Abstract
The occurrence of breast milk jaundice, or an exaggerated hyperbilirubinemia associated with breast milk, was first described by Arias and colleagues in 1963 (Arias, I., et al. 1963a, b, 1964a, b). The suggestion was made that the hyperbilirubinemia was a result of the presence of the steroid pregnane-3-20-diol in breast milk which acted to inhibit glucuronyl transferase, the bilirubin-conjugating enzyme.
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References
Gartner, L., and Herschel, M. (2001) Jaundice and breastfeeding. Pediatr. Clin. North Am. 48:389–399
Gourley, G. (2009) Breast-feeding, jaundice, and kernicterus. Semin. neonat. 7:135–141
Grunebaum, E., et al. (1991) Breast milk jaundice. Euro. J. Ped. 150:267–270
Hargreaves, T., and Piper, R. (1971) Breast milk jaundice. Arch. Dis. Child. 46:195–198
Huang, A., et al. (2009) Differential risk for early breastfeeding jaundice in a multi-ethnic Asian cohort. Ann. Acad. Med. Sing. 38:217–224
Maruo, Y., et al. (2000) Prolonged unconjugated hyperbilirubinemia associated with breast milk. Pediatr. 106:e59
Murphy, J., et al. (1981) Pregnanediols and breast milk jaundice. Arch. Dis. Child. 56:474–476
Onishi, S., et al. (1979) The separation of configurational isomers of bilirubin by high pressure liquid chromatography and the mechanism of jaundice phototherapy. Biochem. Biophys. Res. Comm. 90:890–896
Sirota, L., et al. (1988) Breast milk jaundice in preterm infants. Clin. Ped. 4:195–197
WHO Severe and complicated malaria: A report of the WHO malaria action programme. Trans. R. Soc. Med. Hyg. 80:1–50
Wong, Y., and Wood, B. (1971) Breast milk jaundice and oral contraceptives. BMJ 5:403–404
Gourley, G. (2000) Breastfeeding, diet, and neonatal hyperbilirubinemia. Pediatr. In review e25–e31
Arias, I., and Gartner, L. (1970) Breast milk jaundice. BMJ 4:177
Arias, I., et al. (1964a) Prolonged neonatal unconjugated hyperbilirubinemia associated with breasr feeding and a steroid that inhibits glucuronide formation. J. Clin. Invest. 43:2037–2047
Arias, I., et al. (1964b) Unconjugated hyperbilirubinemia. J. Vclin. Invest. 43:1249–1250
Arias, I., et al. (1963a) Effect of several drugs and chemicals on hepatic glucuronide formation in newborn rats. Proc. Soc. Exp. Biol. Med. 123:1037–1045
Arias, I., et al. (1963b) Proc of the 55th meeting of the Amer. Soc. Clin. Invest
Ramos, A., Silverberg, M., and Stern, L. (1966) Pregnanediol and neonatal hyperbilirubinemia. Amer. J. Dis. Child. 111:353–356
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McCandless, D.W. (2011). Breast Milk Jaundice. In: Kernicterus. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4419-6555-4_11
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DOI: https://doi.org/10.1007/978-1-4419-6555-4_11
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