltelli, F., et al. (1989) Tin-protoporphyrin in the management of children with Crigler-Najjar disease. Pediatr. 84:728–731
Scheidt, P., et al. (1991) Intelligence at 6 years in relation to neonatal bilirubin levell. Pediatr. 87:797–805
Seidman, D., et al. (1991) Neonatal hyperbilirubinemia and physical and cognitive performance at 17 years of age. Pediatr. 88:828–833
Wallerstein, H. (1946) Treatment of severe erythroblastosis by simultaneous removal and replacement of blood of newborn infant. Science 103:583–587
Watchko, J., and Maisels, M. (2003) Jaundice in low birth weight infants: pathobiology and outcome. Arch. Dis Child. 88:455–458
WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50
Holmes, G., et al. (1968) Neonatal bilirubinemia in production of long term deficits. Am. J. Dis. Child. 116:37–43
Shevell, M., Majnemer, A., and Schiff, D. (1998) Neurologic perspectives of Crigler-Najjar syndrome type 1. J. Child. Neurol. 13:265–269
Newman, T., Liljestrand, P., and Escobar, G. (2003) Infants with bilirubin levels of 30 mg/dl or more in a large managed care organization. Pediatr. 111:1303–1311
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McCandless, D.W. (2011). Neurological Sequelae from Jaundice. In: Kernicterus. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4419-6555-4_21
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DOI: https://doi.org/10.1007/978-1-4419-6555-4_21
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