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Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum

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Molecular Genetics of Liver Neoplasia

Part of the book series: Cancer Genetics ((CANGENETICS))

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Abstract

Intrahepatic cholangiocarcinoma, second in incidence to hepatocellular carcinoma among the primary liver carcinomas, has an even more dismal prognosis. Intrahepatic cholangiocarcinoma is difficult to diagnose at an early stage of development and advances aggressively, with widespread metastases. Molecular genetic features of intrahepatic cholangiocarcinoma have been partially elucidated, although the specific genetic lesions and molecular processes that drive its development, progression, and metastasis are still obscure. Evidence has accumulated from many sources suggesting that cholangiocarcinoma and hepatocellular carcinoma are components of a spectrum of primary liver carcinomas, including poorly and aberrantly differentiated varieties. Primary liver carcinomas arise from cells in different stages of development that encompass the entire lineage of liver epithelial cells generated from hepatoblasts and/or adult liver stem cells, and share critical genomic aberrations and phenotypes with these progenitor cells.

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Authors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

    Joe W. Grisham (Kenan Professor of Pathology and Laboratory Emeritus)

  2. Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, MSC 4258, Building 37, Room 3044A, Bethesda, MD, 20892, USA

    Xin Wei Wang Ph.D (Senior Investigator, Head)

  3. Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 4146A, 37 Convent Drive MSC 4262, Bethesda, MD, 20892-4262, USA

    Snorri S. Thorgeirsson M.D., Ph.D. (Head, Center of Excellence in Integrative Cancer Biology and Genomics Chief)

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  1. Joe W. Grisham
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Correspondence to Joe W. Grisham .

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Editors and Affiliations

  1. Lab. Human Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Xin Wei Wang

  2. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Joe W. Grisham

  3. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Snorri S. Thorgeirsson

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Grisham, J.W., Wang, X.W., Thorgeirsson, S.S. (2010). Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum. In: Wang, X., Grisham, J., Thorgeirsson, S. (eds) Molecular Genetics of Liver Neoplasia. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6082-5_2

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