Abstract
Acute renal failure (ARF) is a common problem in the ICU. Even modest degrees of ARF not resulting in dialysis treatment increase the risk of death approximately fivefold.1 The mortality of patients who require dialysis has remained in excess of 50% despite improvements in renal replacement therapy and aggressive supportive care. It is therefore essential that all efforts be made to avoid this complication, i.e., aggressive (early) fluid resuscitation and avoidance of potentially nephrotoxic drugs (especially aminoglycosides and contrast media). The therapeutic intervention of choice in patients with oliguria is fluid resuscitation and not furosemide/Lasix™ (see Chapter 8).
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References
Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality. A cohort analysis. JAMA. 1996;275:1489–1494.
Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Low dose dopamine in patients with early renal dysfunction: a placebo-controlled trial. Lancet. 2000;356:2139–2143.
Brown CB, Ogg CS, Cameron JS. High dose furosemide in acute renal failure: a controlled trial. Clin Nephrol. 1981;15:90–96.
Lucas CE, Zito JG, Carter KM, et al. Questionable value of furosemide in preventing renal failure. Surgery. 1977;82:341–320.
Kleinknecht D, Ganeval D, Gonzalez-Duque LA, et al. Furosemide in acute oliguric renal failure. A controlled trial. Nephron. 1976;17:51–58.
Mehta RL, Pascual MT, Soroko S, et al. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA. 2002;288:2547–2553.
Ho KM, Sheridan DJ. Meta-analysis of furosemide to prevent or treat acute renal failure. BMJ. 2006;333:420.
Morcos SK, Thomsen HS, Webb JA. Contrast-media-induced nephrotoxicity: a consensus report. Contrast Media Safety Committee, European Society of Urogenital Radiology (ESUR). Eur Radiol. 1999;9:1602–1613.
Thomsen HS, Morcos SK. Contrast-medium-induced nephropathy: is there a new consensus? A review of published guidelines. Eur Radiol. 2006;16:1835–1840.
Barrett BJ, Carlisle EJ. Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media. Radiology. 1993;188:171–178.
Kelly AM, Dwamena B, Cronin P, et al. Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann Intern Med. 2008;148:284–294.
Marenzi G, Assanelli E, Marana I, et al. N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med. 2006;354:2773–2782.
Tepel M, van der Giet M, Schwarzfeld C, et al. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med. 2000;343:180–184.
Solomon R, Werner C, Mann D, et al. Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents. N Engl J Med. 1994;331:1416–1420.
Weisbord SD, Palevsky PM. Acute renal failure in the intensive care unit. Semin Respir Crit Care Med. 2006;27:262–273.
Pannu N, Klarenbach S, Wiebe N, et al. Renal replacement therapy in patients with acute renal failure: a systematic review. JAMA. 2008;299:793–805.
Mehta RL, McDonald B, Gabbai FB, et al. A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. Kidney Int. 2001;60:1154–1163.
Augustine JJ, Sandy D, Seifert TH, et al. A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. Am J Kidney Dis. 2004;44:1000–1007.
Tonelli M, Manns B, Feller-Kopman D. Acute renal failure in the intensive care unit: a systematic review of the impact of dialytic modality on mortality and renal recovery. Am J Kidney Dis. 2002;40:875–885.
Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet. 2000;356:26–30.
Palevsky PM, Zhang JH, O'Connor TZ, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7–20.
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Marik, P.E. (2010). Acute Renal Failure. In: Handbook of Evidence-Based Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5923-2_44
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DOI: https://doi.org/10.1007/978-1-4419-5923-2_44
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