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Novel and Future Treatment Strategies

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Biofilm Infections

Abstract

The biofilm mode of life is by many scientists acknowledged as a successful, bacterial survival strategy in hostile environments. When bacteria invade their hosts, they encounter harsh conditions such as low levels of iron, oxidative stress, macerating enzymes, phagocytic cells, and host-derived as well as administered antimicrobials. Experimental evidence has accumulated over the years showing that biofilms tolerate antimicrobial properties of the immune system and antibiotics. This multifaceted tolerance relies to a certain extend on general resistance mechanisms including efflux pumps and enzymatic modifications in addition to innate tolerances offered by integral structure-functions of the biofilm.

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Authors and Affiliations

  1. Department of Systems Biology, Technical University of Denmark, DK-2800, Lyngby, Denmark

    Morten Alhede

  2. Department of International Health, Immunology and Microbiology, University of Copenhagen, DK-2200, Copenhagen, Denmark

    Tim Holm Jakobsen

  3. Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    Michael Givskov

Authors
  1. Morten Alhede
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  2. Tim Holm Jakobsen
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  3. Michael Givskov
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Corresponding author

Correspondence to Michael Givskov .

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Editors and Affiliations

  1. Faculty of Health Sciences, Department of International Health, Immu, University of Copenhagen, Blegdamsvej 3B, Copenhagen Ø, DK-2200, Denmark

    Thomas Bjarnsholt

  2. Afsnit 9301, Department Clinical Microbiology, H:S Rigshospitalet, Juliane Maries Vej 22, Copenhagen Ø, DK-2100, Denmark

    Peter Østrup Jensen

  3. Afsnit 9301, Department for Clinical Microbiology, H:S Rigshospitalet, Juliane Maries Vej 22, Copenhagen Ø, DK-2100, Denmark

    Claus Moser

  4. Faculty of Health Sciences, Department of International Health, Immu, University of Copenhagen, Blegdamsveg 3B, Copenhagen Ø, DK-2100, Denmark

    Niels Høiby

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Alhede, M., Jakobsen, T.H., Givskov, M. (2011). Novel and Future Treatment Strategies. In: Bjarnsholt, T., Jensen, P., Moser, C., Høiby, N. (eds) Biofilm Infections. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6084-9_14

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