Abstract
With changes in the approach to treatment of childhood leukemia and brain tumors, more children are surviving into adulthood. With this increase in long-term survivorship, long-term neurocognitive side effects have emerged. Research has shown that these survivors suffer a variety of neurocognitive effects including changes in attention span, concentration, school performance and executive functioning. Researchers continue to study changes in therapy with the hopes of decreasing these long-term side effects without compromising overall survival rates. Others have focused on developing adaptations to how these children learn, equipping them with tools to better cope with learning deficits. Still, others have looked into pharmacological interventions. This chapter will discuss the historical course of therapy for both leukemia and brain tumors. In addition, it will highlight how late effect studies guided changes in therapeutic approach for both childhood leukemias and brain tumors. This chapter will also discuss specific neurocognitive effects from childhood cancer treatment, challenges in research methodologies as well as current pharmacological and nonpharmacological interventions for affected childhood cancer survivors.
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References
American Cancer Society. Cancer Facts and Figures 2009. Atlanta, GA: American Cancer Society. From http://www.cancer.org/downloads/STT/500809web.pdf (accessed 2009). Summarizes current scientific and statistical information for types of cancer.
Anderson FS, Kunin-Batson AS. Neurocognitive late effects of chemotherapy in children: the past 10 years of research on brain structure and function. Pediatr Blood Cancer 2009; 52:159–164. Literature review of neurocognitive late effects after chemotherapy and proposed neural mechanisms.
Gamis AS, Nesbit ME. Neuropsychologic (cognitive) disabilities in long-term survivors of childhood cancer. Pediatrician 1991; 18:11–19. Highlights characteristics of childhood cancer patients at risk for neuropsychologic sequelae.
Copeland DR, Moore BD, Francis DJ et al. Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. J Clin Oncol 1996; 14:2826–2835. Highlights characteristics of childhood cancer patients at risk for neuropsychologic sequelae.
Janzen LA, Spiegler BJ. Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment. Dev Disabil Res Rev 2008; 14:185–195. Discusses neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia and reviews methodological issues, treatment factors and risks and moderators.
Evans AE, Gilbert ES, Zandstra R. The increasing incidence of central nervous system leukemia in children. Cancer 1970; 26:404–409. Highlights the state of the science of regarding central nervous system disease in children with leukemia.
Meadows AT, Evans AE. Effects of chemotherapy on the central nervous system. A study of parenteral methotrexate in long-term survivors of leukemia and lymphoma in childhood. Cancer 1976; 37(2 Suppl):1079–1085. One of the earliest studies highlighting the long-term neurocognitive effects of chemotherapy of childhood cancer survivors.
Moss HA, Nannis ED, Poplack DG. The effects of prophylactic treatment of the central nervous system in the intellectual functioning of children with acute lymphocytic leukemia. Am J Med 1981; 71:47–52. Highlights the correlation of prophylactic radiation and academic deficits of childhood leukemia survivors.
Lockwood KA, Bell TS, Colegrove RW. Long-term effects of cranial radiation therapy on attention functioning in survivors of childhood leukemia. J Pediatr Psychol 1999; 24:55–66. Discusses the history of cranial radiation therapy in treatment of childhood leukemia as well as the associated neurocognitive late effects in childhood leukemia survivors.
Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukemia. Lancet Oncol 2008; 9:257–268. Explains risk stratification and treatment of childhood leukemia.
Butler RW, Haser JK. Neurocognitive effects of treatment for childhood cancer. MRDD Research Reviews 2006; 12:184–191. Provides a historical foundation and research review on the neuropsychological effects that central nervous system cancer treatments have on the cognitive abilities of pediatric cancer survivors.
Ryan-Murray J, McElwain Petriccione M. Central Nervous System Tumors. In: Nelson Cullen B, ed. Nursing Care of Children and Adolescents with Cancer, 3rd ed. Philadelphia: WB Saunders Company, 2002: 503–523. Summarizes current treatments of central nervous system tumors.
Butler RW, Copeland DR. Attentional processes and their remediation in children treated for cancer: a literature review and the development of a therapeutic approach. J Int Neuropsychol 2002; 8:113–124. Discusses role of cognitive remediation programs in improving attentional deficits of childhood cancer survivors.
Mulhern RK, Khan RB, Kaplan S. Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. J Clin Oncol 2004; 22(23)4795–4803. Examines the role of methylphenidate in improving neurocognition amongst childhood cancer survivors.
Conklin HM, Khan RB, Reddick WE et al. Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. J Pediatr Psychol 2007; 32(9):1127–1139. Examines the role of methylphenidate in improving neurocognition amongst childhood cancer survivors.
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Costa, J. (2010). Neurocognitive Effects of Childhood Cancer Treatment. In: Raffa, R.B., Tallarida, R.J. (eds) Chemo Fog. Advances in Experimental Medicine and Biology, vol 678. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6306-2_6
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DOI: https://doi.org/10.1007/978-1-4419-6306-2_6
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