Abstract
Because scleritis may occur in association with a variety of noninfectious local and systemic disorders (autoimmune, dermatological, metabolic, and foreign body reactions), its presence must be regarded in relation to the larger picture of a patient’s general health. Scleritis is frequently seen in association with autoimmune vasculitic diseases that affect predominantly small- and medium-sized vessels, such as rheumatoid arthritis, granulomatosis with polyangiitis (Wegener), relapsing polychondritis, arthritis and inflammatory bowel disease, systemic lupus erythematosus, polyarteritis nodosa, psoriatic arthritis, Behçet’s disease, or Cogan’s disease; scleritis is less commonly found in association with autoimmune vasculitic diseases that affect predominantly large-sized arteries, such as reactive arthritis, ankylosing spondylitis, or giant-cell arteritis. Scleritis may also be associated with other diseases, such as atopy, rosacea, gout, or local foreign body reactions.
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References
Harris ED. Rheumatoid arthritis: the clinical spectrum. In: Kelley WN, Harris ED, Ruddy S, Sledge CB, editors. Textbook of rheumatology. 3rd ed. Philadelphia: W.B. Saunders Company; 1989.
Fleming A, Benn RT, Corbett M, et al. Early rheumatoid disease. II. Patterns of joint involvement. Ann Rheum Dis. 1976;35:361.
Hull S, Mathews JA. Pulmonary necrobiotic nodules as a presenting feature of rheumatoid arthritis. Ann Rheum Dis. 1982;41:21.
Hurd ER. Extra-articular manifestations of rheumatoid arthritis. Semin Rheum Dis. 1979;8:151.
Hart FD. Rheumatoid arthritis. Extra-articular manifestations. Br Med J. 1969;3:131.
Nepom GT, Byers P, Seyfried C, et al. HLA genes associated with rheumatoid arthritis: identification of susceptibility alleles using specific oligonucleotide probes. Artritis Rheum. 1989;32:15.
Jacoby RK, Jayson MIV, Cosh JA. Onset, early stages and prognosis of rheumatoid arthritis: a clinical study of 100 patients with 11 year follow-up. Br Med J. 1973;2:96.
Fleming A, Crown JM, Corbett M. Early rheumatoid disease. I. Onset. Ann Rheum Dis. 1976;35:357.
Sharp JT, Calkins E, Cohen AS, et al. Observations on the clinical, chemical, and serologic manifestations of rheumatoid arthritis based on the course of 154 patients. Medicine. 1964;43:41.
Masi AT, Maldonado-Cocco JA, Kaplan SB, et al. Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum. 1976;5:299.
Talbott JH, Altman RD, Yu TF. Gouty arthritis masquerading as rheumatoid arthritis or viceversa. Semin Arthritis Rheum. 1978;8:77.
Khachadurian AK. Migratory polyarthritis in familial hypercholesterolemia (type II hyperlipoproteinemia). Arthritis Rheum. 1968;2:385.
Wiernik PH. Amyloid joint disease. Medicine (Baltimore). 1971;51:465.
Gordon DA, Pruzanski W, Ogyzlo MA, Little HA. Amyloid arhritis simulating rheumatoid disease in five patients with multiple myeloma. Am J Med. 1973;55:142.
Healey LA, Wilske KR, Sagebiel RW. Rheumatoid nodules simulating basal-cell carcinoma. N Engl J Med. 1967;277:7.
Wood MG, Beerman H. Necrobiosis lipoidica, granuloma anulare. Report of a case with lesions in the galea aponeurotica of a child. Am J Dis Child. 1958;96:720.
Hahn BH, Yardley JH, Stevens MB. “Rheumatoid” nodules in systemic lupus erythematosus. Ann Intern Med. 1970;72:49.
Dubois EL, Friou GJ, Chandor S. Rheumatoid nodules and rheumatoid granulomas in systemic lupus erythematosus. JAMA. 1972;220:515.
Barrow MV, Holubar K. Multicentric reticulohistiocytosis: a review of 33 patients. Medicine (Baltimore). 1969;48:287.
Cats A, Hazevoet HM. Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. Ann Rheum Dis. 1970;29:254.
Mongan ES, Cass RM, Jacox RF, Vaughan JH. A study of the relation of seronegative and seropositive rheumatoid arthritis to each other and to necrotizing vasculitis. Am J Med. 1969;47:23.
Turner R, Collins R, Nomeir AM. Extraarticular manifestations of rheumatoid arthritis. Bull Rheum Dis. 1978–1979;29:986.
Sokoloff L, Bunim JJ. Vascular lesions in rheumatoid arthritis. J Chron Dis. 1957;5:668.
Duthie JJR, Brown PE, Truelove LH, et al. Course and prognosis in rheumatoid arthritis. A further report. Ann Rheum Dis. 1964;23:193.
Ragan C, Farrington E. The clinical features of rheumatoid arthritis. JAMA. 1962;181:663.
Scott JT, Hourhane DO, Doyle FH, et al. Digital arteritis in rheumatoid disease. Ann Rheum Dis. 1961;20:224.
Schmid FR, Cooper NS, Ziff M, et al. Arteritis in rheumatoid arthritis. Am J Med. 1961;30:56.
Bienenstock H, Minick R, Rogoff B. Mesenteric arteritis and intestinal infarction in rheumatoid disease. Arch Intern Med. 1967;119:359.
Voyles WF, Searles RP, Bankhurst AD. Myocardial infarction caused by rheumatoid vasculitis. Arthritis Rheum. 1980;23(7):860.
Fong LP, Sainz de la Maza M, Rice BA, et al. Immunopathology of scleritis. Ophthalmology. 1991;98:472.
Scott DG, Bacon PA, Tribe CR. Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore). 1981;60(4):288.
Scott DGI, Bacon PA, Allen C, et al. IgG rheumatoid factor, complement, and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. Clin Exp Immunol. 1981;43:54.
Hunder GG, McDuffie FC. Hypocomplementinemia in rheumatoid arthritis. Am J Med. 1973;54:461.
Scott DG, Baron PA, Elliot PJ, et al. Systemic vasculitis in a district general hospital 1972–80. Quart J Med. 1982;51:292.
Ferguson RH, Slocumb CH. Peripheral neuropathy in rheumatoid arthritis. Bull Rheum Dis. 1961;11:251.
Walker WC, Wright V. Pulmonary lesions and rheumatoid arthritis. Medicine. 1968;47:501.
Dodson WH, Hollingsworth JW. Pleural effusion in rheumatoid arthritis: impaired transport of glucose. N Engl J Med. 1966;275:1337.
Jones SJ. An account of pleural effusions, pulmonary nodules and cavities in rheumatic disease. Br J Dis Chest. 1978;72:39.
Portner MM, Gracie WA. Rheumatoid lung disease with cavitary nodules, pneumothorax and eosinophilia. N Engl J Med. 1966;275:697.
Brannan HM, Good CA, Divertie MB, et al. Pulmonary disease associated with rheumatoid arthritis. J Am Med Assoc. 1964;189:914.
Dixon AS, Ball J. Honeycomb lung and chronic rheumatoid arthritis: a case report. Ann Rheum Dis. 1957;16:241.
Stack BHR, Grant IWB. Rheumatoid interstitial lung disease. Br J Dis Chest. 1965;59:202.
Walker WC, Wright V. Diffuse interstitial pulmonary fibrosis and rheumatoid arthritis. Ann Rheum Dis. 1969;28:252.
Frank ST, Weg JG, Harkleroad LE, et al. Pulmonary dysfunction in rheumatoid disease. Chest. 1973; 63:27.
Caplan A. Certain unusual radiographic appearances in the chest of coal miners suffering from RA. Thorax. 1953;8:29.
Caplan A, Cowen EDH, Gough J. Rheumatoid pneumoconiosis in a foundry worker. Thorax. 1958;13:181.
Chatgidakis CB, Theron C. Rheumatoid pneumoconiosis (Caplan’s syndrome): a discussion of the disease and a report of a case in a European Witwatersrand gold miner. Arch Environ Health. 1961;2:397.
Walker WC. Pulmonary infections and rheumatoid arthritis. Quart J Med. 1967;36:239.
Catheart ES, Spodick DH. Rheumatoid heart disease: a study of the incidence and nature of cardiac lesions in rheumatoid arthritis. JAMA. 1962;266:959.
Bongiglio T, Atwater EC. Heart disease in patients with seropositive rheumatoid arthritis: a controlled autopsy study and review. Arch Intern Med. 1969;124:714.
Cosh JA. Arthritis and the heart. Bristol Med Chir J. 1969;84:145.
Comess KA, Fenster PE, Gall EP. Cardiac involvement in rheumatoid arthritis. Cardiovasc Res. 1982;3:533.
Lie JT. Rheumatoid arthritis and heart disease. Primary Cardiol. 1982;40:137.
Kirk J, Cosh J. The pericarditis of rheumatoid arthritis. Quart J Med. 1969;38:397.
