Integrative and Functional Genomics of HCC
In this chapter, we review the impact of functional and integrative genomics on hepatocellular carcinoma (HCC) research over the last decade. We focus on how genome-wide and high-throughput technologies have been used successfully to classify HCC at a molecular level and became important tools to refine the diagnosis and prognosis predictions of HCC. We also describe how cross-species comparative oncogenomic emerged as a powerful strategy to improve HCC prognostication, as well as to highlight evolutionally conserved regulatory modules or pathways that may be critical in hepatocarcinogenesis. In order to achieve a complete understanding of the molecular mechanisms involved in the disease, the field is now shifting toward integrative genomics, which now combines multi-parametric data reflecting alterations at genomic, genetic and epigenetic levels. Undoubtedly, functional and integrative genomics promise to yield unprecedented biological insights into the pathogenesis of HCC and will ultimately converge toward a personalized medicine that will improve diagnosis, treatment and prevention of liver cancer.