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Mediastinum and Thymus

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Abstract

This chapter reviews the clinical, macroscopic, and microscopic features, as well as the differential diagnosis and classifications, of the most common mediastinal lesions seen in a routine surgical pathology or autopsy practice. It begins with non-neoplastic lesions including those associated with inflammatory/infectious processes, cystic lesions, and non-neoplastic lesions of the thymus. This is followed by a review of ectopically located thyroid and parathyroid lesions mimicking primary mediastinal tumors. Next are the neoplastic lesions, including tumors of the thymus (with an emphasis on thymoma) and tumors not limited to the thymus such as neurogenic tumors, paraganglioma, germ cell tumors, lymphoproliferative disorders, mesenchymal tumors, and metastatic tumors. Applicable ancillary testing modalities including immunohistochemistry are mentioned for each entity, and several summary tables as well as numerous photomicrographs are included to facilitate use of this chapter as a quick reference guide to the surgical pathology of mediastinal lesions.

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Authors and Affiliations

  1. Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Weill Medical College of Cornell University, Houston, TX, USA

    Chung-Che (Jeff) Chang MD, PhD

  2. Department of Pathology, The Methodist Hospital, Houston, TX, USA

    Munir Shahjahan MD

  3. Department of Pathology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH, USA

    Joseph F. Tomashefski Jr. MD

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  1. Chung-Che (Jeff) Chang MD, PhD
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  2. Munir Shahjahan MD
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  3. Joseph F. Tomashefski Jr. MD
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Editors and Affiliations

  1. School of Medicine, Dept. Pathology, Indiana University, N. University Blvd. 550, Indianapolis, 46202, Indiana, USA

    Liang Cheng

  2. Bostwick Laboratories, N. Parham Rd. 2807, Richmond, 23294, Virgin Islands, USA

    David G. Bostwick

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Chang, CC.(., Shahjahan, M., Tomashefski, J.F. (2011). Mediastinum and Thymus. In: Cheng, L., Bostwick, D. (eds) Essentials of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6043-6_26

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