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Gene Therapy for Malignant Pleural Mesothelioma

  • Edmund K. Moon
  • Sunil Singhal
  • Andrew R. Haas
  • Daniel H. Sterman
  • Steven M. Albelda
Chapter
Part of the Current Cancer Research book series (CUCR)

Abstract

Malignant pleural mesothelioma (MPM) is a neoplasm of the intrathoracic cavity associated with asbestos exposure that presents with symptoms of dyspnea, a pleural effusion, and nonpleuritic chest pain. MPM is associated with a poor prognosis with current treatment regimens having only a modest effect on its progressive course. However, a number of preclinical and early clinical studies have been performed investigating novel gene therapy strategies that have the potential of positively impacting the disease course. These strategies include induction of apoptosis, angiogenesis blockade, suicide gene expression, immunogene therapy, and viral oncolysis.

Keywords

Malignant pleural mesothelioma Gene therapy Apoptosis Antiangiogenesis Suicide gene therapy Immunogene therapy Viral oncalysis 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Edmund K. Moon
  • Sunil Singhal
  • Andrew R. Haas
  • Daniel H. Sterman
  • Steven M. Albelda
    • 1
  1. 1.Pulmonary, Allergy, and Critical Care Division, Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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