Skip to main content

Anesthetic Complications in the Neonate

  • Chapter
  • First Online:
  • 2025 Accesses

Abstract

The neonate is at risk for increased perianesthetic complications attributed, in part, to such factors as the transitional circulation and the immaturity of many organ systems and metabolic processes. In the preterm neonate, incomplete maturation of all organ systems, in particular the pulmonary and cardiovascular systems, further magnifies the risks in the perioperative period. Neonatal surgical or interventional procedures, such as repair or palliation of major congenital anomalies or management of life-threatening complications of prematurity, are rarely elective. Excellent communication and collaboration among the neonatal, anesthesia, and surgical teams are essential to optimize the outcome. Despite best intentions, preparation, and experience, perianesthetic adverse events confront all practitioners. The discussion of complications and risks for all procedures and therapeutic options is beyond the scope of this chapter; therefore, the focus here is to provide an overview of the adverse events to which neonates are particularly vulnerable and of the potential risks from anesthetic agents.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Beecher HK, Todd DP. A study of the deaths associated with anesthesia and surgery: based on a study of 599, 548 anesthesias in ten institutions 1948-1952, inclusive. Ann Surg. 1954;140:2–35.

    PubMed Central  CAS  PubMed  Google Scholar 

  2. Phillips OC, Frazier TM, Graff TD, Dekornfeld TJ. The Baltimore anesthesia study committee. Review of 1,024 postoperative deaths. JAMA. 1960;174:2015–9.

    CAS  PubMed  Google Scholar 

  3. Rackow H, Salanitre E, Green LT. Frequency of cardiac arrest associated with anesthesia in infants and children. Pediatrics. 1961;28:697–704.

    CAS  PubMed  Google Scholar 

  4. Smith RM. Anesthesia for infants and children. St. Louis: Mosby; 1959.

    Google Scholar 

  5. Graff TD, Phillips OC, Benson DW, Kelley E. Baltimore anesthesia study committee: factors in pediatric anesthesia mortality. Anesth Analg. 1964;43:407–14.

    CAS  PubMed  Google Scholar 

  6. van der Griend BF, Lister NA, McKenzie IM, et al. Postoperative mortality in children after 101,885 anesthetics at a tertiary pediatric hospital. Anesth Analg. 2011;112(6):1440.

    PubMed  Google Scholar 

  7. Bhananker SM, Ramamoorthy C, Geiduschek JM, et al. Anesthesia-related cardiac arrest in children: update from the pediatric perioperative cardiac arrest registry. Anesth Analg. 2007;105:344–50.

    PubMed  Google Scholar 

  8. Bunchungmongkol N, Somboonviboon W, Suraseranivongse S, Vasinanukorn M, Chau-in W, Hintong T. Pediatric anesthesia adverse events: the Thai Anesthesia Incidents Study (THAI Study) database of 25,098 cases. J Med Assoc Thai. 2007;90:2072–9.

    PubMed  Google Scholar 

  9. Cohen MM, Cameron CB, Duncan PG. Pediatric anesthesia morbidity and mortality in the perioperative period. Anesth Analg. 1990;70:160–7.

    CAS  PubMed  Google Scholar 

  10. Flick RP, Sprung J, Harrison TE, et al. Perioperative cardiac arrests in children between 1988 and 2005 at a tertiary referral center: a study of 92,881 patients. Anesthesiology. 2007;106:226–37. quiz 413-4.

    PubMed  Google Scholar 

  11. Jimenez N, Posner KL, Cheney FW, Caplan RA, Lee LA, Domino KB. An update on pediatric anesthesia liability: a closed claims analysis. Anesth Analg. 2007;104:147–53.

    PubMed  Google Scholar 

  12. Kakavouli A, Li G, Carson MP, et al. Intraoperative reported adverse events in children. Paediatr Anaesth. 2009;19:732–9.

    PubMed Central  PubMed  Google Scholar 

  13. Kawashima Y, Seo N, Morita K, et al. Anesthesia-related mortality and morbidity in Japan (1999). J Anesth. 2002;16:319–31.

    PubMed  Google Scholar 

  14. Keenan RL, Shapiro JH, Kane FR, Simpson PM. Bradycardia during anesthesia in infants. An epidemiologic study. Anesthesiology. 1994;80:976–82.

    CAS  PubMed  Google Scholar 

  15. Marcus R. Human factors in pediatric anesthesia incidents. Paediatr Anaesth. 2006;16:242–50.

    CAS  PubMed  Google Scholar 

  16. Morita K, Kawashima Y, Irita K. Perioperative mortality and morbidity in 1999 with a special reference to age in 466 certified training hospitals of Japanese Society of Anesthesiologists–report of Committee on Operating Room Safety of Japanese Society of Anesthesiologists. Masui. 2001;50:909–21.

    CAS  PubMed  Google Scholar 

  17. Morray JP, Geiduschek JM, Caplan RA, Posner KL, Gild WM, Cheney FW. A comparison of pediatric and adult anesthesia closed malpractice claims. Anesthesiology. 1993;78:461–7.

    CAS  PubMed  Google Scholar 

  18. Morray JP, Geiduschek JM, Ramamoorthy C, et al. Anesthesia-related cardiac arrest in children: initial findings of the pediatric perioperative cardiac arrest (POCA) registry. Anesthesiology. 2000;93:6–14.

    CAS  PubMed  Google Scholar 

  19. Murat I, Constant I, Maud'huy H. Perioperative anaesthetic morbidity in children: a database of 24,165 anaesthetics over a 30-month period. Paediatr Anaesth. 2004;14:158–66.

    PubMed  Google Scholar 

  20. Olsson GL, Hallen B. Laryngospasm during anaesthesia. A computer-aided incidence study in 136,929 patients. Acta Anaesthesiol Scand. 1984;28:567–75.

    CAS  PubMed  Google Scholar 

  21. Olsson GL, Hallen B. Cardiac arrest during anaesthesia. A computer-aided study in 250,543 anaesthetics. Acta Anaesthesiol Scand. 1988;32:653–64.

    CAS  PubMed  Google Scholar 

  22. Tay CL, Tan GM, Ng SB. Critical incidents in paediatric anaesthesia: an audit of 10 000 anaesthetics in Singapore. Paediatr Anaesth. 2001;11:711–8.

    CAS  PubMed  Google Scholar 

  23. Tiret L, Nivoche Y, Hatton F, Desmonts JM, Vourc'h G. Complications related to anaesthesia in infants and children. A prospective survey of 40240 anaesthetics. Br J Anaesth. 1988;61:263–9.

    CAS  PubMed  Google Scholar 

  24. Van der Walt JH, Sweeney DB, Runciman WB, Webb RK. The Australian Incident Monitoring Study. Paediatric incidents in anaesthesia: an analysis of 2000 incident reports. Anaesth Intensive Care. 1993;21:655–8.

    PubMed  Google Scholar 

  25. Leape LL. Error in medicine. JAMA. 1994;272:1851–7.

    CAS  PubMed  Google Scholar 

  26. Smith AF, Goodwin D, Mort M, Pope C. Adverse events in anaesthetic practice: qualitative study of definition, discussion and reporting. Br J Anaesth. 2006;96:715–21.

    CAS  PubMed  Google Scholar 

  27. Stanhope N, Crowley-Murphy M, Vincent C, O'Connor AM, Taylor-Adams SE. An evaluation of adverse incident reporting. J Eval Clin Pract. 1999;5:5–12.

    CAS  PubMed  Google Scholar 

  28. Taylor JA, Brownstein D, Christakis DA, et al. Use of incident reports by physicians and nurses to document medical errors in pediatric patients. Pediatrics. 2004;114:729–35.

    PubMed  Google Scholar 

  29. Derrington MC, Smith G. A review of studies of anaesthetic risk, morbidity and mortality. Br J Anaesth. 1987;59:815–33.

    CAS  PubMed  Google Scholar 

  30. Odegard KC, DiNardo JA, Kussman BD, et al. The frequency of anesthesia-related cardiac arrests in patients with congenital heart disease undergoing cardiac surgery. Anesth Analg. 2007;105:335–43.

    PubMed  Google Scholar 

  31. Ramamoorthy C, Haberkern CM, Bhananker SM, et al. Anesthesia-related cardiac arrest in children with heart disease: data from the pediatric perioperative cardiac arrest (POCA) registry. Anesth Analg. 2010;110:1376–82.

    CAS  PubMed  Google Scholar 

  32. Hansen G, Joffe AR, Nettel-Aguirre A, et al. Two-year survival and neurodevelopmental outcomes after cardiopulmonary resuscitation in neonatal patients after complex cardiac surgery. Resuscitation. 2011;82:313–8.

    PubMed  Google Scholar 

  33. Meaney PA, Nadkarni VM, Cook EF, et al. Higher survival rates among younger patients after pediatric intensive care unit cardiac arrests. Pediatrics. 2006;118:2424–33.

    PubMed  Google Scholar 

  34. Paterson N, Waterhouse P. Risk in pediatric anesthesia. Paediatr Anaesth. 2011;21:848–57.

    PubMed  Google Scholar 

  35. Fenner A, Schalk U, Hoenicke H, Wendenburg A, Roehling T. Periodic breathing in premature and neonatal babies: incidence, breathing pattern, respiratory gas tensions, response to changes in the composition of ambient air. Pediatr Res. 1973;7:174–83.

    CAS  PubMed  Google Scholar 

  36. Kelly DH, Stellwagen LM, Kaitz E, Shannon DC. Apnea and periodic breathing in normal full-term infants during the first twelve months. Pediatr Pulmonol. 1985;1:215–9.

    CAS  PubMed  Google Scholar 

  37. Hoppenbrouwers T, Hodgman JE, Harper RM, Hofmann E, Sterman MB, McGinty DJ. Polygraphic studies of normal infants during the first six months of life: III. Incidence of apnea and periodic breathing. Pediatrics. 1977;60:418–25.

    CAS  PubMed  Google Scholar 

  38. Kurth CD, LeBard SE. Association of postoperative apnea, airway obstruction, and hypoxemia in former premature infants. Anesthesiology. 1991;75:22–6.

    CAS  PubMed  Google Scholar 

  39. Steward DJ. Preterm infants are more prone to complications following minor surgery than are term infants. Anesthesiology. 1982;56:304–6.

    CAS  PubMed  Google Scholar 

  40. Cote CJ, Zaslavsky A, Downes JJ, et al. Postoperative apnea in former preterm infants after inguinal herniorrhaphy. A combined analysis. Anesthesiology. 1995;82:809–22.

    CAS  PubMed  Google Scholar 

  41. Fisher DM. When is the ex-premature infant no longer at risk for apnea? Anesthesiology. 1995;82:807–8.

    CAS  PubMed  Google Scholar 

  42. Craven PD, Badawi N, Henderson-Smart DJ, O'Brien M. Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy. Cochrane Database Syst Rev 2003:CD003669.

    Google Scholar 

  43. Gerber AC, Weiss M. Awake spinal or caudal anaesthesia in preterms for herniotomies: what is the evidence based benefit compared with general anaesthesia? Curr Opin Anaesthesiol. 2003;16:315–20.

    PubMed  Google Scholar 

  44. Frumiento C, Abajian JC, Vane DW. Spinal anesthesia for preterm infants undergoing inguinal hernia repair. Arch Surg. 2000;135:445–51.

    CAS  PubMed  Google Scholar 

  45. Kunst G, Linderkamp O, Holle R, Motsch J, Martin E. The proportion of high risk preterm infants with postoperative apnea and bradycardia is the same after general and spinal anesthesia. Can J Anaesth. 1999;46:94–5.

    CAS  PubMed  Google Scholar 

  46. Krane EJ, Haberkern CM, Jacobson LE. Postoperative apnea, bradycardia, and oxygen desaturation in formerly premature infants: prospective comparison of spinal and general anesthesia. Anesth Analg. 1995;80:7–13.

    CAS  PubMed  Google Scholar 

  47. Davidson A, Frawley GP, Sheppard S, Hunt R, Hardy P. Risk factors for apnea after infant inguinal hernia repair. Paediatr Anaesth. 2009;19:402–3.

    PubMed  Google Scholar 

  48. Kim J, Thornton J, Eipe N. Spinal anesthesia for the premature infant: is this really the answer to avoiding postoperative apnea? Paediatr Anaesth. 2009;19:56–8.

    PubMed  Google Scholar 

  49. O'Brien K, Robinson DN, Morton NS. Induction and emergence in infants less than 60 weeks post-conceptual age: comparison of thiopental, halothane, sevoflurane and desflurane. Br J Anaesth. 1998;80:456–9.

    PubMed  Google Scholar 

  50. Sale SM, Read JA, Stoddart PA, Wolf AR. Prospective comparison of sevoflurane and desflurane in formerly premature infants undergoing inguinal herniotomy. Br J Anaesth. 2006;96:774–8.

    CAS  PubMed  Google Scholar 

  51. Murphy JJ, Swanson T, Ansermino M, Milner R. The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? J Pediatr Surg. 2008;43:865–8.

    PubMed  Google Scholar 

  52. William JM, Stoddart PA, Williams SA, Wolf AR. Post-operative recovery after inguinal herniotomy in ex-premature infants: comparison between sevoflurane and spinal anaesthesia. Br J Anaesth. 2001;86:366–71.

    CAS  PubMed  Google Scholar 

  53. Somri M, Coran AG, Mattar I, et al. The postoperative occurrence of cardio-respiratory adverse events in small infants undergoing gastrointestinal surgery: a prospective comparison of general anesthesia and combined spinal-epidural anesthesia. Pediatr Surg Int. 2011;27(11):1173–8.

    PubMed  Google Scholar 

  54. Welborn LG, Greenspun JC. Anesthesia and apnea. Perioperative considerations in the former preterm infant. Pediatr Clin North Am. 1994;41:181–98.

    CAS  PubMed  Google Scholar 

  55. Henderson-Smart DJ, Steer P. Prophylactic caffeine to prevent postoperative apnea following general anesthesia in preterm infants. Cochrane Database Syst Rev 2001:CD000048.

    Google Scholar 

  56. Henderson-Smart DJ, Davis PG. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane Database Syst Rev 2010:CD000139.

    Google Scholar 

  57. Kumral A, Tuzun F, Vesilirmak DC, et al. Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms: genetic basis of apnoea of prematurity. Acta Paediatr. 2012;101:e299–303.

    CAS  PubMed  Google Scholar 

  58. Zagol K, Lake DE, Vergales B, et al. Anemia, apnea of prematurity, and blood transfusions. J Pediatr. 2012;161:417–21.

    PubMed  Google Scholar 

  59. Khemani RG, Randolph A, Markovitz B. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev 2009:CD001000 pub3.

    Google Scholar 

  60. Davies MW, Davis PG. Nebulized racemic epinephrine for extubation of newborn infants. Cochrane Database Syst Rev 2002:CD000506.

    Google Scholar 

  61. Davis PG, Henderson-Smart DJ. Intravenous dexamethasone for extubation of newborn infants. Cochrane Database Syst Rev 2001;(4):CD 000308.

    Google Scholar 

  62. de Cesar RG, Carvalho WB. L-epinephrine and dexamethasone in postextubation airway obstruction: a prospective, randomized, double-blind placebo-controlled study. Int J Pediatr Otorhinolaryngol. 2009;73:1639–43.

    PubMed  Google Scholar 

  63. Dankle SK, Schuller DE, McClead RE. Risk factors for neonatal acquired subglottic stenosis. Ann Otol Rhinol Laryngol. 1986;95:626–30.

    CAS  PubMed  Google Scholar 

  64. Jones R, Bodnar A, Roan Y, Johnson D. Subglottic stenosis in newborn intensive care unit graduates. Am J Dis Child. 1981;135:367–8.

    CAS  PubMed  Google Scholar 

  65. Parkin JL, Stevens MH, Jung AL. Acquired and congenital subglottic stenosis in the infant. Ann Otol Rhinol Laryngol. 1976;85:573–81.

    CAS  PubMed  Google Scholar 

  66. Walner DL, Loewen MS, Kimura RE. Neonatal subglottic stenosis–incidence and trends. Laryngoscope. 2001;111:48–51.

    CAS  PubMed  Google Scholar 

  67. Miller JD, Carlo WA. Pulmonary complications of mechanical ventilation in neonates. Clin Perinatol. 2008;35:273–81.

    PubMed  Google Scholar 

  68. Sherman JM, Lowitt S, Stephenson C, Ironson G. Factors influencing acquired subglottic stenosis in infants. J Pediatr. 1986;109:322–7.

    CAS  PubMed  Google Scholar 

  69. Mossad E, Youssef G. Subglottic stenosis in children undergoing repair of congenital heart defects. J Cardiothorac Vasc Anesth. 2009;23:658–62.

    PubMed  Google Scholar 

  70. Borland LM, Sereika SM, Woelfel SK, et al. Pulmonary aspiration in pediatric patients during general anesthesia: incidence and outcome. J Clin Anesth. 1998;10:95–102.

    CAS  PubMed  Google Scholar 

  71. Warner MA, Warner ME, Warner DO, Warner LO, Warner EJ. Perioperative pulmonary aspiration in infants and children. Anesthesiology. 1999;90:66–71.

    CAS  PubMed  Google Scholar 

  72. Maclennan AI, Smith AF. An analysis of critical incidents relevant to pediatric anesthesia reported to the UK National Reporting and Learning System, 2006-2008. Paediatr Anaesth. 2010;21(8):841–7.

    PubMed  Google Scholar 

  73. Finer NN, Woo BC, Hayashi A, Hayes B. Neonatal surgery: intensive care unit versus operating room. J pediatr surg. 1993;28:645–9.

    CAS  PubMed  Google Scholar 

  74. Gavilanes AW, Heineman E, Herpers MJ, Blanco CE. Use of neonatal intensive care unit as a safe place for neonatal surgery. Arch Dis Child Fetal Neonatal Ed. 1997;76:F51–3.

    PubMed Central  CAS  PubMed  Google Scholar 

  75. Mallick MS, Jado AM, Al-Bassam AR. Surgical procedures performed in the neonatal intensive care unit on critically ill neonates: feasibility and safety. Ann Saudi Med. 2008;28:105–8.

    PubMed  Google Scholar 

  76. Taylor RL, Grover FL, Harman PK, Escobedo MK, Ramamurthy RS, Trinkle JK. Operative closure of patent ductus arteriosus in premature infants in the neonatal intensive care unit. Am J Surg. 1986;152:704–8.

    CAS  PubMed  Google Scholar 

  77. Gould DS, Montenegro LM, Gaynor JW, et al. A comparison of on-site and off-site patent ductus arteriosus ligation in premature infants. Pediatrics. 2003;112:1298–301.

    PubMed  Google Scholar 

  78. Lago P, Meneghini L, Chiandetti L, Tormena F, Metrangolo S, Gamba P. Congenital diaphragmatic hernia: intensive care unit or operating room? Am J Perinatol. 2005;22:189–97.

    PubMed  Google Scholar 

  79. Frawley G, Bayley G, Chondros P. Laparotomy for necrotizing enterocolitis: intensive care nursery compared with operating theatre. J Paediatr Child Health. 1999;35:291–5.

    CAS  PubMed  Google Scholar 

  80. Allegaert K, Van de Velde M, Casteels I, Naulaers G, Vanhole C, Devlieger H. Cryotherapy for threshold retinopathy: perioperative management in a single center. Am J Perinatol. 2003;20:219–26.

    CAS  PubMed  Google Scholar 

  81. Zellers TM, Dixon K, Moake L, Wright J, Ramaciotti C. Bedside balloon atrial septostomy is safe, efficacious, and cost-effective compared with septostomy performed in the cardiac catheterization laboratory. Am J Cardiol. 2002;89:613–5.

    PubMed  Google Scholar 

  82. Karas CS, Baig MN, Elton SW. Ventriculosubgaleal shunts at Columbus Children's Hospital: Neurosurgical implant placement in the neonatal intensive care unit. J Neurosurg. 2007;107:220–3.

    PubMed  Google Scholar 

  83. Dos Santos AM, Guinsburg R, de Almeida MF, et al. Red Blood Cell Transfusions are Independently Associated with Intra-Hospital Mortality in Very Low Birth Weight Preterm Infants. J Pediatr. 2011;159(3):371–6.

