Medullary Thyroid Carcinoma

Part of the Essentials in Cytopathology book series (EICP, volume 8)


Unlike most other carcinomas arising from the follicular cell of the thyroid, medullary thyroid carcinoma (MTC) is a malignancy with neuroendocrine features, derived from the parafollicular C cell, which is of ectodermal neural crest origin. In most studies, MTC represents 3–12% of thyroid cancers, the majority of which are sporadic. However, in approximately 25–30% of cases, MTC is inherited, and is associated with one of three familial syndromes: multiple endocrine neoplasia (MEN) syndrome type 2A, MEN type 2B, and familial MTC (Table 10.1). In contrast to sporadic cases of MTC, germline RET proto-oncogene mutations are often detected in inherited cases, which may facilitate early diagnosis.


Medullary Thyroid Carcinoma Small Cell Carcinoma Modify Radical Neck Dissection Spindle Cell Carcinoma Familial Medullary Thyroid Carcinoma 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of Pathology Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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