Bacon PA, Gibson DG. Cardiac involvement in rheumatoid arthritis – an echocardiographic study. Ann Rheum Dis. 1972;31:426.
MacDonald WJ, Crawford MH, Klippel JH, et al. Echocardiographic assessment of cardiac structure and function in patients with rheumatoid arthritis. Am J Med. 1977;63:890.
Butman S, Espinoza LR, DelCarpio J, et al. Rheumatoid pericarditis: rapid deterioration with evidence of local vasculitis. JAMA. 1977;238:2394.
Franco AE, Levine HO, Hall AP. Rheumatoid pericarditis: report of 17 cases diagnosed clinically. Ann Intern Med. 1972;77:837.
Khan AH, Spodick DH. Rheumatoid heart disease. Semin Arthritis Rheum. 1972;1:327.
Sokoloff L. The heart in rheumatoid arthritis. Am Heart J. 1953;45:635.
Leibowitz WB. The heart in rheumatoid arthritis. Ann Intern Med. 1963;58:102.
Harris M. Rheumatoid heart disease with complete heart block. J Clin Pathol. 1970;23:623.
Hoffman FG, Leight L. Complete atrioventricular block associated with rheumaoid disease. Am J Cardiol. 1965;16:585.
Roberts WC, Kehoe JA, Carpenter DF, et al. Cardiac valvular lesions in rheumatoid arthritis. Arch Intern Med. 1968;122:141.
Cruickshank B. Heart lesions in rheumatoid disease. J Pathol Bacteriol. 1958;76:223.
Goehrs HR, Baggenstoss AH, Slocumb CH. Cardiac lesions in rheumatoid arthritis. Arthritis Rheum. 1960;3:298.
Roberts WC, Dangel JC, Buklay BH. Non-rheumatic valvular cardiac disease: a clinicopathologic survey of 27 different conditions causing valvular dysfunction. Cardiovasc Clin. 1973;5:333.
Reimer KA, Rodgers RF, Oyasu R. Rheumatoid arthritis with rheumatoid heart disease and granulomatous aortitis. JAMA. 1976;235:2510.
Bywaters EGL. The relation between heart and joint disease including “rheumatoid heart disease” and chronic postrheumatic arthritis (type Jaccoud). Br Heart J. 1950;12:101.
Karten I. Arteritis, myocardial infarction and rheumatoid arthritis. JAMA. 1969;210:1717.
Parrillo JE, Fauci AS. Necrotizing vasculitis, coronary angiitis and the cardiologist. Am Heart J. 1980;99:547.
Sweezy RL. Myocardial infarction due to rheumatoid arteritis. JAMA. 1967;199:855.
Chamberlain MA, Bruckner FE. Rheumatoid neuropathy: clinical and electrophysiological features. Ann Rheum Dis. 1970;29:609.
Weller RO, Bruckner FE, Chamberlain MA. Rheumatoid neuropathy: a histological and electrophysiological study. J Neurol Neurosurg Psychiatry. 1970;33:592.
Irby R, Adams RA, Toone EC. Peripheral neuritis associated with rheumatoid arthritis. Arthritis Rheum. 1958;1:44.
Pallis CA, Scott JT. Peripheral neuropathy in rheumatoid arthritis. Br Med J. 1965;1:1141.
Motulsky AG, Weinberg S, Saphir O, et al. Lymph nodes in rheumatoid arthritis. Arch Intern Med. 1952;90:660.
Nosanshuk JS, Schnitzer B. Follicular hyperplasia in lymph ` nodes from patients with rheumatoid arthritis. Cancer. 1969;24:343.
Robertson MDJ, Hart FD, White WF, et al. Rheumatoid lymphadenopathy. Ann Rheum Dis. 1968;27:153.
Kassan SS, Hoover R, Kimberly RP. Increased incidence of malignancy in Sjögren’s syndrome. Arthritis Rheum. 1977;20:123.
Whaley K, Webb J, McAvoy BA, et al. Sjögren’s syndrome. 2. Clinical associations and immunological phenomena. Quart J Med. 1973;42:513.
Felty AR. Chronic arthritis in the adult, associated with splenomegaly and leucopenia. Johns Hopkins Hosp Bull. 1924;35:16.
Ruderman M, Miller LM, Pinals RS. Clinical and serologic observations on 27 patients with Felty’s syndrome. Arthritis Rheum. 1968;11:377.
Sienknecht CW, Urowitz MB, Pruzanski W, et al. Felty’s syndrome. Clinical and serological analysis of 34 cases. Ann Rheum Dis. 1977;36:500.
Hurd ER, Andreis M, Ziff M. Phagocytosis of immune complexes by polymorphonuclear leucocytes in patients with Felty’s syndrome. Clin Exp Immunol. 1977;28:413.
Joyce RA, Boggs DR, Chervenick PA, et al. Neutrophil kinetics in Felty’s syndrome. Am J Med. 1980;69:695.
Howe GB, Fordham JN, Brown KA, et al. Polymorphonuclear cell function in rheumatoid arthritis and in Felty’s syndrome. Ann Rheum Dis. 1981;40:370.
Gupta RC, Laforce FM, Mills DM. Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty’s syndrome. J Lab Clin Med. 1976;88:183.
Laszlo J, Jones R, Silberman HR, et al. Splenectomy for Felty’s syndrome: clinicopathological study of 27 patients. Arch Intern Med. 1978;138:597.
Goldberg J, Pinals RS. Felty’s syndrome. Semin Arthritis Rheum. 1980;10:52.
Cohen AS. Amyloidosis associated with rheumatoid arthritis. Med Clin North Am. 1968;52:643.
Husby G. Amyloidosis in rheumatoid arthritis. Ann Clin Res. 1975;7:154.
Arapakis G, Tribe CR. Amyloidosis in rheumatoid arthritis investigated by means of rectal biopsy. Ann Rheum Dis. 1963;22:256.
Trieger N, Cohen AS, Calkins E. Gingival biopsy as a diagnostic aid in amyloid disease. Arch Oral Biol. 1959;1:187.
Falcek HM, Törnroth T, Skrifvars B, et al. Resolution of renal amyloidosis secondary to rheumatoid arthritis. Acta Med Scand. 1979;205:651.
Fernandes L, Sullivan S, McFarlane IG, et al. Studies on the frequency and pathogenesis of liver involvement in rheumatoid arthritis. Ann Rheum Dis. 1979;38:501.
Weinblatt ME, Tesser JRP, Gilliam JH. The liver in rheumatic diseases. Semin Arthritis Rheum. 1981;11:399.
Mogadam M, Schuman B, Duncan H, et al. Necrotizing colitis associated with rheumatoid arthritis. Gastroenterology. 1969;57:168.
Pettersson T, Wegelius D, Skrifvars B. Gastrointestinal disturbances in patients with severe rheumatoid arthritis. Acta Med Scand. 1970;188:139.
Atwater EC, Morgan ES, Wieche DR, et al. Peptic ulcer and rheumatoid arthritis: a prospective study. Arch Intern Med. 1965;115:184.
Brun C, Olsen TX, Rasshou F, et al. Renal biopsy in rheumatoid arthritis. Nephron. 1965;2:65.
Healey LA, Bulger RJ. Abnormal renal function in rheumatoid arthritis. Arthritis Rheum. 1967;10:283.
Pollack VE, Priani CL, Steck IE, et al. The kidney in rheumatoid arthritis: studies by renal biopsy. Arthritis Rheum. 1962;5:1.
Lawson AAH, MacLean N. Renal disease and drug therapy in rheumatoid arthritis. Ann Rheum Dis. 1966;25:441.
Samuels B, Lee JC, Engleman EP, Hooper Jr J. Membranous nephropathy in patients with rheumatoid arthritis: relationship to gold therapy. Medicine. 1977;57:319.
O’Driscoll S, O’Driscoll M. Osteomalacia in rheumatoid arthritis. Ann Rheum Dis. 1980;39:1.
Williamson J. Incidence of eye disease in cases of connective tissue disease. Trans Ophthalmol Soc UK. 1974;94:742.
Thompson M, Eadie S. Keratoconjunctivitis sicca and rheumatoid arthritis. Ann Rheum Dis. 1956;5:21.
Lackington MC, Charlin VC, Gormas BA. Keratoconjunctivitis sicca y artritis reumatoidea. Rev Med Chil. 1951;79:133.
Lamberts DW. Dry eye and tear deficiency. Int Ophthalmol Clin. 1983;23(1):123.
Ichikawa Y, Takaya M, Saitoh H. Characterization of sicca symptoms in patients with Sjögren’s syndrome, and report of six cases lacking subjective sicca features (“subclinical syndrome”). Exp Clin Med. 1981;6:229.
von Grosz S. Aetiologie und therapy der Keratoconjunctivitis sicca. Klin Monatsbl Augenheilkund. 1936;97:472.
Sjögren H. Zur Kenntnis der Keratoconjunctivitis sicca (Keratitis filiformis bei Hypofunktion der Tränen drusen). Acta Ophthalmol. 1933;Suppl. 2:1.
McGavin DD, Williamson J, Forrester JV, et al. Episcleritis and scleritis: a study of their clinical manifestations and association with rheumatoid arthritis. Br J Ophthalmol. 1976;60:192.
Borel JF, Baumann G, Chapman I, et al. In vivo pharmacological effects of ciclosporin and some analogues. Adv Pharmacol. 1996;35:115–246.
Brignole F, Pisella PJ, De Saint Jean M, Goldschild M, Goguel A, Baudouin C. Flow cytometric analysis of inflammatory makers in KCS: 6-month treatment with topical cyclosporin A. Invest Ophthalmol Vis Sci. 2001;42:90–5.
Strong B, Farley W, Stern ME, Pflugfelder SC. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005;24:80–5.
Sall K, Stevenson OD, Mundorf TK, Reis BL. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology. 2000;107:631–9.
Kunert KS, Tisdale AS, Gipson IK. Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome dry eye with cyclosporine. Arch Ophthalmol. 2002;120:330–7.
Latkany R. Dry eyes: etiology and management. Curr Opin Ophthalmol. 2008;19:287–91.
Lyne AJ, Pitkeathley DA. Episcleritis and scleritis. Arch Ophthalmol. 1968;80:171.
Watson PG, Hayreh SS. Scleritis and episcleritis. Br J Ophthalmol. 1976;60:163.
Sainz de la Maza M, Jabbur NS, Foster CS. Severity of scleritis and episcleritis. Ophthalmology. 1994;101:389.
Tuft SJ, Watson PG. Progression of scleral disease. Ophthalmology. 1991;98:467.
Jayson MIV, Jones DEP. Scleritis and rheumatoid arthritis. Ann Rheum Dis. 1971;30:343.
Kleiner RC, Raber IM, Passero FC. Scleritis, pericarditis, and aortic insufficiency in a patient with rheumatoid arthritis. Ophthalmol.1984;91:941.
Sevel D. Rheumatoid nodule of the sclera. (A type of necrogranulomatous scleritis). Trans Ophthalmol Soc UK. 1965;85:357.
Sainz de la Maza M, Foster CS, Jabbur NS. Scleritis associated with rheumatoid artritis and with other systemic immune-mediated diseases. Ophthalmology. 1994;101:1281.
Foster CS, Forstot SL, Wilson LA. Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Ophthalmology. 1984;91:1253.
Smoleroff JW. Scleral disease in rheumatoid arthritis; report of three cases, in one of which both eyes were studied post mortem. Arch Ophthalmol. 1943;29:98.
Hurd ER, Snyder WB, Ziff M. Choroidal nodules and retinal detachments in rheumatoid arthritis. Am J Med. 1970;48:273.
Lachman SM, Hazleman BL, Watson PG. Scleritis and associated disease. Br Med J. 1978;1:88.
Brown SI, Grayson M. Marginal furrows: a characteristic corneal lesion of rheumatoid arthritis. Arch Ophthalmol. 1968;79:563.
Eiferman RA, Carothers DJ, Yankeelov JA. Peripheral rheumatoid ulceration and evidence for conjunctival collagenase production. Am J Ophthalmol. 1979;87:703.
Jayson MIV, Easty DL. Ulceration of the cornea in rheumatoid arthritis. Ann Rheum Dis. 1977;36:428.
Scharf Y, Meyer E, Nahir M, Zonis S. Marginal mottling of cornea in rheumatoid arthritis. Ann Ophthalmol. 1984;16:924.
Lyne AJ. “Contact lens” cornea in rheumatoid arthritis. Br J Ophthalmol. 1970;54:410.
Sainz de la Maza M, Foster CS. The diagnosis and treatment of peripheral ulcerative keratitis. Semin Ophthalmol. 1991;6(3):133.
Tauber J, Sainz de la Maza M, Hoang-Xuan T, Foster CS. An analysis of therapeutic decision making regarding immunosuppressive chemotherapy for peripheral ulcerative keratitis. Cornea. 1990;9(1):66.
Kimura SJ, Hogan MJ, O’Connor GR, et al. Uveitis and joint diseases. Arch Ophthalmol. 1967;77:309.
Meyer E, Scharf J, Miller B, et al. Fundus lesions in rheumatoid arthritis. Ann Ophthalmol. 1978; 10:1583.
Martin M, Scott D, Gilbert C, et al. Retinal vasculitis in rheumatoid arthritis. Br J Ophthalmol. 1981;282:1745.
Crompton J, Iyer P, Begg M. Vasculitis and ischemic optic neuropathy associated with rheumatoid arthritis. Aust J Ophthalmol. 1980;8:219.
Killian PJ, McClain B, Lawless OJ. Brown’s syndrome: an unusual manifestation of rheumatoid arthritis. Arthritis Rheum. 1977;20:1080.
Sandford-Smith JH. Intermittent superior oblique tendon sheath syndrome. Br J Ophthalmol. 1969;53:412.
Watson P, Fekete J, Deck J. Central nervous system vasculitis in rheumatoid arthritis. Can J Neurol Sci. 1977;4:269.
Ramos M, Mandybur TI. Cerebral vasculitis in rheumatoid arthritis. Arch Neurol. 1975;32:271.
Victor DI, Green WR, Stark WJ, et al. A non-permanent tonic pupil in rheumatoid arthritis. Can J Neurol Sci. 1977;4:209.
Edström G, Österlind G. A case of nodular rheumatic episcleritis. Acta Ophthalmol. 1948;26:1.
Mundy WL, Howard RY, Stillman PH, et al. Cortisone therapy in case of rheumatoid nodules of the eye in chronic rheumatoid arthritis. Arch Ophthalmol. 1951;45:531.
Fienberg R, Colpoys Jr FL. The involution of rheumatoid nodules treated with cortisone and of non-treated rheumatoid nodules. Am J Pathol. 1951;27:925.
Ferry AP. The histopathology of rheumatoid episcleral nodules: an extra-articular manifestation of rheumatoid arthritis. Arch Ophthalmol. 1969;82:77.
Leibowitz MA, Jakobiec FA, Donnenfeld ED, et al. Bilateral epibulbar rheumatoid nodulosis. A new ocular entity. Ophthalmology. 1988;95:1256.
Mesara BW, Brody GL, Oberman HA. “Pseudorheumatoid” subcutaneous nodules. Am J Clin Pathol. 1966;45:684.
Rao NA, Font RL. Pseudorheumatoid nodules of the ocular anexa. Am J Ophthalmol. 1975;79:471.
Ross MJ, Cohen KL, Peiffer Jr RL, et al. Episcleral and orbital pseudorheumatoid nodules. Arch Ophthalmol. 1983;101:418.
Rose HM, Ragan C, Pearce E, et al. Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis. Proc Soc Exp Biol Med. 1948;68:1.
Waaler E. On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles. Acta Pathol Microbiol Scand. 1940;17:172.
Tarkowski A, Czerkinsky C, Nilsson L-A. Simultaneous induction of rheumatoid factor-and antigen-specific antibody- secreting cells during the secondary immune response in man. Clin Exp Immunol. 1985;61:379.
Aho K, Palosuo T, Raunio V, et al. When does rheumatoid disease start? Arthritis Rheum. 1985;28:485.
Ball J, Lawrence JS. The relationship of rheumatoid serum factor to rheumatoid arthritis. Ann Rheum Dis. 1963;22:311.
Del Puente A, Knowler WC, Pettit DJ, et al. The incidence of rheumatoid arthritis is predicted by rheumatoid factor titer in a longitudinal population study. Arthritis Rheum. 1988;31:1239.
Bland JH, Brown EW. Seronegative and seropositive rheumatoid arthritis: clinical, radiological, and biochemical differences. Ann Intern Med. 1964; 60:88.
Kellgren JH, O’Brien WM. On the natural history of rheumatoid arthritis in relation to the sheep cell agglutination test (SCAT). Arthritis Rheum. 1962; 5:115.
Theofilopoulos AN, Burtonboy G, LoSpalluto JL, et al. IgM rheumatoid factor and low molecular weight IgM: an association with vasculitis. Arthritis Rheum. 1974;17:272.
Engstedt L, Strandberg O. Haematological data and clinical activity of the rheumatoid diseases. Acta Med Scand. 1966;180:13.
Samson D, Holliday D, Gumpel JM. Role of ineffective erythropoiesis in the anaemia of rheumatoid arthritis. Ann Rheum Dis. 1977;36:181.
Hutchinson RM, Davis P, Jayson MIV. Thrombocytosis in rheumatoid arthritis. Ann Rheum Dis. 1976;35:138.
Winchester RJ, Litwin SD, Koffler D, et al. Observations on the eosinophilia of certain patients with rheumatoid arthritis. Arthritis Rheum. 1971;14:650.
Panush RS, Franco AE, Schur PH. Rheumatoid arthritis associated with eosinophilia. Ann Intern Med. 1971;75:199.
Fleming A, Crown JM, Corbett M. Prognostic value of early features in rheumatoid disease. Br Med J. 1976;1:1243.
Amos RS, Constable TJ, Crockson RA, et al. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977;1:195.
Nusinow S, Arnold WJ. Prognostic value of C-reactive protein (CRP) levels in rheumatoid arthritis. Clin Res. 1982;30:474.
Roth SH. Remission: the goal of rheumatic disease therapy. J Rheumatol. 1982;9(8):120.
Ruddy S, Austen KF. Activation of the complement system in rheumatoid synovitis. Fed Proc. 1973; 32:134.
Jones VE, Jacoby RK, Wallington T, Holt P. Immune complexes in early arthritis. I. Detection of immune complexes before rheumatoid arthritis is definite. Clin Exp Immunol. 1981;44:512.
Zubler RH, Nydegger UE, Perrin LH, et al. Circulating and intraarticular immune complexes in patients with rheumatoid arthritis. J Clin Invest. 1976;57:1308.
Lessard J, Nunnery E, Cecere F, et al. Relationship between the articular manifestations of rheumatoid arthritis and circulating immune complexes detected by three methods and specific classes of rheumatoid factors. J Rheumatol. 1983;10:411.
Fessel WJ. SLE in the community: incidence, prevalence, outcome and first symptoms; the high prevalence in black women. Arch Intern Med. 1974;134:1027.
Siegel M, Lee SL. The epidemiology of systemic lupus erythematosus. Semin Arthritis Rheum. 1973;3:1.
Arnett FC, Shulman LE. Studies in familial systemic lupus erythematosus. Medicine. 1976;55:313.
Winchester RJ, Nunez-Roldon A. Some genetic aspects of systemic lupus erythematosus. Arthritis Rheum. 1982;25:833.
Hess EV. Introduction to drug related lupus. Kroc foundation conference on drug induced lupus. Arthritis Rheum. 1981;24:979.
Armas-Cruz R, Harnecker J, Ducach G, et al. Clinical diagnosis of systemic lupus erythematosus. Am J Med. 1958;25:409.
Davis P, Atkins B, Jesse RG, et al. Criteria for classification of SLE. Br Med J. 1973;3:88.
Labowitz R, Schumacher HR. Articular manifestations of systemic lupus erythematosus. Ann Intern Med. 1971;74:911.
Isbender DA, Snaith ML. Muscle disease in systemic lupus erythematosus: a study of its nature, frequency and cause. J Rheumatol. 1981;8:917.
Gilliam JN, Sontheimer OO. Skin manifestations of SLE. Clin Rheum Dis. 1982;8:207.
Ropes MW. Systemic lupus erythematosus. Harvard University Press: Cambridge; 1976.
Ellis SG, Verity MA. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955–1977. Sem Artritis Rheum. 1979;8:212.
Pirani CL, Pollack VE. Systemic lupus erythematosus glomerulonephritis. In: Andres GA, McCluskey RT, editors. Immunologically mediated renal disease: criteria for diagnosis. New York: Dekkar; 1978.
Chia GL, Mah EPK, Feng PH. Cardiovascular abnormalities in systemic lupus erythematosus. J Clin Ultrasound. 1981;9:237.
Bonfiglio TA, Botti RE, Hagstrom JWC. Coronary arteritis, occlusion and myocardial infarction due to lupus erythematosus. Am Heart J. 1972;83:153.
Homcy CJ, Liberthson RR, Fallon JT, et al. Ischemic heart disease in systemic lupus erythematosus: report of six cases. Am J Cardiol. 1982;49:478.
Libman E, Sacks B. A hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med. 1924;33:701.
Buckley BH, Roberts WC. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy: a study of 36 necropsy patients. Am J Med. 1975;58:243.
Feinglass EJ, Arnett FC, Dorsch CA, et al. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum and relationship to other features of the disease. Medicine. 1976;55:323.
Klippel JH, Zwaifler NJ. Neuropsychiatric abnormalities in systemic lupus erythematosus. Clin Rheum Dis. 1975;1:621.
Haupt HM, Moore GW, Hutchins GM. The lung in systemic lupus erythematosus: analysis of the pathologic changes in 120 patients. Am J Med. 1981;71:791.
Matthay RA, Schwartz MI, Petty TL, et al. Pulmonary manifestations of systemic lupus erythematosus: review of twelve cases of acute lupus pneumonitis. Medicine. 1974;54:397.
Runyon BA, LaBrecque DR, Anuras S. The spectrum of liver disease in systemic lupus erythematosus: report of 33 histologically proved cases and review of the literature. Am J Med. 1980;69:187.
Dillon AM, Stein HB, English RA. Splenic atrophy in SLE. Ann Intern Med. 1982;96:40.
Davies JB, Rao PK. Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmolo. 2008;19:512.
Watson PG, Hazleman BL. The sclera and systemic disorders. W.B. Saunders Company: Philadelphia; 1976. p. 206–305.
Cappaert WE, Purnell EW, Frank KE. Use of B-sector scan ultrasound in the diagnosis of benign choroidal folds. Am J Ophthalmol. 1977;84:375.
Gold DH, Morris DA, Henkind P. Ocular findings in systemic lupus erythematosus. Br J Ophthalmol. 1972;56:800.
Larson DL. Systemic lupus erythematosus. Little Brown: Boston; 1961.
Harvey AM, Shulman LE, Tumulty PA, et al. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine. 1954;33:291.
Frith P, Burge SM, Millard PR, et al. External ocular findings in lupus erythematosus: a clinical and immunopathological study. Br J Ophthalmol. 1990;74:163.
Reeves JA. Keratopathy associated with systemic lupus erythematosus. Arch Ophthalmol. 1965;74:159.
Henkind P, Gold DH. Ocular manifestations of rheumatic disorders: natural and iatrogenic. Rheumatology. 1973;4:13.
Halmay O, Ludwig K. Bilateral bandshaped deep keratitis and iridocyclitis in systemic lupus erythematosus. Br J Ophthalmol. 1964;48:558.
Spaeth GL. Corneal staining in systemic lupus erythematosus. N Engl J Med. 1967;276:1168.
Heaton JM. Sjögren’s syndrome and systemic lupus erythematosus. Br Med J. 1959;1:466.
Bencze G, Lakatos L. Relationship of systemic lupus erythematosus to rheumatoid arthritis, discoid lupus erythematosus, and Sjögren’s syndrome. Ann Rheum Dis. 1963;22:273.
Dubois EL. The clinical picture of systemic lupus erythematosus. In: Dubois EL, editor. lupus erythematosus. New York: McGraw-Hill Book Co; 1966. p. 129–276.
Steinberg AD, Talal N. The coexistence of Sjögren’s syndrome and systemic lupus erythematosus. Ann Int Med. 1971;74:55.
Brihaye-Van Geertruyden M, Danis P, Toussaint C. Fundus lesions with disseminated lupus. Arch Ophthalmol. 1954;51:799.
Maumenee AE. Retinal lesions in lupus erythematosus. Am J Ophthalmol. 1940;23:971.
Clifton F, Greer CH. Ocular changes in acute systemic lupus erythematosus. Br J Ophthalmol. 1955;39:1.
Rothfield N. Clinical features of systemic lupus erythematosus. In: Kelley WN, Harris ED, Ruddy S, Sledge CB, editors. Textbook of rheumatology. Philadelphia: WB Saunders Company; 1985. p. 1070–97.
Regan CDJ, Foster CS. Retinal vascular diseases: clinical presentation and diagnosis. Int Ophthalmol Clin. 1985;26:25.
Silberberg DH, Laties AM. Increased intracranial pressure in disseminated lupus erythematosus. Arch Neurol. 1973;29:88.
Raptk L, Menard HA. Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus. J Clin Invest. 1980;66:1391.
Weinstein A, Bordwell B, Stone B, et al. Antibodies to native DNA and serum complement (C3) levels: applications to the diagnosis of systemic lupus erythematosus. Am J Med. 1983;74:206.
Arnett FC. Seronegative spondylarthropathies. Bull Rheum Dis. 1987;37(1):1.
Marks SH, Barnett M, Calin A. Ankylosing spondylitis in women and men: a case–control study. J Rheumatol. 1983;10:624.
Woodrow JC. Genetic aspects of spondylarthropaties. Clin Rheum Dis. 1985;11:1.
Brewerton DA, Caffrey M, Hart FD, et al. Ankylosing spondylitis and HL-A 27. Lancet. 1973;1:904.
Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361.
Hunter T, Dubo H. Spinal fractures complicating ankylosing spondylitis. Ann Intern Med. 1978;88:546.
Khan MA. Ankylosing spondylitis. In: Calin A, editor. Spondyloarthropathies. Orlando, FL: Grune & Stratton; 1984. p. 69–117.
Bergfeldt L, Moller E. Complete heart block-another HLA-B27 associated disease manifestation. Tissue Antigens. 1983;21:385.