    PubMed  Google Scholar 

  84. Barcelona SL, Thompson AA, Cote CJ. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part I: hematologic and physiologic differences from adults; metabolic and infectious risks. Paediatr Anaesth. 2005;15:716–26.

    PubMed  Google Scholar 

  85. Lee AC, Reduque LL, Luban NLC, Ness PM, Anton B, Heitmiller ES. Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion. Transfusion. 2013;54(1):244–54. doi:10.1111/trf12192.

    PubMed  Google Scholar 

  86. Sloan SR. Neonatal transfusion review. Paediatr Anaesth. 2011;21:25–30.

    PubMed  Google Scholar 

  87. Vraets A, Lin Y, Callum JL. Transfusion-associated hyperkalemia. Transfus Med Rev. 2011;25:184–96.

    PubMed  Google Scholar 

  88. Schindler E, Kowarld B, Suess H, et al. Catheterization of the radial or brachial artery in neonates and infants. Paediatr Anaesth. 2005;15:677–82.

    PubMed  Google Scholar 

  89. Beluffi G, Periotti G, Silco C, Fiori P, et al. Central venous catheters in premature babies: radiological evaluation, malpositioning and complications. Pediatr Radiol. 2012;42:1000–8.

    PubMed  Google Scholar 

  90. Jumani K, Advani S, Reich NG, et al. Risk factors for peripherally inserted central venous catheter complications in children. JAMA Pediatr. 2013;167:429–35.

    PubMed Central  PubMed  Google Scholar 

  91. Goutail-Flaud MF, Sfez M, Berg A, et al. Central venous catheter-related complications in newborns and infants: a 587-case survey. J Pediatr Surg. 1991;26:645–50.

    CAS  PubMed  Google Scholar 

  92. Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics. 1995;96:939–43.

    CAS  PubMed  Google Scholar 

  93. Njere I, Islam S, Parish D, et al. Outcome of peripherally inserted central venous catheters in surgical and medical neonates. J Pediatr Surg. 2011;46:946–50.

    PubMed  Google Scholar 

  94. Westergaard B, Classen V, Walther-Larsen S. Peripherally inserted central catheters in infants and children – indications, techniques complications, and clinical recommendations. Acta Anaesthesiol Scand. 2013;57:278–87.

    CAS  PubMed  Google Scholar 

  95. Chow LM, Friedman JN, Macarthur C, et al. Peripherally inserted central catheter (PICC) fracture and embolization in the pediatric population. J Pediatr. 2003;142:141–4.

    PubMed  Google Scholar 

  96. Hayes Jr D, Feola DJ, Murphy BS, Shook LA, Ballard HO. Pathogenesis of bronchopulmonary dysplasia. Respiration. 2010;79:425–36.

    PubMed  Google Scholar 

  97. Mani V, Morton NS. Overview of total intravenous anesthesia in children. Paediatr Anaesth. 2010;20:211–22.

    PubMed  Google Scholar 

  98. Tlucek PS, Corff KE, Bright BC, Bedwell SM, Sekar KC, Siatkowski RM. Effect of decreasing target oxygen saturation on retinopathy of prematurity. J AAPOS. 2010;14:406–11.

    PubMed  Google Scholar 

  99. Carlo WA, Finer NN, Walsh MC, et al. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010;362:1959–69.

    CAS  PubMed  Google Scholar 

  100. Stenson BJ, Tarnow-Mordi WO, Darlow BA, et al. Oxygen saturation and outcomes in preterm infants. N Engl J Med. 2013;368:2094–104.

    PubMed  Google Scholar 

  101. Askie LM, Henderson-Smart DJ, Ko H. Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birth weight infants. Cochrane Database Syst Rev 2009:CD001077.

    Google Scholar 

  102. Schmidt B, Whyte RK, Asztalos EV, et al. Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial. JAMA. 2013;309:2111–20.

    CAS  PubMed  Google Scholar 

  103. Bancalari E, Claure N. Oxygenation targets and outcomes in premature infants. JAMA. 2013;309:2161–2.

    CAS  PubMed  Google Scholar 

  104. Davis PG, Tan A, O'Donnell CP, Schulze A. Resuscitation of newborn infants with 100 % oxygen or air: a systematic review and meta-analysis. Lancet. 2004;364:1329–33.

    PubMed  Google Scholar 

  105. Rabi Y, Rabi D, Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation. 2007;72:353–63.

    PubMed  Google Scholar 

  106. Brown JVE, Moe-Byrne T, Harden M, et al. Lower versus higher oxygen concentration for delivery room stabilization of preterm neonates: systematic review. PLoS One. 2012;7(12):e52033.

    PubMed Central  CAS  PubMed  Google Scholar 

  107. Cernada M, Cubells E, Torres-Cuevas I, et al. Oxygen in the delivery room. Early Hum Dev. 2013;8951:S11–13.

    Google Scholar 

  108. Kattwinkel J, Perlman JM, Aziz K, et al. Part 15: neonatal resuscitation: 2010 American heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122:S909–19.

    PubMed  Google Scholar 

  109. Sola A. Oxygen in neonatal anesthesia: friend or foe? Curr Opin Anaesthesiol. 2008;21:332–9.

    PubMed  Google Scholar 

  110. Sola A, Rogido MR, Deulofeut R. Oxygen as a neonatal health hazard: call for detente in clinical practice. Acta Paediatr. 2007;96:801–12.

    PubMed  Google Scholar 

  111. van der Walt J. Oxygen - elixir of life or Trojan horse? Part 2: oxygen and neonatal anesthesia. Paediatr Anaesth. 2006;16:1205–12.

    PubMed  Google Scholar 

  112. Allnutt MF. Human factors in accidents. Br J Anaesth. 1987;59:856–64.

    CAS  PubMed  Google Scholar 

  113. Arbous MS, Meursing AE, van Kleef JW, et al. Impact of anesthesia management characteristics on severe morbidity and mortality. Anesthesiology. 2005;102:257–68. quiz 491-2.

    PubMed  Google Scholar 

  114. Campling EA, Devlin HB, Lunn JN. The report of the national confidential enquiry into perioperative deaths 1989. London, 1990. http://www.ncepod.org.uk/pdf/1989/Full%20Report%201989.pdf.

  115. Arul GS, Spicer RD. Where should paediatric surgery be performed? Arch Dis Child. 1998;79:65–70. discussion -2.

    PubMed Central  CAS  PubMed  Google Scholar 

  116. Hoffman GM. Outcomes of pediatric anesthesia. Semin Pediatr Surg. 2008;17:141–51.

    PubMed  Google Scholar 

  117. Irita K, Tsuzaki K, Sawa T, et al. The state of pediatric anesthesia in Japan: an analysis of the Japanese society of anesthesiologists survey of critical incidents in the operating room. Masui. 2007;56:93–102.

    PubMed  Google Scholar 

  118. Auroy Y, Ecoffey C, Messiah A, Rouvier B. Relationship between complications of pediatric anesthesia and volume of pediatric anesthetics. Anesth Analg. 1997;84:234–5.

    CAS  PubMed  Google Scholar 

  119. Keenan RL, Shapiro JH, Dawson K. Frequency of anesthetic cardiac arrests in infants: effect of pediatric anesthesiologists. J Clin Anesth. 1991;3:433–7.

    CAS  PubMed  Google Scholar 

  120. Mamie C, Habre W, Delhumeau C, Argiroffo CB, Morabia A. Incidence and risk factors of perioperative respiratory adverse events in children undergoing elective surgery. Paediatr Anaesth. 2004;14:218–24.

    PubMed  Google Scholar 

  121. Stoddart PA, Brennan L, Hatch DJ, Bingham R. Postal survey of paediatric practice and training among consultant anaesthetists in the UK. Br J Anaesth. 1994;73:559–63.

    CAS  PubMed  Google Scholar 

  122. Van Der Walt JH. Searching for the Holy Grail: measuring risk in paediatric anaesthesia. Paediatr Anaesth. 2001;11:637–41.

    Google Scholar 

  123. Anderson BJ. Developmental pharmacology; filling one knowledge gap in pediatric anesthesiology. Paediatric Anaesthesia. 2011;21:179–82.

    PubMed  Google Scholar 

  124. Johnson TN, Rostami-Hodjegan A. Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice. Paediatr Anaesth. 2011;21:291–301.

    PubMed  Google Scholar 

  125. Rigby-Jones AE, Sneyd JR. Propofol and children–what we know and what we do not know. Paediatr Anaesth. 2011;21:247–54.

    PubMed  Google Scholar 

  126. Anderson BJ, Holford NH. Tips and traps analyzing pediatric PK data. Paediatr Anaesth. 2011;21:222–37.

    PubMed  Google Scholar 

  127. Cooper L, Mossamann B. Medication errors in anesthesia: a review. Int Anesthesiol Clin. 2013;51:1–12.

    PubMed  Google Scholar 

  128. De Oliveira GS, Rahmani R, Fitzgerald PC, et al. The association between frequency of self-reported medical errors and anesthesia trainee supervision: a survey of United States Anesthesiology residents-in-training. Anesth Analg. 2013;116:892–7.

    PubMed  Google Scholar 

  129. Black S, Lerman J, Curia L, et al. Drug calculation errors in anesthesia residents and faculty. Abstract Anesthesiology. 2013;A4006.

    Google Scholar 

  130. Kaushal R, Bates DW, Landrigan C, et al. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001;285:2114–20.

    CAS  PubMed  Google Scholar 

  131. Wong ICK, Ghaleb MA, Franklin BD, Barber N. Incidence and nature of dosing errors in paediatric medications: a systematic review. Drug Saf. 2004;27:661–70.

    PubMed  Google Scholar 

  132. Muscolo S, Plevani L. Drug accountability and drug administration safety controls in the NICU. Early Hum Dev. 2012;88(2):S50–2.

    PubMed  Google Scholar 

  133. Kunac DL, Kennedy J, Austin N, Reith D. Incidence, preventability, and impact of Adverse Drug Events (ADEs) and potential ADEs in hospitalized children in New Zealand: a prospective observational cohort study. Paediatr Drugs. 2009;11:153–60.

    PubMed  Google Scholar 

  134. Ma H, Lovich MA, Peterfreund RA. Quantitative analysis of continuous intravenous infusions in pediatric anesthesia: safety implications of dead volume, flow rates, and fluid delivery. Paediatr Anaesth. 2011;21:78–86.

