Précis
Malignant transformation is not an entirely “cell-centric” event. It also involves disrupted homeostasis between a perturbed cell and its disturbed niche.
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References
Schofield R (1978) The relationship between the spleen colony-forming cell and the hematopoietic stem cell. Blood Cells 4:7–25
Kai T, Spradling A (2003) An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc Natl Acad Sci USA 100:4633–4638
Stevens LC (1964) Experimental production of testicular teratomas in mice. Proc Natl Acad Sci USA 52:654–661
Mintz B, Illmensee K (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72:3585–3589
Dolberg DS, Bissell MJ (1984) Inability of Rous sarcoma virus to cause sarcomas in avian embryo. Nature 309:552–556
Gershenson M, Graves K, Carson SD, Wells RS, Pierce GB (1986) Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci USA 83:7307–7310
Topczewska JM, Postovit L-M, Margaryan NV et al (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925–932
Postovit LM, Seftor EA, Seftor REB, Hendrix MJC (2006) A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24:501–505
Fialkow PJ, Thomas ED, Bryant JI, Neiman PE (1971) Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1:251–255
Flynn CM, Kauffman DS (2007) Donor cell leukemia: insights into cancer stem cells and the stem cell niche. Blood 109:2688–2692
Hertenstein B, Hambach L, Bacigalupo A et al; Complications Subcommittee of the Chronic Leukaemia Working Party of the EBMT (2005) Development of leukemia in donor cells after allogeneic stem cells transplantation – a survey of the European Group for Blood and Marrow Transplantation (EBMT). Hematologica 90:969–975
Stoler DL, Chen N, Basik M et al (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 96:15121–15126
Barcellos-Hoff MH, Ravani SA (2000) Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 60:1254–1260
Bhowmick NA, Chytil A, Plieth D et al (2004) TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303:848–851
Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS (1996) Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274:2057–2059
Grum-Schwensen B, Klingelhofer J, Berg CH et al (2005) Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 65:3772–3780
Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335–348
Littlepage LE, Egeblad M, Werb Z (2005) Coevolution of cancer and stromal cellular responses. Cancer Cell 7:499–500
Kaplan RN, Riba RD, Zacharoulis S et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820–827
McAllister SS, Gifford AM, Greiner AL et al (2008) Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133:994–1005
Tu S-M, Lin S-H (2008) Current trials using bone-targeting agents in prostate cancer [review]. Cancer J 14(1):35–39, Erratum in Cancer J 2008;14(3):199
Covello KL, Kehler J, Yu H et al (2006) HIF-2a regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 20:557–570
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Tu, SM. (2010). Cancer Niche. In: Origin of Cancers. Cancer Treatment and Research, vol 154. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5968-3_8
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DOI: https://doi.org/10.1007/978-1-4419-5968-3_8
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