Abstract
This chapter provides an overview of the pathogenesis of atherosclerosis, and integrates the latest clinical guidelines and trials into a concise and practical guide to cardiovascular risk reduction and the management of dyslipidemia. These measures form the basis for a management strategy aimed at halting the progression of atherosclerosis, stabilizing rupture-prone plaques, preventing arterial thrombosis, and improving cardiovascular prognosis.
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References
AHA (2009) Heart Disease and Stroke Statistics – 2009 Update. American Heart Association, Dallas, TX
Baigent C, Keech A, Kearney P, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R (2005) Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 366:1267–1278
Ford E, Li C, Pearson W, Zhao G, Mokdad A (2010) Trends in hypercholesterolemia, treatment and control among United States adults. Int J Cardiol 140:226–235
Ross R (1999) Atherosclerosis – an inflammatory disease. N Engl J Med 340:115–126
Libby P, Theroux P (2005) Pathophysiology of coronary artery disease. Circulation 111:3481–3488
Lavi S, McConnell J, Rihal C, Prasad A, Mathew V, Lerman L, Lerman A (2007) Local Âproduction of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans. Circulation 115:2715–2721
Ambrose J, Tannenbaum M, Alexopoulos D, Hjemdahl-Monsen C, Leavy J, Weiss M, Borrico S, Gorlin R, Fuster V (1988) Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 12:56–62
Nissen S, Nicholls S, Sipahi I, Libby P, Raichlen J, Ballantyne C, Davignon J, Erbel R, Fruchart J, Tardif J, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu E (2006) Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 295:1556–1565
Nissen S, Tuzcu E, Schoenhagen P, Brown B, Ganz P, Vogel R, Crowe T, Howard G, Cooper C, Brodie B, Grines C, DeMaria A (2004) Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA 291:1071–1080
Libby P, Sasiela W (2006) Plaque stabilization: Can we turn theory into evidence? Am J Cardiol 98:26P–33P
Ostad M, Eggeling S, Tschentscher P, Schwedhelm E, Böger R, Wenzel P, Meinertz T, Munzel T, Warnholtz A (2009) Flow-mediated dilation in patients with coronary artery Âdisease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: results of the CEZAR study. Atherosclerosis 205:227–232
Kuklina E, Yoon P, Keenan N (2009) Trends in high levels of low-density lipoprotein cholesterol in the United States, 1999–2006. JAMA 302:2104–2110
Castelli W (1984) Epidemiology of coronary heart disease: the Framingham study. Am J Med 76:4–12
Waters D, Brotons C, Chiang C, Ferrières J, Foody J, Jukema J, Santos R, Verdejo J, Messig M, McPherson R, Seung K, Tarasenko L (2009) Lipid Treatment Assessment Project 2: a Âmultinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Circulation 120:28–34
Corti M, Guralnik J, Salive M, Harris T, Ferrucci L, Glynn R, Havlik R (1997) Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann Intern Med 126:753–760
National Cholesterol Education Program (2002) Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421
Wilson P, Anderson K, Castelli W (1991) Twelve-year incidence of coronary heart disease in middle-aged adults during the era of hypertensive therapy: the Framingham Offspring Study. Am J Med 90:11–16
Gordon D, Probstfield J, Garrison R, Neaton J, Castelli W, Knoke J, Jacobs DJ, Bangdiwala S, Tyroler H (1989) High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 79:8–15
Brugts J, Yetgin T, Hoeks S, Gotto A, Shepherd J, Westendorp R, de Craen A, Knopp R, Nakamura H, Ridker P, van Domburg R, Deckers J (2009) The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. BMJ 338:b2376
Ballantyne C, Raichlen J, Nicholls S, Erbel R, Tardif J, Brener S, Cain V, Nissen S (2008) Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden. Circulation 117:2458–2466
Smilde T, van Wissen S, Wollersheim H, Trip M, Kastelein J, Stalenhoef A (2001) Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 357:577–581
Taylor A, Kent S, Flaherty P, Coyle L, Markwood T, Vernalis M (2002) ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 106:2055–2060
Crouse JR, Raichlen J, Riley W, Evans G, Palmer M, O’Leary D, Grobbee D, Bots M (2007) Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR trial. JAMA 297:1344–1353
Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7–22
Ridker P, Danielson E, Fonseca F, Genest J, Gotto AM Jr., Kastelein J, Koenig W, Libby P, Lorenzatti A, MacFadyen J, Nordestgaard B, Shepherd J, Willerson J, Glynn R (2008) Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359:2195–2207
Cannon C, Braunwald E, McCabe C, Rader D, Rouleau J, Belder R, Joyal S, Hill K, Pfeffer M, Skene A (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350:495–504
LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, Gotto AM, Greten H, Kastelein JJ, Shepherd J, Wenger NK (2005) Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 352:1425–1435
Pedersen TR, Faergeman O, Kastelein JJ, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Bendiksen FS, Lindahl C, Szarek M, Tsai J (2005) High-dose atorvastatin vs usual-dose Âsimvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. JAMA 294:2437–2445
Grundy SM, Cleeman JI, Bairey Merz CN, Brewer HB Jr., Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr., Stone NJ (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110:227–239
Smith SJ, Allen J, Blair S, Bonow R, Brass L, Fonarow G, Grundy S, Hiratzka L, Jones D, Krumholz H, Mosca L, Pasternak R, Pearson T, Pfeffer M, Taubert K (2006) AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic Âvascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circulation 113:2363–2372
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Saunders, J.T., Ballantyne, C.M. (2011). Rust and Rupture: Atherosclerosis. In: Davies, M., Lumsden, A., Kline, W., Kakadiaris, I. (eds) Pumps and Pipes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6012-2_8
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DOI: https://doi.org/10.1007/978-1-4419-6012-2_8
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