    PubMed  Google Scholar 

  135. Zenk KE. Intravenous drug delivery in infants with limited i.v. access and fluid restriction. Am J Hosp Pharm. 1987;44:2542–5.

    CAS  PubMed  Google Scholar 

  136. Humma KG. Covert administration of benzyl alcohol to neonates. Pediatrics. 1982;70:509–10.

    CAS  PubMed  Google Scholar 

  137. Merry AF, Anderson BJ. Medication errors – new approaches to prevention. Paediatric Aanesthesia. 2011;21(7):743–53.

    Google Scholar 

  138. Orser BA, Hyland S, U D, Sheppard I. Improving drug safety for patients undergoing anesthesia and surgery. Can J Anaesth. 2013;60:12.

    Google Scholar 

  139. Paterson N, Waterhouse P. Review article: risk in pediatric anesthesia. Pediatr Anesth. 2011;21(8):848–857.

    Google Scholar 

  140. von Ungern-Sternberg BS, Boda K, Chambers NA, et al. Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study. Lancet. 2010;376:773–83.

    Google Scholar 

  141. WAKE UP SAFE – The pediatric anesthesia quality improvement initiative. http://wakeupsafe.org/index.iphtml. Accessed 25 May 2011.

  142. Davis PJ. When assessing what we know we don't know is not enough: another perspective on pediatric outcomes. Anesth Analg. 2007;105:301–3.

    PubMed  Google Scholar 

  143. American Academy of Pediatrics. Neonatal anesthesia. Pediatrics. 1987;80:446.

    Google Scholar 

  144. Anand KJ, Brown MJ, Causon RC, Christofides ND, Bloom SR, Aynsley-Green A. Can the human neonate mount an endocrine and metabolic response to surgery? J Pediatr Surg. 1985;20:41–8.

    CAS  PubMed  Google Scholar 

  145. Fredriksson A, Archer T, Alm H, Gordh T, Eriksson P. Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration. Behav Brain Res. 2004;153:367–76.

    CAS  PubMed  Google Scholar 

  146. Ikonomidou C, Bittigau P, Koch C, et al. Neurotransmitters and apoptosis in the developing brain. Biochem Pharmacol. 2001;62:401–5.

    CAS  PubMed  Google Scholar 

  147. Ikonomidou C, Bosch F, Miksa M, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science. 1999;283:70–4.

    CAS  PubMed  Google Scholar 

  148. Olney JW, Wozniak DF, Jevtovic-Todorovic V, Farber NB, Bittigau P, Ikonomidou C. Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol. 2002;12:488–98.

    CAS  PubMed  Google Scholar 

  149. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci. 2003;23:876–82.

    CAS  PubMed  Google Scholar 

  150. Slikker Jr W, Zou X, Hotchkiss CE, et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci. 2007;98:145–58.

    CAS  PubMed  Google Scholar 

  151. Mellon RD, Simone AF, Rappaport BA. Use of anesthetic agents in neonates and young children. Anesth Analg. 2007;104:509–20.

    CAS  PubMed  Google Scholar 

  152. Summary Minutes for the March 10, 2011 Meeting of the Anesthetic and Life Support Drugs Advisory Committee. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndLifeSupportDrugsAdvisoryCommittee/UCM251282.pdf. Accessed 5 May 2011.

  153. Transcript for the March 10, 2011 Meeting of the Anesthetic and Life Support Drugs Advisory Committee. 2011. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndLifeSupportDrugsAdvisoryCommittee/UCM251283.pdf. Accessed 5 May 2011

  154. Rappaport B, Mellon D, Simone A, Woodcock J. Defining safe use of anesthesia in children. N Engl J Med. 2011;364:1387–90.

    CAS  PubMed  Google Scholar 

  155. Davidson AJ, McCann ME, Morton NS, Myles PS. Anesthesia and outcome after neonatal surgery: the role for randomized trials. Anesthesiology. 2008;109:941–4.

    PubMed  Google Scholar 

  156. Anand KJ. Anesthetic neurotoxicity in newborns: should we change clinical practice? Anesthesiology. 2007;107:2–4.

    PubMed  Google Scholar 

  157. Loepke AW, McGowan Jr FX, Soriano SG. CON: The toxic effects of anesthetics in the developing brain: the clinical perspective. Anesth Analg. 2008;106:1664–9.

    PubMed  Google Scholar 

  158. McGowan Jr FX, Davis PJ. Anesthetic-related neurotoxicity in the developing infant: of mice, rats, monkeys and, possibly, humans. Anesth Analg. 2008;106:1599–602.

    PubMed  Google Scholar 

  159. Berde C, Cairns B. Developmental pharmacology across species: promise and problems. Anesth Analg. 2000;91:1–5.

    CAS  PubMed  Google Scholar 

  160. Jevtovic-Todorovic V, Olney JW. PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008;106:1659–63.

    PubMed  Google Scholar 

  161. Ikonomidou C, Bittigau P, Ishimaru MJ, et al. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science. 2000;287:1056–60.

    CAS  PubMed  Google Scholar 

  162. Zou X, Patterson TA, Divine RL, et al. Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int J Dev Neurosci. 2009;27:727–31.

    CAS  PubMed  Google Scholar 

  163. Anand KJ. Effects of perinatal pain and stress. Prog Brain Res. 2000;122:117–29.

    CAS  PubMed  Google Scholar 

  164. Loepke AW, Soriano SG. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg. 2008;106:1681–707.

    PubMed  Google Scholar 

  165. Anand KJ, Garg S, Rovnaghi CR, Narsinghani U, Bhutta AT, Hall RW. Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res. 2007;62:283–90.

    CAS  PubMed  Google Scholar 

  166. Rovnaghi CR, Garg S, Hall RW, Bhutta AT, Anand KJ. Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long-term effects. Behav Brain Funct. 2008;4:35.

    PubMed Central  PubMed  Google Scholar 

  167. Liu J, Baek C, Han X, Athiraman U, Soriano SG. Differential regulation of survival kinases by noxious stimulation during ketamine-induced developmental neuroapoptosis. In: Pediatric anesthesiology. San Diego; 2011.

    Google Scholar 

  168. Itoh T, Imano M, Nishida S, et al. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury. J Neural Transm. 2011;118(9):1263–72.

    Google Scholar 

  169. Shih J, May LDV, Gonzalez HE, et al. Delayed environmental enrichment reverse sevoflurane-induced memory impairment in rats. Anesthesiology. 2012;116:586–602.

    PubMed Central  CAS  PubMed  Google Scholar 

  170. Turner CP, Gutierrez S, Liu C, et al. Strategies to defeat ketamine-induced neonatal brain injury. Neuroscience. 2012;210:384–92.

    PubMed Central  CAS  PubMed  Google Scholar 

  171. Oz S, Ivashko-Pachima Y, Gozes I. The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS One. 2012;7(12):e51458.

    PubMed Central  CAS  PubMed  Google Scholar 

  172. Gozes I. Microtubules (tau) as an emerging therapeutic target: NAP (Davunetide). Curr Pharm Des. 2011;17:3413–7.

    CAS  PubMed  Google Scholar 

  173. Chauvier D, Renolleau S, Holifanjaniaina S, et al. Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis. 2011;2:e203.

    PubMed Central  CAS  PubMed  Google Scholar 

  174. Pellegrini L, Bennis Y, Velly L, et al. Erythropoietin protects newborn rat against sevoflurane-induced neurotoxicity. Paediatr Anaesth. 2014;24:749–59.

    PubMed  Google Scholar 

  175. DiMaggio C, Sun LS, Kakavouli A, Byrne MW, Li G. A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. J Neurosurg Anesthesiol. 2009;21:286–91.

    PubMed Central  PubMed  Google Scholar 

  176. Wilder RT, Flick RP, Sprung J, et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology. 2009;110:796–804.

    PubMed Central  PubMed  Google Scholar 

  177. Kalkman CJ, Peelen L, Moons KG, et al. Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology. 2009;110:805–12.

    PubMed  Google Scholar 

  178. Kalkman CJ, Peelen L. Victorian water pumps and anesthetic neurotoxicity. J Neurosurg Anesthesiol. 2009;21:283–5.

    PubMed  Google Scholar 

  179. DiMaggio C, Sun L, Li G. Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg. 2011;113:1143–51.

    PubMed Central  PubMed  Google Scholar 

  180. Bartels M, Althoff RR, Boomsma DI. Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet. 2009;12:246–53.

    PubMed  Google Scholar 

  181. O'Brien G. Adult outcome of childhood learning disability. Dev Med Child Neurol. 2001;43:634–8.

    PubMed  Google Scholar 

  182. Sprung J, Flick RP, Wilder RT, et al. Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology. 2009;111:302–10.

    PubMed Central  PubMed  Google Scholar 

  183. Hansen TG, Pedersen JK, Henneberg SW, et al. Academic performance in adolescence after inguinal hernia repair in infancy: A nationwide cohort study. Anesthesiology. 2011;114(5):1076–85.

    PubMed  Google Scholar 

  184. A multi-site randomised controlled trial comparing regional and general anaesthesia for effects on neurodevelopmental outcome and apnoea in infants (GAS). http://www.clinicaltrials.gov 2006:NCT00756600.

  185. Sun LS, Li G, Dimaggio C, et al. Anesthesia and neurodevelopment in children: time for an answer? Anesthesiology. 2008;109:757–61.

    PubMed  Google Scholar 

  186. Durieux M, Davis PJ. The Safety of Key Inhaled and Intravenous Drugs in Pediatrics (SAFEKIDS): an update. Anesth Analg. 2010;110:1265–7.

    PubMed  Google Scholar 

  187. SAFEKIDS Announces Name Change. 2010. http://www.smarttots.org/news.html. Accessed 22 May 3011.

  188. FDA Launches SAFEKIDS Initiative with Academic and Clinical Partners: Public-Private Partnership will assess safety of anesthetics and sedatives in young children U.S. Food and Drug Administration, 2009. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149543.htm. Accessed 25 May 2011.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pete G. Kovatsis MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kovatsis, P.G., Kleinman, M. (2015). Anesthetic Complications in the Neonate. In: Lerman, J. (eds) Neonatal Anesthesia. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6041-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-6041-2_16

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-6040-5

  • Online ISBN: 978-1-4419-6041-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics