Skip to main content
SpringerLink
Log in

Stem Cells and Cancer

  • Chapter
  • First Online:
Origin of Cancers

Part of the book series: Cancer Treatment and Research ((CTAR,volume 154))

  • 985 Accesses

Précis

In principle, any cell with stem-cell properties is poised to become malignant given the right conditions and circumstances. The stem-cell characteristic is what gives cancer its free rein.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. McCallum H, Tompkins DM, Jones M et al (2007) Distribution and impacts of Tasmanian devil facial tumor disease. Ecohealth 4:318–325

    Article  Google Scholar 

  2. Pearse A-M, Swift K (2006) Allograft theory: transmission of devil facial-tumour disease. Nature 439:549

    Article  CAS  PubMed  Google Scholar 

  3. Siddle HV, Kreiss A, Eldridge MD et al (2007) Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. Proc Natl Acad Sci USA 104:16221–16226

    Article  CAS  PubMed  Google Scholar 

  4. Loh R, Bergfeld J, Hayes D et al (2006) The pathology of devil facial tumor disease (DFTD) in Tasmanian devils (Sarcophilus harrisii). Vet Pathol 43:890–895

    Article  CAS  PubMed  Google Scholar 

  5. Jones ME, Paetkau D, Geffen E, Moritz C (2004) Genetic diversity and population structure of Tasmanian devils, the largest marsupial carnivore. Mol Ecol 13:2197–2209

    Article  CAS  PubMed  Google Scholar 

  6. Barsky SH, Ye Y, Xiao Y, Yearley K (2008) Insights into the stem cell origin of human cancers by studying a registry of bone marrow and other organ transplant recipients who later developed solid tumors [abstr]. Am Soc Clin Oncol 580 [Abstract 11010]

    Google Scholar 

  7. Woods NB, Bottero V, Schmidt M, von Kalle C, Verma IM (2006) Gene therapy: therapeutic gene causing lymphoma. Nature 440:1123

    Article  CAS  PubMed  Google Scholar 

  8. Hacein-Bey-Abina S, von Kalle C, Schmidt M et al (2003) A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348:255–256

    Article  PubMed  Google Scholar 

  9. Marshall E (2003) Second child in French trial is found to have leukemia. Science 299:320

    Article  CAS  PubMed  Google Scholar 

  10. Boyd CN, Ramberg RC, Thomas ED (1982) The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation. Leuk Res 6:833–837

    Article  CAS  PubMed  Google Scholar 

  11. Cooley LD, Sears DA, Udden MM, Harrison WR, Baker KR (2000) Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature. Am J Hematol 63:46–53

    Article  CAS  PubMed  Google Scholar 

  12. Hambach L, Eder M, Dammann E et al (2001) Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant 28:705–707

    Article  CAS  PubMed  Google Scholar 

  13. Beachy PA, Karhadkar SS, Berman DM (2004) Tissue repair and stem cell renewal in carcinogenesis. Nature 432:324–331

    Article  CAS  PubMed  Google Scholar 

  14. Warner KE, Mackay JL (2008) Smoking cessation treatment in a public-health context [comment]. Lancet 371:1976–1978

    Article  PubMed  Google Scholar 

  15. Houghton J, Stoicov C, Nomura S et al (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571

    Article  CAS  PubMed  Google Scholar 

  16. Cosme-Blanco W, Shen MF, Lazar AJ et al (2007) Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 8:497–503

    Article  CAS  PubMed  Google Scholar 

  17. Morrison S (2006) Stem cell self-renewal, cancer cell proliferation, and aging. In: 59th annual symposium on cancer research: stem cells in cancer and regenerative medicine, Houston, TX, October 27–29, p 37

    Google Scholar 

  18. Janzen V, Forkert R, Fleming H et al (2006) Stem cell aging modified by the cyclin dependent kinase inhibitor, p16INK4a. Nature 443:421–426

    CAS  PubMed  Google Scholar 

  19. Krishnamurthy J, Ransey M, Ligon K, Torrice C, Koh A, Bonner-Weir S, Sharpless NE (2006) p16INK4a induces age-dependent decline in islet regenerative potential [letter]. Nature 443:453–457

    Article  CAS  PubMed  Google Scholar 

  20. Molofsky AV, Slutsky SG, Joseph NM et al (2006) Increasing p16Ink4a expression reduces forebrain progenitor function and neurogenesis during aging. Nature 443:448–452

    Article  CAS  PubMed  Google Scholar 

  21. Ornish D, Lin J, Daubenmier J et al (2008) Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol 9:1048–1057, Erratum in Lancet Oncol 2008;9(12):1124

    Article  CAS  PubMed  Google Scholar 

  22. Boccaccio C, Comoglio PM (2006) Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 6:637–645

    Article  CAS  PubMed  Google Scholar 

  23. Ju Z, Rudolph KL (2006) Telomeres and telomerase in cancer stem cells. Eur J Cancer 42:1197–1203

    Article  CAS  PubMed  Google Scholar 

  24. Flores I, Cayuela ML, Blasco MA (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309:1253–1256

    Article  CAS  PubMed  Google Scholar 

  25. Fukasawa K, Wiener F, Vande Woude GF, Mai S (1997) Genomic instability and apoptosis are frequent in p53 deficient young mice. Oncogene 15:1295–1302

    Article  CAS  PubMed  Google Scholar 

  26. Comai L (2000) Genetic and epigenetic interactions in allopolyploid plants. Plant Mol Biol 43:387–399

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Shi-Ming Tu

Authors
  1. Shi-Ming Tu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shi-Ming Tu .

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Tu, SM. (2010). Stem Cells and Cancer. In: Origin of Cancers. Cancer Treatment and Research, vol 154. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5968-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-5968-3_6

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-5967-6

  • Online ISBN: 978-1-4419-5968-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation