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The Role of Inflammation in the Generation and Maintenance of Memory T Cells

  • Chapter
Memory T Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 684))

Abstract

Following infection or vaccination, antigen-specific T cells undergo enormous expansion in numbers and differentiate into effector cells that control infection and modulate other aspects of innate and adaptive immunity. The effector T-cell expansion phase is followed by an abrupt period of contraction, during which 90–95% of antigen-specific T cells are eliminated. The surviving pool of T cells subsequently differentiates into long-lived memory populations that can persist for the life of the host and mediate enhanced protective immunity following pathogen re-infection. The generation and maintenance of memory T-cell populations are influenced by a multitude of factors, including inflammatory cytokines that can act on T cells at various points during their differentiation. Herein, we discuss our current understanding of how inflammation shapes not only the quantity and quality of memory T cells, but also the rate at which functional memory T-cell populations develop.

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Authors and Affiliations

  1. Department of Microbiology, University of Iowa, Iowa City, Iowa, 52242, USA

    Noah S. Butler & John T. Harty

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  1. Noah S. Butler
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  2. John T. Harty
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Correspondence to John T. Harty .

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Editors and Affiliations

  1. The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA

    Maurizio Zanetti MD (Professor of Medicine) (Professor of Medicine)

  2. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P. Schoenberger PhD (member in the Laboratory of Cellular Immunology) (member in the Laboratory of Cellular Immunology)

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Butler, N.S., Harty, J.T. (2010). The Role of Inflammation in the Generation and Maintenance of Memory T Cells. In: Zanetti, M., Schoenberger, S.P. (eds) Memory T Cells. Advances in Experimental Medicine and Biology, vol 684. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6451-9_4

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