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Diseases of DNA Repair pp 95–105Cite as

Hereditary Photodermatoses

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 685))

Abstract

Photodermatoses are defined as the abnormal reactions of the skin to photons, usually those of wavelengths found in sunlight. These reactions can be caused by a wide variety of reasons, including defects in repair of light-induced DNA lesions, the interaction of certain chemicals or medications with sunlight to produce toxic mediators and photo-induced immune reactions. In this chapter we will describe photodermatoses that are associated with hereditary conditions. These can be subdivided into several groups: dermatoses caused by abnormal metabolic conditions, idiopathic photodermatoses, defects in cancer suppressor genes not directly involved in DNA repair but that predispose to photodistributed tumors and photosensitivity due to abnormalities in DNA repair pathways. Special emphasis will be placed on the relatively recently described UV-sensitive sy

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of California at San Francisco, San Francisco, California, USA

    Dennis H. Oh

  2. Department of Biology, Stanford University, Stanford, California, 94305, USA

    Graciela Spivak

Authors
  1. Dennis H. Oh
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  2. Graciela Spivak
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Corresponding author

Correspondence to Graciela Spivak .

Editor information

Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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© 2010 Landes Bioscience and Springer Science+Business Media

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Oh, D.H., Spivak, G. (2010). Hereditary Photodermatoses. In: Ahmad, S.I. (eds) Diseases of DNA Repair. Advances in Experimental Medicine and Biology, vol 685. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6448-9_9

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