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MSH Radiopeptides for Targeting Melanoma Metastases

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Melanocortins: Multiple Actions and Therapeutic Potential

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 681))

Abstract

Radiolabeled peptides have become important tools for preclinical cancer research and in nuclear oncology they serve as diagnostic and more recently also as therapeutic agents. Whereas the development of receptor-mediated targeting for therapy has been confined to some radiolabeled antibodies and somatostatin/SRIF analogs, recent research into radiolabeled α-Melanocyte-stimulating hormone (α-MSH) and its receptor MC1R (over-)expressed by melanoma tumor cells has demonstrated that small metastatic melanoma lesions in experimental animals are specifically targeted by MSH radiopeptides. Thus MSH radiopharmaceuticals will eventually open a new avenue for the treatment of melanoma metastases in man, provided that the targeting efficiency can be further enhanced and nonspecific incorporation into nontarget organs, e.g., the kidneys, minimized. Some novel MSH lead compounds containing a glyco moiety, added negatively charged groups or a cyclic structure show very promising in vivo targeting characteristics.

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Author information

Authors and Affiliations

  1. Laboratory of Endocrinology, Department of Biomedicine, University Hospital Basel and University Children’s Hospital, University of Basel, Klingelbergstrasse 23, CH-4031, Basel, Switzerland

    Alex N. Eberle, Jean-Philippe Bapst, Martine Calame & Heidi Tanner

  2. Actelion Pharmaceuticals, Ltd, Allschwil, Switzerland

    Sylvie Froidevaux

Authors
  1. Alex N. Eberle
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  2. Jean-Philippe Bapst
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  3. Martine Calame
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  4. Heidi Tanner
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  5. Sylvie Froidevaux
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Editor information

Editors and Affiliations

  1. Fondazione IRCCS, Center for Preclinical Investigation, Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy

    Anna Catania MD

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Eberle, A.N., Bapst, JP., Calame, M., Tanner, H., Froidevaux, S. (2010). MSH Radiopeptides for Targeting Melanoma Metastases. In: Catania, A. (eds) Melanocortins: Multiple Actions and Therapeutic Potential. Advances in Experimental Medicine and Biology, vol 681. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6354-3_11

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