Diagnostic Accuracy of FNA of Soft Tissue and Bone Lesions

  • Walid E. Khalbuss
  • Anil V. Parwani
Part of the Essentials in Cytopathology book series (EICP, volume 9)


The diagnosis of bone and soft tissue lesions can be obtained in a variety of ways, including FNA biopsy, core biopsy, or open biopsy. Each of these diagnostic tools has advantages and dis­advantages. When compared to open biopsy, FNA is a simple, outpatient procedure which is well tolerated by patients and has minimal risk of complications. In addition, the multiple trajectories of the FNA biopsy needle make it possible to sample different parts of large tumors, opposed to a single small core biopsy or open biopsy. However, FNA biopsies can have sampling errors attributed to low cellularity, inadequate sampling of the target, and copious cystic/bloody/necrotic material.13 Despite these difficulties, FNA cytologyis being used as a diagnostic modality for initial diagnoses, as well as for recurrences and metastases of soft tissue and bone lesions in numerous medical centers due to its simplicity, low ­morbidity, cost-effectiveness, and ability to issue rapid diagnoses that can facilitate clinical decision making.1


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Copyright information

© Springer US 2011

Authors and Affiliations

  • Walid E. Khalbuss
    • 1
  • Anil V. Parwani
    • 1
  1. 1.Shadyside HospitalUniversity of Pittsburgh Medical CenterPittsburghUSA

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