Bergfeldt L. HLA-B27 associated rheumatic diseases with severe cardiac bradyarrhythmias: clinical features and prevalence in 223 men with permanent pacemaker. Am J Med. 1983;75:210.
Khan MA, Kushner I. Ankylosing spondylitis and multiple sclerosis: a possible association. Arthritis Rheum. 1979;22:784.
Mason RM, Murray RS, Oates JK, et al. Prostatitis and ankylosing spondylitis. Rheum Phys Med. 1971;1:78.
Calin A. Renal glomerular function in ankylosing spondylitis. Scand J Rheumatol. 1975;4:241.
Pasternack A, Tornroth T, Martio J. Ultrastructural studies of renal arteriolar changes in ankylosing spondylitis. Acta Pathol Microbiol Scand Sect A. 1971;79:591.
Jayson MIV, Salmon PR, Harrison W. Amyloidosis in ankylosing spondylitis. Rheum Phys Med. 1971;1:78.
Jennette JC, Ferguson AL, Moore MA, et al. IgA nephropathy associated with seronegative spondylarthropathies. Arthritis Rheum. 1982;25:144.
Bluestone R. Ankylosing spondylitis. In: McCarthy DJ, editor. Arthritis and allied conditions. 10th ed. Philadelphia: Lea & Febiger; 1985. p. 819–40.
Hakin KN, Watson PG. Systemic associations of scleritis. In: Gold DH, editor. Systemic associations of ocular disorders. Int Ophthalmol Clin. 1991;31(3):111. Boston, Little: Brown and Company; 1991.
Rosenbaum JT, Theofilopoulos A, McDevitt HO, et al. Presence of circulating immune complexes in Reiter’s syndrome and ankylosing spondylitis. Clin Immun Pathol. 1981;18:291.
Keat AC. Reiter’s syndrome and reactive arthritis in perspective. N Engl J Med. 1983;309:1606.
Moller G. Immunology of reactive arthritis and ankylosing spondylitis. Immunol Rev. 1985;86:1.
Reiter H. Ueber eine bisher unerkannte spirochaeteninfektion (spirochaetosis arthritica). Deut Med Wschr. 1916;42:1435.
Aho K, Leirisalo-Repo M, Reop H. Reactive arthritis. In: Panayi GS, editor. Seronegative spondyloarthropathies, vol. 11. London: Saunders; 1985. p. 25–40.
Winchester R, Bernstein DH, Fisher HD, et al. The co-occurrence of Reiter’s syndrome and acquired immunodeficiency. Ann Intern Med. 1987;106:19.
Duvic M, Johnson TM, Rapini RP, et al. Acquired immunodeficiency syndrome-associated psoriasis and Reiter’s syndrome. Arch Dermatol. 1987;123:1622.
Lin RY. Reiter’s syndrome and human immunodeficiency virus infection. Dermatologica. 1988;176:39.
Carr JL, Friedman M. Keratodermia blennorrhagicum, report of a case with autopsy. Am J Pathol. 1944;20:709.
Calin A. Spondyloarthropathies. Orlando, Fl: Grune & Stratton; 1984.
Buskila D, Langevitz P, Tenenbaum J, et al. Malar rash in a patient with Reiter’s syndrome – a clue for the diagnosis of human immunodeficiency virus infection. J Rheumatol. 1990;17:843.
Lee DA, Barker SM, Daniel Su WP, et al. The clinical diagnosis of Reiter’s syndrome. Ophthalmology. 1986;93:350.
Ostler HB, Dawson CR, Schachter J, et al. Reiter’s syndrome. Am J Ophthalmol. 1971;71:986.
Weinberger HW, Ropes MW, Kulka JP, et al. Reiter’s syndrome, clinical and pathological observations: a lon-term study of 16 cases. Medicine. 1962;41:35.
Zewi M. Morbus Reiteri. Acta Ophthalmol. 1947;25:47.
Mattson R. Recurrent retinitis in Reiter’s disease. Acta Ophthalmol. 1955;33:403.
Gerber LH, Espinoza LR. Psoriatic arthritis. Orlando, FL: Grune & Stratton; 1985.
Suarez-Almazor ME, Rusell AS. Sacroiliitis in psoriasis: relationship to peripheral arthritis and HLA-B27. J Rheumatol. 1990;17:804.
Bennet RM. Psoriatic arthritis. In: McCarthy DJ, editor. Arthritis and allied conditions. 11th ed. Philadelphia: Lea and Febiger; 1989. p. 954–71.
Gladman DD, Stafford-Brady F, Chang C, et al. Longitudinal study of clinical and radiological progression in psoriatic arthritis. J Rheumatol. 1990; 17:809.
Leczinsky CG. The incidence of arthropathy in a ten-year series of psoriasis cases. Acta Derm Venereol. 1948;28:483.
Little M, Harvie JN, Lester RS. Psoriatic arthritis in severe psoriasis. Can Med Assoc J. 1975;112:317.
Roberts MET, Wright V, Hill AGS, et al. Psoriatic arthritis: a follow-up study. Ann Rheum Dis. 1976;35:206.
Lambert JR, Wright V. Eye inflammation in psoriatic arthritis. Ann Rheum Dis. 1976;35:354.
Bird HA, Wright V. Psoriatic arthritis. Clin Rheum Dis. 1983;9:671.
Palumbo PJ, Ward LE, Sauer WG. Musculoskeletal manifestations of inflammatory bowel disease: ulcerative and granulomatous colitis and ulcerative proctitis. Mayo Clin Proc. 1973;48:411.
Hopkins DJ, Horan E, Burton IL, et al. Ocular disorders in a series of 332 patients with Crohn’s disease. Br J Ophthalmol. 1974;58:732.
Wright R, Lumsden K, Luntz MH, et al. Abnormalities of the sacroiliac joints and uveitis in ulcerative colitis. Quart J Med. 1965;34:229.
Ernst BB, Lowder CY, Meisler D, et al. Posterior segment manifestations of inflammatory bowel disease. Ophthalmology. 1991;98:1272.
Knox DL, Schachat AP, Mustonen E. Primary, secondary and coincidental ocular complications of Crohn’s disease. Ophthalmology. 1984;91:163.
Yilmaz AE, Maden A, Unsal B. The prevalence of ocular involvement in patients with inflammatory bowel disease. Int J Colorectal Dis. 2007;22:1027.
Salmon JF, Wright JP, Murray ADN. Ocular inflammation in Crohn’s disease. Ophthalmology. 1991;98:480.
Mintz R, Feller ER, Bahr RL, Shah SA. Ocular manifestations of inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:135.
Petrelli EA, McKinley M, Troncale FJ. Ocular manifestations of inflammatory bowel disease. Ann Ophthalmol. 1982;14:356.
Jameson Evans P, Eustace P. Scleromalacia perforans associated with Crohn’s disease. Br J Ophthalmol. 1973;57:330.
Knox DL, Snip RC, Stark WJ. The keratopathy of Crohn’s disease. Am J Ophthalmol. 1980;90:862.
Clark RL, Muhletaler CA, Margulies SI. Colitic arthritis: clinical and radiographic manifestations. Radiol. 1971;101:585.
Jaksch-Wartenhorst R. Polychondropathia. Wien Arch Inn Med. 1923;6:93.
White JW. Relapsing polychondritis. Southern Med J. 1985;78:448.
Isaak BL, Liesengang TJ, Michet Jr CJ. Ocular and systemic findings in relapsing polychondritis. Ophthalmology. 1986;93:681.
Espinoza LR, Richman A, Bocanegra T, et al. Immune complex- mediated renal involvement in relapsing polychondritis. Am J Med. 1981;71:181.
Sundaram MBM, Raiput AH. Nervous system complications of relapsing polychondritis. Neurology. 1983;33:513.
Margargal LE, Donoso LA, Goldberg RE, et al. Ocular manifestations of relapsing polychondritis. Retina. 1981;1:96.
McKay DAR, Watson PG, Lyne AJ. Relapsing polychondritis and eye disease. Br J Ophthalmol. 1974;58:600.
Matoba A, Plager S, Barger J, et al. Keratitis in relapsing polychondritis. Ann Ophthalmol. 1984;16:367.
Chow MT, Anderson SF. Relapsing polychondritis. Optom Vis Sci. 2000;77:286.
Michelson JB. Melting corneas with collapsing nose. Surv Ophthalmol. 1984;29:148.
Hoangh-Xuan T, Foster CS, Rice BA. Scleritis in relapsing polychondritis. Response to therapy. Ophthalmology. 1990;97:892.
McAdam LP, O’Hanlan MA, Bluestone R, et al. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine. 1976;55:193.
Damiani JM, Levine HL. Relapsing polychondritis-report of ten cases. Laryngoscope. 1979;89:929.
Kussmaul A, Maier K. Über eine bischer nicht beschreibene eigenthümliche Arterienerkrankung (periarteritis nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Müskellähmung einhergeht. Dtsch Arch Klin Med. 1866;1:484.
Zeek PM. Periarteritis nodosa and other forms of necrotizing angiitis. N Engl J Med. 1953;18:764.
Lieb ES, Restivo C, Paulus HE. Immunosuppressive and corticosteroid therapy for polyarteritis nodosa. Am J Med. 1979;67:941.
Kurland LT, Chuang TY, Hunder GG. The epidemiology of systemic arteritis. In: Laurence RE, Shulman LE, editors. Current topics in rheumatology: epidemiology of the rheumatic diseases. New York: Gower Medical Publisher, Ltd; 1984. p. 196–205.
Cupps TR, Fauci AS. The vasculitides. Philadelphia: W.B. Saunders Company; 1981.
Cohen RD, Conn DL, Ilstrup DM. Clinical features, prognosis, and response to treatment in polyarteritis. Mayo Clin Proc. 1980;55:146.
Goldstein I, Wexler D. The ocular pathology of periarteritis nodosa. Arch Ophthalmol. 1929;2:288.
Friedenwald JS, Rones B. Ocular lesions in septicemia. Arch Ophthalmol. 1931;5:175.
Gaynon IE, Asbury MK. Ocular findings in a case of periarteritis nodosa. Am J Ophthalmol. 1943; 23:1072.
Goldsmith J. Periarteritis nodosa with involvement of the choroidal and retinal arteries. Am J Ophthalmol. 1946;29:435.
Goar EL, Smith LS. Polyarteritis nodosa of the eye. Am J Ophthalmol. 1952;35:1619.
Sheehan B, Harriman DG, Bradshaw JP. Polyarteritis nodosa with ophthalmic and neurological complications. Arch Ophthalmol. 1958;60:537.
King RT. Ocular involvement in a case of periarteritis nodosa. Trans Ophthalmol Soc UK. 1935;55:246.
Ford RG, Siekert RG. Central nervous system manifestations of periarteritis nodosa. Neurology. 1965; 15:114.
Kimbrell Jr OC, Wheliss JA. Polyarteritis nodosa complicated by bilateral optic neuropathy. JAMA. 1967;201:61.
Van Wien S, Merz EH. Exophthalmos secondary to periarteritis nodosa. Am J Ophthalmol. 1963;56:204.
Purcell Jr JJ, Birkenkamp R, Tsai CC. Conjunctival lesions in periarteritis nodosa, a clinical and immunopathologic study. Arch Ophthalmol. 1984;102:736.
Harbert F, McPherson SD. Scleral necrosis in periarteritis nodosa. Am J Ophthalmol. 1947;30:727.
Wise GN. Ocular periarteritis nodosa. AMA Arch Ophthalmol. 1952;48:1.
Cogan DG. Corneoscleral lesions in periarteritis nodosa and Wegener’s granulomatosis. Trans Am Acad Ophthalmol. 1955;53:321.
Moore JG, Sevel D. Corneoscleral ulceration in periarteritis nodosa. Br J Ophthalmol. 1966;50:651.
Longstreth PL, Lorobkin M, Palubinskas AJ. Renal microaneurysms in a patient with systemic lupus erythematosus. Radiology. 1974;113:65.
McKusick VA. Buerger’s disease: a distinct clinical and pathologic entity. JAMA. 1962;181:93.
Diaz-Perez JL, Winkelmann RK. Cutaneous periarteritis nodosa. Arch Dermatol. 1974;110:407.
Sack M, Cassidy JT, Bole GG. Prognostic factors in polyarteritis. J Rheumatol. 1975;2:411.
Dyck PJ, Conn DL, Okazaki H. Necrotizing angiopathic neuropathy: three-dimensional morphology of fiber degeneration related to sites of occluded vessels. Mayo Clin Proc. 1972;47:461.
Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951;27:277.
Chumbley LC, Harrison Jr EG, Deremee RA. Allergic granulomatosis and angiitis (Churg–Strauss syndrome). Report and analysis of 30 cases. Mayo Clin Proc. 1977;52:477.
Lanham JG, Elkon KB, Pusey CD, et al. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg- Strauss syndrome. Medicine (Baltimore). 1984;63:65.
Nissim F, Von der Valde J, Czernobilsky B. A limited form of Churg–Strauss syndrome. Arch Pathol Lab Med. 1982;106:305.
Cury D, Breakey AS, Payne BF. Allergic granulomatous angiitis associated with uveoscleritis and papilledema. Arch Ophthalmol. 1950;55:261.
Dicken CH, Winkelmann RK. The Churg–Strauss granuloma: cutaneous, necrotizing, palisading granuloma in vasculitis syndromes. Arch Pathol Lab Med. 1978;102:576.
Strauss L, Churg J, Zak FG. Cutaneous lesions of allergic granulomatosis. A histopathologic study. J Invest Dermatol. 1951;17:349.
Crotty CP, Deremee RA, Winkelmann RK. Cutaneous clinico-pathologic correlation of allergic granulomatosis. J Am Acad Dermatol. 1981;5:571.
Wegener F. Über generalisierte, septische Gefässerkrankungen. Verh Dtsch Ges Pathol. 1936;29:202.
Wegener F. Über eine eigenartige rhinogene granulomatose mit besonderer Beteilingung des Arteriensystems und der Nieren. Beitr Pathol Anat Allg Pathol. 1939;102:36.
Godman GC, Churg J. Wegener’s granulomatosis: pathology and review of the literature. Arch Pathol. 1954;58:533.
Walton EW. Giant cell granuloma of the respiratory tract (Wegener’s granulomatosis). Br Med J. 1958; 2:265.
Carrington CB, Leibow AA. Limited forms of angiitis and granulomatosis of Wegener’s type. Am J Med. 1966;41:497.
Gross WL. Wegener’s granulomatosis. New aspects of the disease course, immunodiagnostic procedures, and stage-adapted treatment. Sarcoidosis. 1989; 6:15.
Coutu RE, Klein M, Lessell S, et al. Limited form of Wegener granulomatosis. Eye involvement as a major sign. JAMA. 1975;233:868.
Spalton DJ, Graham EM, Page NGR, Sanders MD. Ocular changes in limited forms of Wegener’s granulomatosis. Br J Ophthalmol. 1981;65:553.
McDonald TJ, DeRemee RA. Wegener’s granulomatosis. Laryngoscope. 1983;93:220.
DeRemee RA, McDonald TJ, Harrison EG, et al. Wegener’s granulomatosis. Anatomic correlates, a proposed classification. Mayo Clin Proc. 1976;51:777.
Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener’s granulomatosis: prospective clinical and therapeutic experience with 85 patients over 21 years. Ann Intern Med. 1983;98:76.
Soukasian SH, Jakobiek FA, Niles JL, Pavan-Langston D. Trimethoprim-Sulfamethoxazole for scleritis associated with limited Wegener´s granulomatosis: use of histopathology and anti-neutrophil cytoplasmic antibody (ANCA) test. Cornea. 1993;12:174.
Hall SL, Miller LC, Duggan E, et al. Wegener’s granulomatosis in pediatric patients. J Pediatr. 1985; 106:739.
Nölle B, Specks U, Lüdemann J, et al. Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener’s granulomatosis. Ann Intern Med. 1989;111:28.
Pinching AJ, Lockwood CM, Pussell BA, et al. Wegener’s granulomatosis: observations on 18 patients with severe renal disease. Q J Med. 1983;52:435.
Bullen CL, Liesegang TJ, McDonald TJ, DeRemee RA. Ocular complications of Wegener’s granulomatosis. Ophthalmology. 1983;90:279.
Haynes BF, Fishman ML, Fauci AS, Wolff SM. The ocular manifestations of Wegener’s granulomatosis. Fifteen years experience and review of the literature. Am J Med. 1977;63:131.
Tarabishy AB, Schulte M, Papaliodis GN, Hoffman GS. Wegener’s granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease. Surv Ophthalmol. 2010;10:429.
Kinyoun JL, Kalina RE, Klein ML. Choroidal involvement in systemic necrotizing vasculitis. Arch Ophthalmol. 1987;105:939.
Schmidt R, Koderisch J, Krastel H, et al. Sicca syndrome in patients with Wegener’s granulomatosis. Lancet. 1989;1:904.
Leveille AS, Morse PH. Combined detachments in Wegener’s granulomatosis. Br J Ophthalmol. 1981;65:564.
Brubacker R, Font RL, Shepherd EM. Granulomatous sclerouveitis. Regression of ocular lesions with cyclophosphamide and prednisone. Arch Ophthalmol. 1971;86:517.
Sacks RD, Stock EL, Crawford SE, et al. Scleritis and Wegener’s granulomatosis in children. Am J Ophthalmol. 1991;111:430.
Kalina PH, Garrity JA, Herman DC, et al. Role of testing for anticytoplasmic autoantibodies in the differential diagnosis of scleritis and orbital pseudotumor. Mayo Clin Proc. 1990;65:1110.
Charles SJ, Meyer PAR, Watson PG. Diagnosis and management of systemic Wegener’s granulomatosis presenting with anterior ocular inflammatory disease. Br J Ophthalmol. 1991;75:201.
van der Woude FJ, Rasmussen N, Lobatto S, et al. Autoantibodies against neutrophils and monocytes; tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet. 1985;1:425.
Ludemann G, Gross WL. Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener’s granulomatosis. Clin Exp Immunol. 1987;69:350.
Savage CS, Winearls CG, Jones S, et al. Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet. 1987;1:1389.
Falk RJ, Jennette JC. Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Eng J Med. 1988;318:1651.
Niles JL, McCluskey RT, Ahmad MF, et al. Wegener’s granulomatosis autoantigen is a novel neutrophil serine protease. Blood. 1989;74:1888.
Jennette JC, Wilkman AS, Falk RJ. Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol. 1989;135:921.
Cohen Tervaert JW, Goldschmeding R, Elema JD, et al. Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum. 1990;33:1264.
Cohen Tervaert JW, Elema JD, Kallenberg CGM. Clinical and histopathological association of 29kD-ANCA and MPO-ANCA. APMIS. 1990;98(19):35.
Pulido JS, Goeken JA, Nerad JA, et al. Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies. Arch Ophthalmol. 1990;108:845.
Soukiasian SH, Foster CS, Niles JL, Raizman MB. Diagnostic value of anti-neutrophil cytoplasmic antibodies (ANCA) in scleritis associated with Wegener’s granulomatosis. Ophthalmology. 1992;99:125.
Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of WG. Arthritis Rheum. 1990;33:1101.
Feigenbaum A. Description of Behçet’s syndrome in the hippocratic third book of endemic diseases. Br J Ophthalmol. 1956;40:355.
Adamantiades B. Ann Ocul Paris. 1946;179:143.
Behçet H. Ueber rezidivieerende, aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge and an den Genitalien. Dermatol Wochenschr. 1937;105:1152.
Yamamoto S, Toyokawa H, Matsubara J, et al. A nation-wide survey of Behçet disease in Japan: 1. Epidemiological survey. Jpn J Ophthalmol. 1974; 18:282.
Foster CS, Baer JC, Raizman MB. Therapeutic responses to systemic immunosuppressive chemotherapy agents in patients with Behçet’s syndrome affecting the eyes. Rochester MN: Proc of the Fifth International Congress on Behçet’s Disease; 1989.
Atmaca LS. Fundus changes associated with Behçet’s disease. Graefe’s Arch Clin Exp Ophthalmol. 1989;227:340.
BenEzra D, Cohen E. Treatment and visual prognosis in Behçet’s disease. Brit J Ophthalmol. 1986;70:589.
Mishima S, Masuda K, Izawa Y, et al. Behçet’s disease in Japan: ophthalmological aspects. Trans Am Ophthalmol Soc. 1979;77:225.
Colvard DM, Robertson DM, O’Duffy JD. The ocular manifestations of Behçet’s disease. Arch Ophthalmol. 1977;95:1813.
Yazici H, Chamberlain MA, Schreuder I, et al. HLA antigens in Behçet’s disease: a reappraisal by a comparative study of Turkish and British patients. Ann Rheum Dis. 1980;39:344.
O’Duffy JD, Taswell HF, Elvebeck LR. HL-A antigens in Behçet’s disease. J Rheumatol. 1976;3:1.
Ohno S, Ohguchi M, Hirose S, et al. Close association of HLA- Bw51 with Behçet’s disease. Arch Ophthalmol. 1982;100:1455.
Baricordi OR, Sensi A, Pivetti-Pezzi P, et al. Behçet’s disease associated with HLA-B51 and DRw52 antigens in italians. Hum Immunol. 1986;17:297.
Davies PG, Fordham JN, Kirwan JR, et al. The pathergy test and Behçet’s syndrome in Britain. Ann Rheum Dis. 1984;43:70.
James DG, Spiteri MA. Behçet’s disease. Ophthalmology. 1982;89:1279.
O’Duffy JD. Suggested criteria for the diagnosis of Behçet’s disease. J Rheumatol. 1974;1(1):18.
Wechsler B, Davatchi F, Mizushima Y, (International Study Group for Behçet’s disease), et al. Criteria for diagnosis of Behçet’s disease. Lancet. 1990;335:1078.
Wilkinson IMS, Russell RWR. Arteries of the head and neck in giant cell arteritis. Arch Neurol. 1972; 27:378.
Klein RG, Hunder GG, Stanson AW, et al. Large artery involvement in giant cell (temporal) arteritis. Ann Intern Med. 1975;83:806.
Hunder GG, Bloch DA, Michel BA, et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum. 1990;33:8.
Paraskevas KT, Boumpas DT, Vrentzos GE, Mikhailidis DP. Oral and ocular/orbital manifestations of temporal arteritis: a disease with deceptive clinical symptoms and devastating consequences. Clin Rheumatol. 2007;26:1044.
Friedman G, Friedman B, Benbassat J. Epidemiology of temporal arteritis in Israel. Isr J Med Sci. 1982;18:241.
Machado EBV, Michet C, Ballard DJ, et al. Trends in incidence and clinical presentation of temporal arteritis in Olmsted County, Minnesota, 1950–1985. Athritis Rheum. 1988;31:745.
Hazleman B, Goldstone A, Voak D. Association of polymyalgia rheumatica and giant-cell arteritis with HLA-B8. Br Med J. 1977;2:989.
Barrier J, Bignon JD, Soulillou JP, et al. Increase prevalence of HLA-DR4 in giant-cell arteritis (letter). NEJM. 1981;305:104.
Malmvall B, Bentsson B, Rydberg L. HLA antigens in patients with giant cell arteritis, compared with two control groups of different ages. Scand J Rheumatol. 1980;9:65.
Hunder GG, Taswell HF, Pineda AA, et al. HLA antigens in patients with giant cell arteritis and polymyalgia rheumatica. J Rheumatol. 1977;4:321.
Huston KA, Hunder GG, Lie JT, et al. Temporal arteritis. A 25-year epidemiologic, clinical, and pathologic study. Ann Intern Med. 1978;89:162.
Whitfield AGW, Bateman M, Trevor-Cooke W. Temporal arteritis. Br J Ophthalmol. 1963;47:555.
Hunder GG. Giant cell (temporal) arteritis. Rheum Dis Clin N Am. 1990;16:399.
Caselli RJ, Hunder GG, Whisnant JP. Neurologic disease in biopsy-proven giant cell (temporal) arteritis. Neurology. 1988;38:352.
Reich KA, Giansiracusa DF, Strongwater SL. Neurologic manifestations of giant cell arteritis. Am J Med. 1990;89:67.
Cohen MD, Ginsburg WW. Polymyalgia rheumatica. Rheum Dis Clin of N Am. 1990;16:325.
Hunder GG, Allen GL. Giant cell arteritis: a review. Bull Rheum Dis. 1978–79;29:980.
Chuang T, Hunder GG, Ilstrup DM, et al. Polymyalgia rheumatica. A 10-year epidemiological and clinical study. Ann Intern Med. 1982;97:672.
Rynes RI, Mika P, Bartholomew LE. Development of giant cell (temporal) arteritis in a patient “adequately” treated for polymyalgia rheumatica. Ann Rheum Dis. 1977;36:88.
Birkhead NC, Wagener HP, Shick RM. Treatment of temporal arteritis with adrenal corticosteroids: results in 55 cases in which the lesion was proved at biopsy. JAMA. 1975;163:821.
Hollenhorst RW, Brown JR, Wagener HP, et al. Neurologic aspects of temporal arteritis. Neurology. 1960;10:490.
Graham E, Holland A, Avery A, et al. Prognosis in giant-cell arteritis. Br Med J. 1981;282:269.
Hayreh HH. Anterior ischemic optic neuropathy. Differentiation of arteritis from non-arteritic type and its management. Eye. 1990;4:25.
Daiker B, Keller HH. Riesenallarteriitis mit endookulärer Ausbreitung und Hypotonia bulbi dolorosa. Klin Monatsbl Augenheilkund. 1971;158:358.
Wong RL, Korn JH. Temporal arteritis without an elevated erythrocyte sedimentation rate. Am J Med. 1986;80:959.
Andersson R, Malmvall B, Bengtsson B. Acute phase reactants in the initial phase of giant cell arteritis. Acta Med Scand. 1986;220:365.
Kyle V, Cawston TE, Hazleman BL. Erythocyte sedimentation rate and C reactive protein in the assissment of polymyalgia rheumatica/giant cell arteritis on presentation and during followup. Ann Rheum Dis. 1989;48:667.
Desmet GD, Knockaert DC, Bobbaers HJ. Temporal arteritis: the silent presentation and delay in diagnosis. J Int Med. 1990;227:237.
Dasgupta B, Duke O, Timms AM, et al. Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis. Ann Rheum Dis. 1989;48:307.
Hall S, Hunder GG. Is temporal artery biopsy prudent? Mayo Clin Proc. 1984;59:793.
Albert DM, Ruchman MC, Keltner JL. Skip areas in temporal arteritis. Arch Ophthalmol. 1979;94:2072.
Allison MC, Gallagher PJ. Temporal artery biopsy and corticosteroid treatment. Ann Rheum Dis. 1984;43:416.
Hedges TR, Geiger GL, Albert DM. The clinical value of negative temporal artery biopsy specimens. Arch Ophthalmol. 1983;101:1251.
Hall S, Lie JT, Kurland LT, et al. The therapeutic impact of temporal artery biopsy. Lancet. 1983;2:1217.
Cogan DG. Syndrome of nonsyphilitic interstitial keratitis with vestibuloauditory symptoms. Arch Ophthalmol. 1945;33:144.
Cogan DG. Nonsyphilitic keratitis and vestibuloauditory symptoms: four additional cases. Arch Ophthalmol. 1949;42:42.
Cobo LM, Haynes BF. Early corneal findings in Cogan’s syndrome. Ophthalmology. 1980;91:903.
Norton EW, Cogan DG. Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol. 1959;61:695.
Roberts J. Cogan’s syndrome. Med J Aust. 1965;1:186.
Cheson BD. Cogan´s syndrome. Clin Adv Hematol Oncol. 2010;8:833.
Cogan DG, Dickerson GR. Nonsyphilitic interstitial keratitis with vestibuloauditory syndrome: a case with fatal aortitis. Arch Ophthalmol. 1964;71:172.
Haynes BF, Kaiser-Kupfer MI, Mason P, et al. Cogan’s syndrome: studies in thirteen patients, long-term followup, and a review of the literature. Medicine. 1980;59:426.
Eisenstein B, Taubenhaus M. Nonsyphilitic interstitial keratitis and bilateral deafness (Cogan’s syndrome) associated with cardiovascular disease. N Engl J Med. 1958;258:1074.
Fisher ER, Hellstrom HR. Cogan’s syndrome and systemic vascular disease. Arch Pathol. 1961;72:572.
Gelfand ML, Kantor T, Gorstein F. Cogan’s syndrome with cardiovascular involvement; aortic insufficiency. Bull NY Acad Med. 1972;48:647.
Haynes BF, Pikus A, Kaiser-Kupfer MI, et al. Successful treatment of sudden hearing loss in Cogan’s syndrome with corticosteroids. Arthritis Rheum. 1981;24:501.
Bennet FM. Bilateral recurrent episcleritis associated with posterior corneal changes, vestibulo-auditory symptoms and rheumatoid arthritis. Am J Ophthalmol. 1963;55:815.
Watson PG. Management of scleral disease. Trans Ophthalmol Soc UK. 1966;86:151.
Gilbert WS, Talbot FJ. Cogan’s syndrome. Signs of periarteritis nodosa and cerebral venous sinus thrombosis. Arch Ophthalmol. 1969;82:633.
Holt-Wilson AD, Watson PG. Nonsyphilitic deep interstitial keratitis associated with scleritis. Trans Ophthalmol Soc UK. 1974;94:52.
Hedges TR, Taylor GW. Uveal and vestibulo-auditory disease with sarcoid. Arch Ophthalmol. 1952;48:88.
McGavin DDM, McNeill J. Scleritis and perceptive deafness: case report. Ann Ophthalmol. 1979;48:1287.
Coca AF, Cooke RA. On the classification of the phenomena of hypersensitiveness. J Immunol. 1923;8:163.
Duke-Elder S, Leigh AG. Diseases of the outer eye, cornea and sclera. In: Duke-Elder S, editor. System of ophthalmology, vol 8, pt 2. St Louis: CV Mosby Co; 1965.
Braude LS, Chandler JW. Atopic corneal disease. Int Ophthalmol Clin. 1984;24(2):145.
Buckley RJ. Atopic disease of the cornea. In: Cavanagh HD, editor. The cornea: transactions of the world congress of the cornea III. New York: Raven Press; 1988. p. 435–7.
Cassidy JT, Levinson JE, Bass JC, et al. A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis. Arthritis Rheum. 1986;29:274.
Kanski JJ. Juvenile arthritis and uveitis. Surv Ophthalmol. 1990;34:253.
Lyne AJ, Rosen ES. Still’s disease and rheumatoid nodules of the sclera. Br J Ophthalmol. 1968; 52:853.
Watson P. Diseases of the sclera and episclera. In: Duane TD, Jaeger EA, editors. Clinical ophthalmology, vol 4, chap 23. Philadelphia: Harper and Row; 1985.
Ide T, Inoue K. Case of unilateral episcleral sarcoid tubercle. Folia Ophthalmol Jpn. 1968;19:632.
James DG, Anderson R, Langley D, et al. Ocular sarcoidosis. Br J Ophthalmol. 1964;48:461.
Friedman AH, Henkind P. Unusual cases of episcleritis. Trans Am Acad Ophthalmol Otolaryngol. 1974;78:890.
Klein M, Calvert RJ, Joseph WE, et al. Rarities in ocular sarcoidosis. Br J Ophthalmol. 1955;39:416.
Donaldson DD. Sarcoid nodules of iris and of paralimbal sclera. Arch Ophthalmol. 1964;71:246.
Zeiter JH, Bhavsar A, McDermott ML, et al. Ocular sarcoidosis manifesting as an anterior staphyloma. Am J Ophthalmol. 1991;112:3.
Tabbara KF. Scleromalacia associated with Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol. 1988;105:6.
Mackensen F, Smith JR, Rosenbaum JT. Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. Ophthalmology. 2007;114:995.
Daniel E, Gangaputra S, Kempen JH, et al. Recurrent nodular scleritis preceding and adult TINU syndrome. Ocul Immunol Inflamm. 2006;14:239.
Sainz de la Maza M, Foster CS. Necrotizing scleritis after ocular surgery: a clinicopathologic study. Ophthalmology. 1991;98:1720.
Insler MS, Boutros G, Boulware DW. Corneal ulceration following cataract surgery in patients with rheumatoid arthritis. Am Intraocular Implant Soc J. 1985;11:594.
Bloomfield SE, Becker CG, Christian CL, Nauheim JS. Bilateral necrotising scleritis with marginal corneal ulceration after cataract surgery in a patient with vasculitis. Br J Ophthalmol. 1980;64:170.
Rao NA, Marak GE, Hidayat AA. Necrotizing scleritis. A clinico-pathologic study of 41 cases. Ophthalmology. 1985;92:1542.
Collins DH. The subcutaneous nodule of rheumatoid arthritis. J Pathol Bacteriol. 1937;45:97.
Bennett GA, Zeller JW, Bauer W. Subcutaneous nodules of rheumatoid arthritis and rheumatic fever: a pathologic study. Arch Pathol. 1940;30:70.
Kaye BR, Kaye RL, Bobrove A. Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases. Am Rheum Dis. 1964;23:345.
Soter NA, Austen KF. Cutaneous necrotizing angiitis. In: Samter M, et al., editors. Immunological diseases. Boston: Little, Brown & Company; 1978.
McDuffee FD, Sams Jr WM, Maldonado JE. Hypocomplementemia with cutaneous vasculitis and arthritis: possible immune complex syndrome. Mayo Clin Proc. 1973;48:340.
Lyons CJ, Dart JKG, Aclimandos WA, et al. Sclerokeratitis after keratoplasty in atopy. Ophthalmology. 1990;97:729.
Leo RJ, Palmer DJ. Episcleritis and secondary glaucoma after transcleral fixation of a posterior chamber intraocular lens. Arch Ophthalmol. 1991;109:617.
Browning DJ, Proia AD. Ocular rosacea. Sur Ophthalmol. 1986;31:145.
Osgood JK, Dougherty JM, McCulley JP. The role of wax and sterol esters of meibomian secretions in chronic blepharitis. Invest Ophthalmol Vis Sci. 1989;30:1958.
Borrie P. Rosacea with special reference to its ocular manifestations. Br J Dermatol. 1953;65:458.
Richter S. Skleraperforation bei Rosaceokeratitis. Klin Monatsbl Augenheilkd. 1965;146:422.
Hoang-Xuan T, Rodriguez A, Zaltas MM, Rice BA, Foster CS. Ocular rosacea. A histologic and immunopathologic study. Ophthalmology. 1990; 97:1468.
Scharf J, Nahir M, Sharf J. Scleritis associated with hyperuricaemia. Rheumato Tindall. 1975;14:251.
McWilliams JR. Ocular findings in gout. Am J Ophthalmol. 1952;35:1778.
Wood DJ. Inflammatory disease in the eye caused by gout. Br J Ophthalmol. 1936;20:510.
Heinz K. Ocular findings in cases of gout and hyperuricemia. Wien Klin Wochenschr. 1971;83:42.
Fishman RS, Sunderman FW. Band keratopathy in gout. Arch Ophthalmol. 1966;75:367.
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de la Maza, M.S., Tauber, J., Foster, C.S. (2012). Noninfectious Scleritis. In: The Sclera. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6502-8_6
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