Hereditary Diffuse Gastric Cancer

Part of the Cancer Treatment and Research book series (CTAR, volume 155)


Gastric cancer is one of the world’s leading causes of cancer mortality. A small percentage of cases can be attributed to heritable mutations in highly penetrant cancer susceptibility genes. In this chapter we will focus on the genetic cause of hereditary diffuse gastric cancer (HDGC). Until 10 years ago, individuals from these families lived with the uncertainty of developing lethal gastric cancer. Today, HDGC families can be identified, tested for causative mutations in CDH1, and for those families where a pathogenic mutation can be identified, prophylactic total gastrectomy can be implemented in asymptomatic mutation carriers who elect to virtually eliminate their risk of developing this lethal disease.


Gastric Cancer Pylorus Infection Lynch Syndrome Signet Ring Cell Gastric Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory Medicine and Department of Medical GeneticsUniversity of British Columbia, British Columbia Cancer AgencyVancouverCanada
  2. 2.Department of Pathology and Laboratory Medicine, Vancouver General HospitalUniversity of British Columbia, British Columbia Cancer AgencyVancouverCanada

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