Skip to main content

Cancer Niche

  • Chapter
  • First Online:
Origin of Cancers

Part of the book series: Cancer Treatment and Research ((CTAR,volume 154))

  • 942 Accesses

Précis

Malignant transformation is not an entirely “cell-centric” event. It also involves disrupted homeostasis between a perturbed cell and its disturbed niche.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Schofield R (1978) The relationship between the spleen colony-forming cell and the hematopoietic stem cell. Blood Cells 4:7–25

    CAS  PubMed  Google Scholar 

  2. Kai T, Spradling A (2003) An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc Natl Acad Sci USA 100:4633–4638

    Article  CAS  PubMed  Google Scholar 

  3. Stevens LC (1964) Experimental production of testicular teratomas in mice. Proc Natl Acad Sci USA 52:654–661

    Article  CAS  PubMed  Google Scholar 

  4. Mintz B, Illmensee K (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72:3585–3589

    Article  PubMed  Google Scholar 

  5. Dolberg DS, Bissell MJ (1984) Inability of Rous sarcoma virus to cause sarcomas in avian embryo. Nature 309:552–556

    Article  CAS  PubMed  Google Scholar 

  6. Gershenson M, Graves K, Carson SD, Wells RS, Pierce GB (1986) Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci USA 83:7307–7310

    Article  Google Scholar 

  7. Topczewska JM, Postovit L-M, Margaryan NV et al (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925–932

    Article  CAS  PubMed  Google Scholar 

  8. Postovit LM, Seftor EA, Seftor REB, Hendrix MJC (2006) A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24:501–505

    Article  CAS  PubMed  Google Scholar 

  9. Fialkow PJ, Thomas ED, Bryant JI, Neiman PE (1971) Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1:251–255

    Article  CAS  PubMed  Google Scholar 

  10. Flynn CM, Kauffman DS (2007) Donor cell leukemia: insights into cancer stem cells and the stem cell niche. Blood 109:2688–2692

    CAS  PubMed  Google Scholar 

  11. Hertenstein B, Hambach L, Bacigalupo A et al; Complications Subcommittee of the Chronic Leukaemia Working Party of the EBMT (2005) Development of leukemia in donor cells after allogeneic stem cells transplantation – a survey of the European Group for Blood and Marrow Transplantation (EBMT). Hematologica 90:969–975

    Google Scholar 

  12. Stoler DL, Chen N, Basik M et al (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 96:15121–15126

    Article  CAS  PubMed  Google Scholar 

  13. Barcellos-Hoff MH, Ravani SA (2000) Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 60:1254–1260

    CAS  PubMed  Google Scholar 

  14. Bhowmick NA, Chytil A, Plieth D et al (2004) TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303:848–851

    Article  CAS  PubMed  Google Scholar 

  15. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS (1996) Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274:2057–2059

    Article  CAS  PubMed  Google Scholar 

  16. Grum-Schwensen B, Klingelhofer J, Berg CH et al (2005) Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 65:3772–3780

    Article  CAS  PubMed  Google Scholar 

  17. Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335–348

    Article  CAS  PubMed  Google Scholar 

  18. Littlepage LE, Egeblad M, Werb Z (2005) Coevolution of cancer and stromal cellular responses. Cancer Cell 7:499–500

    Article  CAS  PubMed  Google Scholar 

  19. Kaplan RN, Riba RD, Zacharoulis S et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820–827

    Article  CAS  PubMed  Google Scholar 

  20. McAllister SS, Gifford AM, Greiner AL et al (2008) Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133:994–1005

    Article  CAS  PubMed  Google Scholar 

  21. Tu S-M, Lin S-H (2008) Current trials using bone-targeting agents in prostate cancer [review]. Cancer J 14(1):35–39, Erratum in Cancer J 2008;14(3):199

    Article  CAS  PubMed  Google Scholar 

  22. Covello KL, Kehler J, Yu H et al (2006) HIF-2a regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 20:557–570

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shi-Ming Tu .

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Tu, SM. (2010). Cancer Niche. In: Origin of Cancers. Cancer Treatment and Research, vol 154. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5968-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-5968-3_8

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-5967-6

  • Online ISBN: 978-1-4419-5968-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics