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Memory T-Cell Subsets in Parasitic Infections

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Memory T Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 684))

Abstract

Parasitic infections remain a major health problem throughout the world and unlike many viral or bacterial diseases, there are no vaccines to help control parasitic diseases. While several important advances have been made that will contribute to the development of parasite vaccines, such as cloning of dominant parasite antigens and a better understanding of the effector T-cell subsets needed for immunity, fundamental questions remain about how to induce long-term immunologic memory in vaccines. Here we examine a few of the experimental models that have been used to elucidate the nature of the memory T cells that are generated during parasitic infections. Although significant hurdles remain in the development of parasite vaccines, studies with both protozoa and gastrointestinal nematodes suggest that long-term immunity induced by vaccination is a realistic goal for control of parasitic infections.

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Authors and Affiliations

  1. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 310 Hill Pavilion, 380 South University Avenue, Philadelphia, Pennslyvania, 19104-4539, USA

    Sara Colpitts & Phillip Scott

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  1. Sara Colpitts
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  2. Phillip Scott
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Correspondence to Phillip Scott .

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Editors and Affiliations

  1. The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA

    Maurizio Zanetti MD (Professor of Medicine) (Professor of Medicine)

  2. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P. Schoenberger PhD (member in the Laboratory of Cellular Immunology) (member in the Laboratory of Cellular Immunology)

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Colpitts, S., Scott, P. (2010). Memory T-Cell Subsets in Parasitic Infections. In: Zanetti, M., Schoenberger, S.P. (eds) Memory T Cells. Advances in Experimental Medicine and Biology, vol 684. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6451-9_11

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